中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (13): 2060-2069.doi: 10.3969/j.issn.2095-4344.3505
• 干细胞综述 stem cell review • 上一篇 下一篇
樊飞燕,张运克
收稿日期:
2020-03-28
修回日期:
2020-04-09
接受日期:
2020-05-30
出版日期:
2021-05-08
发布日期:
2020-12-28
通讯作者:
张运克,男,1966年生,河南省平顶山市人,汉族,2002年黑龙江中医药大学毕业,博士,2007年从中国中医科学院博士后流动站出站,教授,主任医师,博士生导师,博士后合作导师,主要从事中医药防治神经系统疾病的研究。
作者简介:
樊飞燕,女,1996年生,河南省许昌市人,汉族,河南中医药大学在读硕士,主要从事中医药防治神经内科疾病的研究。
基金资助:
Fan Feiyan, Zhang Yunke
Received:
2020-03-28
Revised:
2020-04-09
Accepted:
2020-05-30
Online:
2021-05-08
Published:
2020-12-28
Contact:
Zhang Yunke, MD, Professor, Chief physician, Doctoral supervisor, Post-doctoral cooperative supervisor, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
About author:
Fan Feiyan, Master candidate, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
Supported by:
摘要:
文题释义:
骨髓间充质干细胞:是存在于骨髓中的具有高度自我更新能力和多向分化潜能的干细胞群体,具有支持造血、多向分化潜能以及在细胞和基因工程中具有潜在应用前景等特点。
血管新生:是指在原有血管基础上通过血管内皮细胞增殖、芽生、游走、血管分裂和分支而形成新的毛细血管网,使其功能与局部需要相适应的生物学过程,主要过程包括:激活期血管基底膜降解;血管内皮细胞的激活、增殖、迁移;重建形成新的血管和血管网。
背景:骨髓间充质干细胞具有促进血管新生的作用,治疗缺血性脑卒中效果良好,益气活血类中药在促进血管新生方面亦存在显著疗效。
目的:综述益气活血类中药联合骨髓间充质干细胞促进缺血性脑卒中血管新生的机制,以期为缺血性脑卒中的研究及治疗提供参考。
方法:以“bone marrow mesenchymal stem cells,angiogenesis,ischemic stroke,traditional chinese medicine” 为英文关键词,以“骨髓间充质干细胞,血管新生,缺血性脑卒中,中药”为中文关键词,检索 2009 至 2020 年期间收录在 PubMed、中国知网、万方数据库中的文献,纳入血管新生相关机制及中药联合骨髓间充质干细胞促进血管新生相关的文献,排除重复与相关性弱的文献,对145篇文献进行总结分析。
结果与结论:①梳理了骨髓间充质干细胞、血管新生的定义及血管新生的机制;②总结了益气活血类中药联合骨髓间充质干细胞促进血管新生的相关因子及信号通路,如血管内皮生长因子、脑源性神经营养因子、碱性成纤维细胞生长因子、缺氧诱导因子1α、血管生成素、整合素αvβ3、基质金属蛋白酶9及Wnt信号通路、Notch信号通路、PI3K/Akt信号通路和SDF-1/CXCR4信号轴;③总结发现益气活血类中药与骨髓间充质干细胞联合应用能增强血管新生作用,提升缺血性脑卒中的治疗效果。
https://orcid.org/0000-0003-1500-1535(张运克)
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
中图分类号:
樊飞燕, 张运克. 益气活血中药联合骨髓间充质干细胞促进缺血性脑卒中血管新生的作用与机制[J]. 中国组织工程研究, 2021, 25(13): 2060-2069.
Fan Feiyan, Zhang Yunke. Effect and mechanism of traditional Chinese medicine for replenishing qi and promoting blood combined with bone marrow mesenchymal stem cells in promoting angiogenesis in ischemic stroke[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(13): 2060-2069.
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文题释义:#br# 骨髓间充质干细胞:是存在于骨髓中的具有高度自我更新能力和多向分化潜能的干细胞群体,具有支持造血、多向分化潜能以及在细胞和基因工程中具有潜在应用前景等特点。#br# 血管新生:是指在原有血管基础上通过血管内皮细胞增殖、芽生、游走、血管分裂和分支而形成新的毛细血管网,使其功能与局部需要相适应的生物学过程,主要过程包括:激活期血管基底膜降解;血管内皮细胞的激活、增殖、迁移;重建形成新的血管和血管网。#br#
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
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