中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (41): 6216-6224.doi: 10.3969/j.issn.2095-4344.2016.41.021

• 干细胞综述 stem cell review • 上一篇    下一篇

间充质干细胞在免疫调节过程中的作用与应用进展

易  桥1，2，卢燕勤1，2，黄宏宇1，2，周  典1，2，刘欧胜1，2   

  1. 1中南大学湘雅口腔医院，湖南省长沙市  410078
    2中南大学，湖南省长沙市  410078
  • 修回日期:2016-08-13 出版日期:2016-10-07 发布日期:2016-10-07
  • 通讯作者: 刘欧胜，博士，硕士生导师，中南大学，湖南省长沙市 410078；中南大学湘雅口腔医院，湖南省长沙市 410078
  • 作者简介:易桥，女，1989年生，湖南省怀化市人，瑶族，2016年中南大学毕业，硕士，主要从事牙源性干细胞研究。
  • 基金资助:

    中南大学中央高校基本科研业务费专项资金资助(2014zzts306)；国家自然科学基金(81300841)

Research progress in immunomodulatory properties of mesenchymal stem cells

Yi Qiao1, 2, Lu Yan-qin1, 2, Huang Hong-yu1, 2, Zhou Dian1, 2, Liu Ou-sheng1,2   

  1. 1Xiangya Stomatology Hospital, Central South University, Changsha 410078, Hunan Province, China
    2Central South University, Changsha 410078, Hunan Province, China
  • Revised:2016-08-13 Online:2016-10-07 Published:2016-10-07
  • Contact: Liu Ou-sheng, M.D., Master’s supervisor, Xiangya Stomatology Hospital, Central South University, Changsha 410078, Hunan Province, China; Central South University, Changsha 410078, Hunan Province, China
  • About author:Yi Qiao, Master, Xiangya Stomatology Hospital, Central South University, Changsha 410078, Hunan Province, China; Central South University, Changsha 410078, Hunan Province, China
  • Supported by:

    the Fundamental Research Funds for the Central Universities in Central South University, No. 2014zztx306; the National Natural Science Foundation of China, No. 81300841

PDF

270

被引次数

8

摘要：

文章快速阅读：

文题释义：
免疫调节：是指在免疫应答过程中免疫系统内部各细胞间、免疫细胞与免疫分子间以及免疫系统与神经内分泌系统间的相互作用，从而构成一个相互协助又相互制约的网络结构，使免疫应答维持合适的强度以保证机体内环境的稳定。
效应T细胞：具有释放淋巴因子的功能，T细胞接受抗原刺激后，经过增殖、分化，形成效应T细胞，在此过程中，有一小部分T细胞成为记忆细胞。

 

摘要
背景：间充质干细胞属于多能干细胞，能够从骨髓、脂肪、脐血等组织中分离而得。间充质干细胞对适应性免疫和固有免疫都具有免疫调节作用。
目的：综述间充质干细胞对T淋巴细胞、B淋巴细胞、NK细胞、树突状细胞的免疫调节作用及其临床应用前景。
方法：应用计算机检索2000至2015年PubMed和CNKI数据库相关文章，中文检索词为“间充质干细胞，免疫调节，T细胞，B细胞，NK细胞，树突状细胞”，英文检索词为“mesenchymal stem cells, immunomodulator, T cells, B cells, NK cells, dendritic cells”，从中筛选出与主题相关且论据可靠的文献，最终纳入61篇文献进行综述。
结果与结论：间充质干细胞可通过细胞接触和可溶性细胞因子对T淋巴细胞、B淋巴细胞、NK细胞、树突状细胞产生免疫调节作用。但是不同组织来源间充质干细胞的免疫调节不尽相同。在间充质干细胞的临床应用中，还需要考虑细胞分离方法、细胞来源、定植部位等重要因素。在间充质干细胞应用于临床之前，仍有许多问题有待进一步研究，以确保其安全性和有效性。

 

 

关键词: 干细胞, 移植, 间充质干细胞, 免疫调节, 综述, 临床应用, 国家自然科学基金

Abstract:

BACKGROUND: Mesenchymal stem cells are multipotent progenitor cells that can be isolated from the bone marrow, adipose tissue, umbilical cord blood and so on. Mesenchymal stem cells possess strong immunosuppressive effects on both innate and adaptive immunity.
OBJECTIVE: To summarize the immunomodulatory properties of mesenchymal stem cells for T lymphocytes, B lymphocytes, natural killer cells and dentritic cells and prospect its therapeutic implication.
METHODS: PubMed and CNKI databases were searched for relevant literatures published from 2000 to 2015. The key words were “mesenchymal stem cells, immunomodulator, T cells, B cells, NK cells, dendriticc cells” in Chinese and English, respectively. Then, 61 papers were included and further analyzed.
RESULTS AND CONCLUSION: The immunomodulatory effects of MSCs on lymphocytes, B lymphocytes, natural killer cells and dentritic cells were elicited by cell-cell contact and soluble cytokines. But mesenchymal stem cells from different sources hold different immunomodulatory effect on immune cells. When we use mesenchymal stem cells in clinic, some important factors, such as isolation methods, cell sources, colonization sites, should be taken into account. In order to ensure the clinical safety and effectiveness, there are still many problems to be further studied before mesenchymal stem cells can be widely used in clinic.

 

 

Key words: Mesenchymal Stem Cells, Immunomodulation, Review, Tissue Engineering

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