中国组织工程研究

中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (1): 137-142.doi: 10.3969/j.issn.2095-4344.2014.01.023

• 干细胞综述 stem cell review • 上一篇    下一篇

脂肪干细胞和生物支架应用于牙槽骨修复

曹  娜，裴  路，张  微   

  1. 哈尔滨医科大学附属第二临床医院牙体牙髓科，黑龙江省哈尔滨市  150086
  • 修回日期:2013-10-21 出版日期:2014-01-01 发布日期:2014-01-01
  • 通讯作者: 裴路，教授，哈尔滨医科大学附属第二临床医院牙体牙髓科，黑龙江省哈尔滨市150086
  • 作者简介:曹娜，女，1986年生，山东省汶上县人，汉族，哈尔滨医科大学在读硕士，主要从事口腔内科学方面的研究。
  • 基金资助:

    哈尔滨医科大学附属第二医院项目(D2007-10)

Adipose stem cells and biological scaffolds used in alveolar bone repair

Cao Na, Pei Lu, Zhang Wei   

  1. Department of Endodontics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
  • Revised:2013-10-21 Online:2014-01-01 Published:2014-01-01
  • Contact: Pei Lu, Professor, Department of Endodontics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
  • About author:Cao Na, Studying for master’s degree, Department of Endodontics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
  • Supported by:

    the Program of the Second Affiliated Hospital of Harbin Medical University, No. D2007-10

PDF

779

被引次数

6

摘要：

背景：各种生理或病理因素导致的牙槽骨的吸收、缺损是口腔临床医学中的常见问题，但目前较常用的修复缺损牙槽骨的方法不能完全满足临床需要。骨组织工程的出现成为修复骨缺损的研究热点。 
目的：就脂肪干细胞的来源和应用价值、生物支架的种类及特性、生物支架对种子细胞的影响及脂肪干细胞复合支架用于动物实验的研究等方面作一总结。
方法：应用计算机检索CNKI和Pubmed数据库中1995年1月至2013年4月关于脂肪干细胞、生物支架及骨修复的文章，在标题和摘要中以“脂肪干细胞，分化、增殖和成骨生物支架，牙槽骨，骨组织工程”或“Adipose stem cells，Differentiation、proliferation and Osteogenesis，Biological scaffold，alveolar bone，bone tissue engineering”为检索词进行检索。选择文章内容与脂肪干细胞和生物支架应用于修复骨缺损有关者，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到163篇文献，根据纳入标准选择关于脂肪干细胞和生物支架应用于修复骨缺损的40篇文献进行综述。
结果与结论：脂肪干细胞具有与骨髓基质干细胞相似的分化潜能，因其来源广、易采集、易培养低衰老，成骨分化好和风险小等特点被广泛关注，尤其和生物支架应用于骨修复表现出更好的成骨效果。随着有关各科学的发展牙槽骨缺损的修复有关问题都可以解决，脂肪干细胞和生物支架构建工程骨将是实现真正意义上牙槽骨再生的发展趋势且具有良好的发展前景。


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程


全文链接：

关键词: 干细胞, 脂肪干细胞, 骨髓干细胞, 牙槽骨, 生物支架, 骨组织工程, 骨缺损, 骨再生, 综述

Abstract:

BACKGROUND: Alveolar bone absorption and defect caused by various physiological or pathological factors is a common problem in oral clinical medicine, but the most commonly used methods to repair alveolar bone defects cannot fully meet clinical needs. The emergence of bone tissue engineering for bone defect repair has become a research hotspot.   
OBJECTIVE: To review the source and application of adipose stem cells, the types and characteristics of biological scaffolds, the effect of biological scaffold on seed cells and the application of adipose stem cells composite scaffolds in animal experiment research.
METHODS: A computer-based search of CNKI and PubMed (1995-01/2013-04) was performed to retrieve the related articles about adipose stem cells, biological scaffold and bone repair. The keywords were “adipose stem cells, differentiation, proliferation and osteogenesis, biological scaffold, alveolar bone, bone tissue engineering” in Chinese and English, respectively. Articles published recently or in authorized journals were preferred. There were163 articles after the initial survey. Then, 40 articles were included in result analysis.
RESULTS AND CONCLUSION: Adipose stem cells have a differentiating potential similar to bone marrow stromal stem cells. Adipose stem cells have been widely drawn by variety of sources, easy collection, easy to cultivate and low aging, good osteogenetic differentiation and low risk. Especially, adipose stem cells and biological scaffolds used in bone repair show better osteogenesis effect. With the development of science, problems related to alveolar bone defect repair can be solved. Adipose stem cells and biological scaffold for construction of tissue-engineered bone will be realized in the true sense of the alveolar bone regeneration, with good prospects for development.


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程


全文链接：

Key words: alveolar bone loss, bone regeneration, dental prosthesis repair, stents

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