中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (42): 7977-7980.doi: 10.3969/j.issn.2095-4344.2012.42.036

• 组织构建临床实践 clinical practice in tissue construction • 上一篇    

湖北籍汉族强直性脊柱炎患者白细胞介素1受体拮抗剂基因的多态性

游 浩1，程翠年1，张 卉1，李佳森2，李豫皖2，胡孝洪2，扈凤平2，周世力3，高劲松2   

  1. 1武汉市五医院，湖北省武汉市 430050
    2长沙医学院，湖南省长沙市 410219
    3江汉大学，湖北省武汉市 430056
  • 收稿日期:2012-02-10 修回日期:2012-03-26 出版日期:2012-10-14 发布日期:2012-10-14
  • 通讯作者: 高劲松，硕士，副教授，长沙医学院，湖南省长沙市 410219 gjs1968@126.com
  • 作者简介:游浩★，男，1969年生，湖北省人，汉族，1985年武汉大学医学院毕业，硕士，主任医师，副教授，硕士生导师，主要从事脊柱疾病的研究。 yourenyouyu2010@yahoo.cn

Polymorphisms of interleukin-1 receptor antagonist gene in ankylosing spondylitis patients who are Han nationality from Hubei Province

You Hao1, Cheng Cui-nian1, Zhang Hui1, Li Jia-sen2, Li Yu-wan2, Hu Xiao-hong2, Hu Feng-ping2, Zhou Shi-li3, Gao Jin-song2   

  1. 1The Fifth Hospital of Wuhan, Wuhan 430050, Hubei Province, China
    2Changsha Medical College, Changsha 410219, Hunan Province, China
    3Jianghan University, Wuhan 430056, Hunan Province, China
  • Received:2012-02-10 Revised:2012-03-26 Online:2012-10-14 Published:2012-10-14
  • Contact: Gao Jin-song, Master, Associate professor, Changsha Medical College, Changsha 410219, Hunan Province, China gjs1968@126.com
  • About author:You Hao★, Master, Chief physician, Associate professor Master’s supervisor, the Fifth Hospital of Wuhan, Wuhan 430050, Hubei Province, China yourenyouyu2010@yahoo.cn

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摘要：

背景：白细胞介素1是强直性脊柱炎易感基因之一，其多态性与疾病易感性相关，不同人群的研究结果不尽相同。
目的：分析中国湖北汉族人群中白细胞介素1受体拮抗剂基因多态性与强直性脊柱炎的相关性。
方法：自140名强直性脊柱炎患者及130名健康对照者外周血中提取DNA，采用PCR方法检测白细胞介素1受体拮抗剂基因第二内含子VNTR复等位基因多态性。所有受试者均为3代或3代以上居住于湖北的汉族人。
结果与结论：强直性脊柱炎患者中白细胞介素1受体拮抗剂基因*2等位基因频率显著高于健康对照者(P < 0.05)。提示强直性脊柱炎与白细胞介素1受体拮抗剂基因*2等位基因相关联。

关键词: 强直性脊柱炎, 基因, 多态性, 白细胞介素1受体拮抗剂基因, 湖北, 汉族

Abstract:

BACKGROUND: Interleukin 1 (IL-1) gene cluster contains a major susceptibility locus for ankylosing spondylitis. Its polymorphisms are correlated with the susceptibility of ankylosing spondylitis. The study results are often different in different population.
OBJECTIVE: To analyze the correlation between polymorphism of IL-1 receptor antagonist (IL-1RN) gene and patients with ankylosing spondylitis. The patients are the population of Han nationality of Hubei Province in China.
METHODS: DNA samples were collected from 140 patients with ankylosing spondylitis and 130 healthy as controls. The IL-1RN VNTR polymorphisms were determined by PCR method. All patients are of Han nationality and lived in Hubei Province for three generations at least.
RESULTS AND CONCLUSION: Compared with the healthy controls, IL-1RN VNTR*2 allelic frequency in patients with ankylosing spondylitis was significant higher (P < 0.05).

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