中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (42): 7972-7976.doi: 10.3969/j.issn.2095-4344.2012.42.035

• 组织构建临床实践 clinical practice in tissue construction • 上一篇    下一篇

健康人101名呼出一氧化氮正常值调查

李小娟，封继宏，孙增涛，魏葆琳，朱海燕   

  1. 天津中医药大学第二附属医院，天津市 300150
  • 收稿日期:2011-12-16 修回日期:2012-01-29 出版日期:2012-10-14 发布日期:2013-04-08
  • 作者简介:李小娟★，女，1978年生，河北省抚宁县人，汉族，2005年天津中医药大学毕业，硕士，主治医师，主要从事中西医结合呼吸内科，肺功能研究。 1978sys@sohu.com

Investigation of normal fractional exhaled nitric oxide value in 101 healthy people

Li Xiao-juan, Feng Ji-hong, Sun Zeng-tao, Wei Bao-lin, Zhu Hai-yan   

  1. Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China
  • Received:2011-12-16 Revised:2012-01-29 Online:2012-10-14 Published:2013-04-08
  • About author:Li Xiao-juan★, Master, Attending physician, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China 1978sys@sohu.com

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摘要：

背景：呼出一氧化氮测定可直接反映气道炎症，且具有无创、可重复性好、快速、患者依存性好等优点。
目的：调查健康正常人呼出一氧化氮正常值。
方法：使用瑞典尼尔斯(NIOX)《呼出一氧化氮测定系统》测定101名不同年龄段健康正常人呼出一氧化氮值，并测定肺通气功能及过敏原IgE。
结果与结论：101名健康正常人呼出一氧化氮值(5-58)×10-9，均值为18.119×10-9，正常范围为(7.674-28.564)×10-9；女性呼出一氧化氮值较男性低，51名女性均值为14.901×10-9，50名男性均值为21.400×10-9；呼出一氧化氮值与年龄无明显相关性，其中20-29岁及60-80岁两个阶段均值低于18.119×10-9，40-59年龄段均值最高，为21.3×10-9。性别及身高与呼出一氧化氮值存在明显相关性。表明本中心调查的101名健康正常人呼出一氧化氮值稍高于国际参考值，与性别、身高存在明显相关性。

关键词: 呼出一氧化氮, 正常值, 影响因素, 性别, 身高

Abstract:

BACKGROUND: Determination of fractional exhaled nitric oxide (FENO) can directly reflect airway inflammation. It is noninvasive, reproducible, rapid, and has good dependence in patients.
OBJECTIVE: To investigate FENO normal value in healthy people.
METHODS: Totally 101 different-age healthy people were measured EFNO with the NIOX Exhaled Nitric Oxide Monitoring System. Pulmonary ventilation function and allergen-IgE were measured.
RESULTS AND CONCLUSION: A total of 101 healthy people’s FENO value was (5-58)×10-9. Average FENO value was 18.119×10-9, and normal range was (7.674-28.564)×10-9. Lower FENO value was found in female compared with male. The mean value in 51 female was 14.901×10-9, and that in 50 male people was 21.400×10-9. FENO value had no significant correlation with ages. The mean value in 20 to 29 years old and 60 to 80 years old health people was lower than 18.119×10-9, and that of 40 to 59 years old people was 21.3×10-9 that was highest. There was significant correlation in FENO value between gender and height. These results suggest that the FENO values of these101 healthy people were slightly higher than those of international reference value, which have significant correlation between gender and height.

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