中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (38): 7057-7060.doi: 10.3969/j.issn.1673-8225.2011.38.007

• 膜生物材料 membrane biomaterials • 上一篇    下一篇

生物型补片修补中孕期胎羊腹壁缺损

孙俊杰1，汪凤华2，邓高燕2，汪  帕1，莫家骢1   

  1. 1中山大学附属第一医院小儿外科, 广东省广州市   510080
    2广州市妇女儿童医疗中心小儿外科, 广东省广州市   510120
  • 收稿日期:2011-01-19 修回日期:2011-03-11 出版日期:2011-09-17 发布日期:2011-09-17
  • 通讯作者: 莫家骢，博士，主任医师，博士导师，中山大学附属第一医院小儿外科, 广东省广州市 510080 pediatricsurgery@163.com
  • 作者简介:孙俊杰☆，男，1972年生，河南省许昌市人，汉族，2008年中山大学毕业，博士，主治医师，主要从事小儿外科研究。 sjjym@21cn.com
  • 基金资助:

    广东省科学技术厅科技项目（2008B060600030）。

Biomatrix patch for abdominal defect repair in the mid-trimester fetal lambs

Sun Jun-jie1, Wang Feng-hua2, Deng Gao-yan2, Wang Pa1, Mo Jia-cong1   

  1. 1Department of Pediatric Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou  510080, Guangdong Province, China
    2Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou  510120, Guangdong Province, China
  • Received:2011-01-19 Revised:2011-03-11 Online:2011-09-17 Published:2011-09-17
  • Contact: Mo Jia-cong, Doctor, Chief physician, Doctoral supervisor, Department of Pediatric Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China pediatricsurgery@163.com
  • About author:Sun Jun-jie☆, Doctor, Attending physician, Department of Pediatric Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China sjjym@21cn.com
  • Supported by:

    the Scientific Research Fund of Guangdong Science and Technology Bureau, No. 2008B060600030*

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摘要：

背景：腹裂在胚胎早期就已出现，由其引起的肠管损伤和功能障碍贯穿胎儿发育的全程。
目的：探讨在中孕期进行宫内手术修补胎羊腹壁缺损的可行性。
方法：取8只妊娠75~80 d的健康单胎妊娠山羊。将其分为两组，拉拢缝合组3只，采用拉拢缝合腹壁的方法修复胎羊腹壁的缺损。生物型膜片组5只，采用两层生物型膜片修补腹壁缺损。两组羔羊自然分娩，对其腹壁进行病理学检查。
结果与结论：拉拢缝合组3只羔羊均顺利娩出，3只羔羊腹壁切口愈合好，瘢痕呈线样，腹内粘连轻。组织切片上见瘢痕轻微。生物型膜片组5只中有1只流产，4只羔羊顺利娩出，4只羔羊腹壁切口愈合好，瘢痕明显，腹内粘连轻。组织切片上主要为纤维结缔组织。结果提示，在中孕期进行胎羊腹壁缺损是完全可行的。胎羊腹壁直接进行缝合者愈合后瘢痕轻微。对于皮肤缺损较大者，生物型修补膜片是一种可行性材料。

关键词: 腹壁缺损, 生物型补片, 胎儿, 动物模型, 腹裂, 羊

Abstract:

BACKGROUND: Gastroschisis is a rare and serious congenital abdominal wall defect disease, and often leads to the development imbalance between the intestine and abdominal cavity with inflammatory thickened bowel.
OBJECTIVE: To evaluate the feasibility of intrauterine abdominal defect repair of fetal lamb in the mid-trimester.
METHODS: Eight healthy pregnant ewes (at 75-80 days of gestation, with single fetus) were divided into 2 groups. Group 1 (3 lambs): the abdominal wall defect was closed by strengthening suture; Group 2 (5 lambs): the abdominal wall defect was repaired by two layers of biomatrix. After the lambs delivered naturally, the abdominal walls were examined pathologically.
RESULTS AND CONCLUSION: Three lambs of group 1 were successfully delivered, the abdominal incision healed well with a line-like scar, intra-abdominal adhesions was minor. A slight scar was seen on the tissue section. One lamb of the group 2 aborted, while 4 lambs delivered, the abdominal incision of the four lambs healed with obvious scar, intra-abdominal adhesions was minor. The fiber connective tissue was seen mainly on the tissue section. It was feasible to repair the abdominal wall defect of fetal lamb in mid-trimester. For fetal lamb, the abdominal wall scar was minor after direct suture. For larger abdominal wall defect, biomatrix patch was a promising material.

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