[1] LONGINETTI E, FANG F. Epidemiology of amyotrophic lateral sclerosis: an update of recent literature. Curr Opin Neurol. 2019;32(5):771-776.
[2] 贺韵涵,王强,孙嫘,等.肌萎缩侧索硬化症治疗的研究进展[J].现代中西医结合杂志,2020,29(6):679-684.
[3] HULISZ D. Amyotrophic lateral sclerosis: disease state overview. Am J Manag Care. 2018;24(15 Suppl):S320-S326.
[4] ZHAO W, BEERS DR, APPEL SH. Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis. J Neuroimmune Pharmacol. 2013;8(4):888-899.
[5] PARKER SE, HANTON AM, STEFANOU SN, et al. Revisiting the role of the innate immune complement system in ALS. Neurobiol Dis. 2019;127:223-232.
[6] 眭淑彦.肌萎缩侧索硬化症的中医病因病机探究[J].神经病学与神经康复学杂志,2014,11(3):130-132.
[7] 董阿茹汗,李竹庭,段建华.清热解毒类中药对免疫功能的影响研究进展[J].山西中医,2023,39(4):66-67,70.
[8] WU X, JIANG J, GU Z, et al. Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress. Stem Cell Res Ther. 2020;11(1):345.
[9] ABDUL WAHID SF, LAW ZK, ISMAIL NA, et al. Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev. 2019;12(12):CD011742.
[10] KWON MS, NOH MY, OH KW, et al. The immunomodulatory effects of human mesenchymal stem cells on peripheral blood mononuclear cells in ALS patients. J Neurochem. 2014;131(2):206-218.
[11] WANG Y, CHEN X, CAO W, et al. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol. 2014;15(11):1009-1016.
[12] BARBEITO AG, MESCI P, BOILLÉE S. Motor neuron-immune interactions: the vicious circle of ALS. J Neural Transm (Vienna). 2010;117(8):981-1000.
[13] 徐露,张太君.冰片联合灯盏花素对缺氧/复氧损伤血脑屏障通透性的影响[J].中国中医药信息杂志,2016,23(2):76-78.
[14] 丁煌,唐三,杨筱倩,等.冰片配伍黄芪甲苷与三七总皂苷对脑缺血/再灌注后血脑屏障通透性的影响[J].中国药理学通报,2019,35(11):1516-1523.
[15] 刘杨波,谌浩东,冯聚玲,等.人参皂苷Rg1对脑缺血再灌注损伤大鼠血脑屏障的保护作用[J].中国药学杂志,58(10):908-914.
[16] 司昕蕾,辛二旦,边甜甜,等.中药抗补体活性研究进展[J].中国中医药信息杂志,2019,26(6):136-139.
[17] 阮姝楠,卢燕,陈道峰.广藿香的抗补体活性成分[J].中国中药杂志,2013, 38(13):2129-2135.
[18] 沈路路,卢燕,程志红,等.虎杖的抗补体活性蒽醌类成分及其作用靶点[J].中草药,2013,44(18):2502-2507.
[19] 杜冬生,程志红,陈道峰.紫花地丁中的抗补体生物碱类成分研究[J].中国中药志,2017,42(24):4794-4800.
[20] LI YH, LIU SB, ZHANG HY, et al. Antioxidant effects of celastrol against hydrogen peroxide-induced oxidative stress in the cell model of amyotrophic lateral sclerosis. Sheng Li Xue Bao. 2017;69(6):751-758.
[21] YANG EJ, KIM SH, YANG SC, et al. Melittin restores proteasome function in an animal model of ALS. J Neuroinflammation. 2011;8:69.
[22] LEE KW, JI HM, KIM DW, et al. Effects of Hominis placenta on LPS-induced cell toxicity in BV2 microglial cells. J Ethnopharmacol. 2013;147(2):286-292.
[23] 丁旭苹,王雪,路丽明.中药天花粉蛋白增强诱导CD4+CD25+Foxp3+调节性T细胞数量和功能的初探[J].世界科学技术-中医药现代化,2021,23(11): 4097-4108.
[24] 裘冯卓,金庆文.T细胞调控及中药瞿麦在肌萎缩侧索硬化症治疗中的应用[J].中国临床神经科学,2021,29(2):224-231.
[25] 李建明,彭丽珊,刘显,等.复方扶芳藤合剂对免疫抑制小鼠NK细胞的调节作用研究[J/OL].沈阳药科大学学报:1-18[2023-04-10].
[26] GEUN KM, WON CS, YOOJIN S, et al. KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis. J Veter Sci. 2017;18(4):487-497.
[27] 张建,唐巍然.调节性T细胞与中草药的免疫调节[J].中国药业,2015,24(B12): 448-450.
[28] 张秋艳,王玲玲,张东蛟,等.肌萎灵冻干粉对运动神经元的保护作用[J]. 疑难病杂志,2011,10(3):197-200,247.
[29] GARBUZOVA-DAVIS S, KURIEN C, THOMSON A, et al. Endothelial and astrocytic support by human bone marrow stem cell grafts into symptomatic ALS mice towards blood-spinal cord barrier repair. Sci Rep. 2017;7(1):884.
[30] MONSOUR M, GARBUZOVA-DAVIS S, BORLONGAN CV. Patching up the permeability: the role of stem cells in lessening neurovascular damage in amyotrophic lateral sclerosis. Stem Cells Transl Med. 2022;11(12):1196-1209.
[31] ARTUS C, GLACIAL F, GANESHAMOORTHY K, et al. Couraud PO. The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells. J Cereb Blood Flow Metab. 2014;34(3):433-440.
[32] PARK HJ, SHIN JY, KIM HN, et al. Mesenchymal stem cells stabilize the blood-brain barrier through regulation of astrocytes. Stem Cell Res Ther. 2015;6:187.
[33] ODENWALD MA, CHOI W, BUCKLEY A, et al. ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. J Cell Sci. 2017;130(1):243-259.
[34] YARI H, MIKHAILOVA MV, MARDASI M, et al. Emerging role of mesenchymal stromal cells (MSCs)-derived exosome in neurodegeneration-associated conditions: a groundbreaking cell-free approach. Stem Cell Res Ther. 2022; 13(1):423.
[35] DÍAZ-FLORES L, GUTIÉRREZ R, MADRID JF, et al. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol. 2009;24(7):909-969.
[36] ROPPER AE, THAKOR DK, HAN I, et al. Defining recovery neurobiology of injured spinal cord by synthetic matrix-assisted hMSCs implantation. Proc Natl Acad Sci U S A. 2017;114(5):E820-E829.
[37] GARBUZOVA-DAVIS S, HALLER E, NAVARRO S, et al. Transplantation of human bone marrow stem cells into symptomatic ALS mice enhances structural and functional blood-spinal cord barrier repair. Exp Neurol. 2018;310:33-47.
[38] LOUSSOUARN C, PERS YM, BONY C, et al. Mesenchymal stromal cell-derived extracellular vesicles regulate the mitochondrial metabolism via transfer of miRNAs. Front Immunol. 2021;12:623973.
[39] 何锴琳,张航,王俊岭.外泌体在肌萎缩侧索硬化中的研究进展[J].临床与病理杂志,2019,39(8):1783-1789.
[40] THOMAS H, JÄGER M, MAUEL K, et al. Interaction with mesenchymal stem cells provokes natural killer cells for enhanced IL-12/IL-18-induced interferon-gamma secretion. Mediators Inflamm. 2014;2014:143463.
[41] OH JY, KIM H, LEE HJ, et al. MHC Class I enables MSCs to evade NK-Cell-mediated cytotoxicity and exert immunosuppressive activity. Stem Cells. 2022;40(9):870-882.
[42] ABBASI B, SHAMSASENJAN K, AHMADI M, et al. Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications. Stem Cell Res Ther. 2022;13(1):97.
[43] CHATTERJEE D, MARQUARDT N, TUFA DM, et al. Role of gamma-secretase in human umbilical-cord derived mesenchymal stem cell mediated suppression of NK cell cytotoxicity. Cell Commun Signal. 2014;12:63.
[44] SOTIROPOULOU PA, PEREZ SA, GRITZAPIS AD, et al. Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells. 2006;24(1):74-85.
[45] SHI Y, WANG Y, LI Q, et al. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol. 2018;14(8):493-507.
[46] LEE DK, SONG SU. Immunomodulatory mechanisms of mesenchymal stem cells and their therapeutic applications. Cell Immunol. 2018;326:68-76.
[47] PEDROSO JF, DE SOUZA VALIM V, PEZZI A, et al. An experimental study comparing the expansion of peripheral blood natural killer (NK) cells cultured with artificial antigen-presenting cells, in the presence or absence of bone marrow mesenchymal stem cells (MSCs). Mol Biotechnol. 2020;62(5):306-315.
[48] TU Z, LI Q, BU H, et al. Mesenchymal stem cells inhibit complement activation by secreting factor H. Stem Cells Dev. 2010;19(11):1803-1809.
[49] LI Y, FUNG J, LIN F. Local inhibition of complement improves mesenchymal stem cell viability and function after administration. Mol Ther. 2016;24(9):1665-1674.
[50] 肖昆太.人羊膜间充质干细胞静脉移植对ALS转基因小鼠免疫炎症调节作用研究[D].广州:南方医科大学,2018.
[51] 周葳. hUC-MSCs-exo对小胶质细胞增殖及炎性反应的调节作用[D].唐山:华北理工大学,2019.
[52] KIM SH, OH KW, JIN HK, et al. Immune inflammatory modulation as a potential therapeutic strategy of stem cell therapy for ALS and neurodegenerative diseases. BMB Rep. 2018;51(11):545-546.
[53] ZHANG Q, FU L, LIANG Y, et al. Exosomes originating from MSCs stimulated with TGF-β and IFN-γ promote Treg differentiation. J Cell Physiol. 2018;233(9):6832-6840.
[54] 郝磊,金戈,杨涌涛,等.骨髓间充质干细胞外泌体介导miR-124-1对小胶质细胞M2型极化调控的影响[J].上海交通大学学报(医学版),2022,42(3): 323-330.
[55] SUN H, BÉNARDAIS K, STANSLOWSKY N, et al. Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia. PLoS One. 2013;8(9):e72926.
[56] COQUE E, SALSAC C, ESPINOSA-CARRASCO G, et al. Cytotoxic CD8+ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons. Proc Natl Acad Sci U S A. 2019;116(6):2312-2317.
[57] LEE S, KIM S, CHUNG H, et al. Mesenchymal stem cell-derived exosomes suppress proliferation of T cells by inducing cell cycle arrest through p27kip1/Cdk2 signaling. Immunol Lett. 2020;225:16-22.
[58] MOKARIZADEH A, DELIREZH N, MORSHEDI A,et al. Dalir-Naghadeh B. Phenotypic modulation of auto-reactive cells by insertion of tolerogenic molecules via MSC-derived exosomes. Vet Res Forum. 2012 Fall;3(4):257-261.
[59] ZHOU Y, DAY A, HAYKAL S, et al. Mesenchymal stromal cells augment CD4+ and CD8+ T-cell proliferation through a CCL2 pathway. Cytotherapy. 2013;15(10): 1195-1207.
[60] WANG LT, JIANG SS, TING CH, et al. Differentiation of mesenchymal stem cells from human induced pluripotent stem cells results in downregulation of c-Myc and DNA replication pathways with immunomodulation toward CD4 and CD8 Cells. Stem Cells. 2018;36(6):903-914.
[61] BEERS DR, ZHAO W, WANG J, et al. ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity. JCI Insight. 2017;2(5):e89530.
[62] GHANNAM S, PÈNE J, MOQUET-TORCY G, et al. Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol. 2010;185(1):302-312.
[63] YAN Z, ZHUANSUN Y, CHEN R, et al. Immunomodulation of mesenchymal stromal cells on regulatory T cells and its possible mechanism. Exp Cell Res. 2014;324(1): 65-74.
[64] ENGELA AU, BAAN CC, PEETERS AM, et al. Interaction between adipose tissue-derived mesenchymal stem cells and regulatory T-cells. Cell Transplant. 2013; 22(1):41-54.
[65] ABDI J, RASHEDI I, KEATING A. Concise review: TLR pathway-miRNA interplay in mesenchymal stromal cells: regulatory roles and therapeutic directions. Stem Cells. 2018;36(11):1655-1662.
[66] NEGI N, GRIFFIN MD. Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance. Stem Cells. 2020;38(5):596-605.
[67] ZHANG J, MA X, CAO L, et al. Enhancing and stabilization of cord blood regulatory T-cell suppressive function by human mesenchymal stem cell (MSCs)-derived exosomes. Clin Exp Immunol. 2022;208(3):255-267.
[68] 张运克,车志英,李可.补阳还五汤联合骨髓间充质干细胞对脑缺血大鼠血脑屏障通透性的影响[J].中华中医药学刊,2019,37(7):1548-1553.
[69] 王继明,吴以岭,陈金亮,等.肌萎灵注射液对人骨髓基质细胞增殖和向神经细胞分化的影响[J].中国中医基础医学杂志,2007,13(10):768-770. |