[1] JIN ZB, GAO ML, DENG WL, et al. Stemming retinal regeneration with pluripotent stem cells. Prog Retin Eye Res. 2019;69:38-56.
[2] GASPARINI SJ, LLONCH S, BORSCH O, et al. Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives. Prog Retin Eye Res. 2019;69:1-37.
[3] ROSKA B, SAHEL JA. Restoring vision. Nature. 2018;557(7705):359-367.
[4] SCHOLL HP, STRAUSS RW, SINGH MS, et al. Emerging therapies for inherited retinal degeneration. Sci Transl Med. 2016;8(368):368rv6.
[5] PASCOLINI D, MARIOTTI SP. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96(5):614-618.
[6] GEHRS KM, ANDERSON DH, JOHNSON LV, et al. Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. Ann Med. 2006;38(7):450-471.
[7] DAMIANI D, NOVELLI E, MAZZONI F, et al. Undersized dendritic arborizations in retinal ganglion cells of the rd1 mutant mouse: a paradigm of early onset photoreceptor degeneration. J Comp Neurol. 2012;520(7):1406-1423.
[8] MAZZONI F, NOVELLI E, STRETTOI E. Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration. J Neurosci. 2008;28(52):14282-14292.
[9] SANTOS A, HUMAYUN MS, DE JUAN E JR, et al. Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Arch Ophthalmol. 1997;115(4):511-515.
[10] EHLKEN C, JUNGMANN S, BÖHRINGER D, et al. Switch of anti-VEGF agents is an option for nonresponders in the treatment of AMD. Eye (Lond). 2014;28(5):538-545.
[11] BURNIGHT ER, GIACALONE JC, COOKE JA, et al. CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration. Prog Retin Eye Res. 2018;65:28-49.
[12] VAN GELDER RN. Photochemical approaches to vision restoration. Vision Res. 2015;111(Pt B):134-141.
[13] WILKEN MS, REH TA. Retinal regeneration in birds and mice. Curr Opin Genet Dev. 2016;40:57-64.
[14] YAO K, QIU S, WANG YV, et al. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature. 2018; 560(7719):484-488.
[15] JORSTAD NL, WILKEN MS, GRIMES WN, et al. Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature. 2017; 548(7665):103-107.
[16] DA CRUZ L, FYNES K, GEORGIADIS O, et al. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018;36(4):328-337.
[17] JIN ZB, TAKAHASHI M. Generation of retinal cells from pluripotent stem cells. Prog Brain Res. 2012;201:171-181.
[18] MA Y, HAN X, DE CASTRO RB, et al. Analysis of the bystander effect in cone photoreceptors via a guided neural network platform. Sci Adv. 2018;4(5):eaas9274.
[19] LI Z, ZENG Y, CHEN X, et al. Neural stem cells transplanted to the subretinal space of rd1 mice delay retinal degeneration by suppressing microglia activation. Cytotherapy. 2016;18(6):771-784.
[20] LUI KO, BOYD AS, COBBOLD SP, et al. A role for regulatory T cells in acceptance of ESC-derived tissues transplanted across an major histocompatibility complex barrier. Stem Cells. 2010;28(10):1905-1914.
[21] PEARSON RA, BARBER AC, RIZZI M, et al. Restoration of vision after transplantation of photoreceptors. Nature. 2012;485(7396):99-103.
[22] LAMBA DA, KARL MO, WARE CB, et al. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci U S A. 2006;103(34):12769-12774.
[23] LAMBA DA, REH TA. Microarray characterization of human embryonic stem cell--derived retinal cultures. Invest Ophthalmol Vis Sci. 2011; 52(7):4897-4906.
[24] IKEDA H, OSAKADA F, WATANABE K, et al. Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci U S A. 2005;102(32):11331-11336.
[25] OSAKADA F, IKEDA H, MANDAI M, et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol. 2008;26(2):215-224.
[26] EIRAKU M, TAKATA N, ISHIBASHI H, et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature. 2011;472(7341): 51-56.
[27] NAKANO T, ANDO S, TAKATA N, et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell. 2012; 10(6):771-785.
[28] GONZALEZ-CORDERO A, WEST EL, Pearson RA, et al. Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nat Biotechnol. 2013;31(8):741-747.
[29] COLLIN J, ZERTI D, QUEEN R, et al. CRX Expression in Pluripotent Stem Cell-Derived Photoreceptors Marks a Transplantable Subpopulation of Early Cones. Stem Cells. 2019;37(5):609-622.
[30] SINGH R, CUZZANI O, BINETTE F, et al. Pluripotent Stem Cells for Retinal Tissue Engineering: Current Status and Future Prospects. Stem Cell Rev Rep. 2018;14(4):463-483.
[31] ZOU T, GAO L, ZENG Y, et al. Organoid-derived C-Kit+/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents. Nat Commun. 2019;10(1):1205.
[32] WEST EL, GONZALEZ-CORDERO A, HIPPERT C, et al. Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells. 2012;30(7):1424-1435.
[33] EBERLE D, SCHUBERT S, POSTEL K, et al. Increased integration of transplanted CD73-positive photoreceptor precursors into adult mouse retina. Invest Ophthalmol Vis Sci. 2011;52(9):6462-6471.
[34] LAKOWSKI J, HAN YT, PEARSON RA, et al. Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression. Stem Cells. 2011;29(9):1391-1404.
[35] LAKOWSKI J, GONZALEZ-CORDERO A, WEST EL, et al. Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell-Derived Self-Forming Retina. Stem Cells. 2015;33(8):2469-2482.
[36] LAKOWSKI J, WELBY E, BUDINGER D, et al. Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-Derived Retinal Organoids and Fetal Retinae. Stem Cells. 2018; 36(5):709-722.
[37] POSTEL K, BELLMANN J, SPLITH V, et al. Analysis of cell surface markers specific for transplantable rod photoreceptors. Mol Vis. 2013;19: 2058-2067.
[38] GAGLIARDI G, BEN M’BAREK K, GOUREAU O. Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: A pluripotent stem cell-based approach. Prog Retin Eye Res. 2019;71: 1-25.
[39] ASSAWACHANANONT J, MANDAI M, OKAMOTO S, et al. Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Reports. 2014; 2(5): 662-674.
[40] TU HY, WATANABE T, SHIRAI H, et al. Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration. EBioMedicine. 2019;39: 562-574.
[41] ZHONG X, GUTIERREZ C, XUE T, et al. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun. 2014;5:4047.
[42] MCLELLAND BT, LIN B, MATHUR A, et al. Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. Invest Ophthalmol Vis Sci. 2018; 59(6):2586-2603.
[43] SHIRAI H, MANDAI M, MATSUSHITA K, et al. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proc Natl Acad Sci U S A. 2016;113(1):E81-90.
[44] BARBER AC, HIPPERT C, DURAN Y, et al. Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci U S A. 2013; 110(1):354-359.
[45] LI T, LEWALLEN M, CHEN S, et al. Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells. Cell Res. 2013;23(6):788-802.
[46] SINGH MS, CHARBEL ISSA P, BUTLER R, et al. Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation. Proc Natl Acad Sci U S A. 2013;110(3):1101-1106.
[47] WARRE-CORNISH K, BARBER AC, SOWDEN JC, et al. Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina. Stem Cells Dev. 2014;23(9): 941-954.
[48] KINOUCHI R, TAKEDA M, YANG L, et al. Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin. Nat Neurosci. 2003;6(8):863-868.
[49] PEARSON RA, BARBER AC, WEST EL, et al. Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina. Cell Transplant. 2010;19(4): 487-503.
[50] WEST EL, PEARSON RA, TSCHERNUTTER M, et al. Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors. Exp Eye Res. 2008;86(4):601-611.
[51] KARL MO, REH TA. Regenerative medicine for retinal diseases: activating endogenous repair mechanisms. Trends Mol Med. 2010;16(4):193-202.
[52] KARL MO. The potential of stem cell research for the treatment of neuronal damage in glaucoma. Cell Tissue Res. 2013;353(2):311-325.
[53] VERARDO MR, LEWIS GP, TAKEDA M, et al. Abnormal reactivity of muller cells after retinal detachment in mice deficient in GFAP and vimentin. Invest Ophthalmol Vis Sci. 2008;49(8):3659-3665.
[54] CHEN LF, FITZGIBBON T, HE JR, et al. Localization and developmental expression patterns of CSPG-cs56 (aggrecan) in normal and dystrophic retinas in two rat strains. Exp Neurol. 2012;234(2):488-498.
[55] ROESCH K, STADLER MB, CEPKO CL. Gene expression changes within Müller glial cells in retinitis pigmentosa. Mol Vis. 2012;18:1197-1214.
[56] YAO J, TUCKER BA, ZHANG X, et al. Robust cell integration from co-transplantation of biodegradable MMP2-PLGA microspheres with retinal progenitor cells. Biomaterials. 2011;32(4):1041-1050.
[57] LEE ES, YU SH, JANG YJ, et al. Transplantation of bone marrow-derived mesenchymal stem cells into the developing mouse eye. Acta Histochem Cytochem. 2011;44(5):213-221.
[58] SUGITA S, MAKABE K, FUJII S, et al. Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models. Stem Cell Reports. 2017;9(5): 1501-1515.
[59] WEST EL, PEARSON RA, BARKER SE, et al. Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. Stem Cells. 2010;28(11):1997-2007.
[60] ZHU J, CIFUENTES H, REYNOLDS J, et al. Immunosuppression via Loss of IL2rγ Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina. Cell Stem Cell. 2017;20(3): 374-384.e5.
[61] MACLAREN RE, PEARSON RA, MACNEIL A, et al. Retinal repair by transplantation of photoreceptor precursors. Nature. 2006;444(7116): 203-207.
[62] BARTSCH U, ORIYAKHEL W, KENNA PF, et al. Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice. Exp Eye Res. 2008; 86(4):691-700.
|