中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (47): 8880-8884.doi: 10.3969/j.issn.2095-4344.2012.47.028

• 生物材料综述 biomaterial review • 上一篇    下一篇

骨移植支架材料的理论研究与临床应用

魏冀荣，章 莹   

  1. 解放军广州军区广州总医院骨科医院创伤骨科，广东省广州市 510010
  • 收稿日期:2012-03-16 修回日期:2012-04-11 出版日期:2012-11-18 发布日期:2012-11-18
  • 通讯作者: 章莹，博士，硕士生导师，主任医师，解放军广州军区广州总医院骨科医院创伤骨科，广东省广州市 510010
  • 作者简介:魏冀荣★，男，1985年生，山西省太原市人，汉族，2012年南方医科大学毕业，硕士，医师，主要从事骨缺损修复方面研究。 fimmutrumpet@ qq.com

Theoretical study and clinical application of bone graft materials

Wei Ji-rong, Zhang Ying   

  1. Department of Traumatic Orthopedics, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, Guangdong Province, China
  • Received:2012-03-16 Revised:2012-04-11 Online:2012-11-18 Published:2012-11-18
  • Contact: Zhang Ying, Ph.D., Master’s supervisor, Chief physician, Department of Traumatic Orthopedics, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, Guangdong Province, China
  • About author:Wei Ji-rong★, Master, Physician, Department of Traumatic Orthopedics, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, Guangdong Province, China fimmutrumpet@ qq.com

PDF

514

被引次数

22

摘要：

背景：骨移植是治疗骨缺损的重要方法，骨移植支架材料一直是骨科学的研究热点。
目的：综述骨移植支架材料的研究进展。
方法：应用计算机检索2000至2009年 CNKI(医学版)数据库和外文生物医学期刊整合系统中有关骨移植支架材料与骨缺损修复方面的文献。
结果与结论：理想的骨移植支架材料应具备的条件包括良好的生物相容性、生物可降解性、多孔三维立体结构、可塑性和一定的机械强度、骨诱导性、易消毒性。目前常见的骨移植支架材料基本归为自体骨、异体骨、异种骨、人工骨4类，重组合异种骨、组织工程骨等可归为异种骨及人工骨的衍生物。一些衍生物还可以复合抗生素等其他物质。尽管各类骨移植材料品类繁多，但各有优点与不足。临床治疗骨缺损，尤其大量或节段性骨缺损，迫切需要一种适宜的填充材料，作为最有潜力的异种骨移植，尚需进一步研究来评价其临床安全性及有效性。

关键词: 骨缺损, 异种骨, 骨移植, 支架材料, 综述

Abstract:

BACKGROUND: Bone grafting is an important method of treating bone defects, and bone graft materials have been an orthopedic focus for a long time.
OBJECTIVE: To review the progresses of bone graft materials.
METHODS: Literatures on bone graft materials and bone defect repairing published during 2000-2009 were searched in CNKI (Medical Edition) database and Foreign Medical Journals Full-text Service.
RESULTS AND CONCLUSION: The ideal bone graft materials should have good biocompatibility, biodegradability, three-dimensional structure, plasticity and certain strength, bone induction, and disinfection. At present, four types of materials are used: autogenous bone, allogeneic bone, xenogenic bone, and artificial bone. Reconstituted bone xenograft and tissue engineering bone belong to xenograft bone and artificial bone derivatives. Some derivatives can also be combined with antibiotics and other substances. Each of them has advantages and disadvantages. There is an urgent need for a suitable filling material in the clinical treatment of bone defects, especially large or segmental bone defects. Xenogeneic bone, with the widest application prospect, need further research to evaluate the efficacy and safety.

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