中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (31): 5848-5852.doi: 10.3969/j.issn.2095-4344.2012.31.031

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

细胞移植治疗顽固性癌痛

栗 晓，马 超   

  1. 中山大学孙逸仙纪念医院康复医学科，广东省广州市，510120
  • 收稿日期:2011-06-05 修回日期:2011-07-04 出版日期:2012-07-29 发布日期:2012-07-29
  • 通讯作者: 马超，博士，副主任医师，中山大学孙逸仙纪念医院康复医学科，广东省广州市 510120
  • 作者简介:栗晓★，女，1988年生，山西省河津市人，汉族，中山大学在读硕士，主要从事康复医学专业方面的研究。 lixiao204011987@sina.com

Cell transplantation for the treatment of refractory pain in cancer patients

Li Xiao, Ma Chao   

  1. Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
  • Received:2011-06-05 Revised:2011-07-04 Online:2012-07-29 Published:2012-07-29
  • Contact: Ma Chao, Doctor, Associate chief physician, Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
  • About author:Li Xiao★, Studying for master’s degree, Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China lixiao204011987@sina.com

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637

被引次数

1

摘要：

背景：寻找一些缓解癌痛的新方法，使癌症患者在延长其生存期的同时最大限度提高其生活质量是十分重要的。
目的：综述细胞移植治疗顽固性癌痛的现状及新进展。
方法：使用PubMed文献检索数据库及万方数据库，采用医学主题词检索，检索词为“脑啡肽；嗜铬细胞；PC12细胞；人嗜铬细胞瘤细胞；移植镇痛”，时间范围为2000-01/2011-08，语言限定为英文和中文。共检索到97篇文章，其中综述13篇，实验研究84篇。选择文章主要内容与细胞移植治疗顽固性癌痛直接相关的、针对性强、代表性好、相关领域权威杂志的文章共32篇进行综述。
结果与结论：细胞移植镇痛是治疗顽固性癌痛的一种新思路，动物实验及临床试验已经证实其镇痛效果。课题组开题首次提出PC12细胞移植镇痛的概念。前期的动物实验表明PC12细胞移植具有镇痛效果，并证实了其安全性。人嗜铬细胞瘤给镇痛提供了丰富的细胞来源，但是仍存在一些问题，需要进一步研究、探索。

关键词: 细胞移植镇痛, 癌痛, 嗜铬细胞, PC12细胞, 综述

Abstract:

BACKGROUND: It is necessary to explore a new way to ease the pain in cancer patients, because this is very important to extend their survival and maximally increase their living level.
OBJECTIVE: To review the status and advances of cell transplantation for refractory pain.
METHODS: PubMed and Wanfang databases were retrieved by computer for articles published from January 2000 to August 2011 with key words of “enkephalin, chromaffin cells, pheochromocytoma cells, human pheochromocytoma cells, transplantation analgesia” in English and Chinese, respectively. A total of 97 articles were retrieved containing 13 reviews and 84 experimental studies. Thirty-two articles directly related to cell transplantation for refractory pain and published in authoritative magazines were included to review.
RESULTS AND CONCLUSION: Cell transplantation is a new technique for treating the refractory pain. A lot of animal experiments and clinical trials have confirmed the analgesic effect. Pheochromocytoma cells transplantation to relieve the pain was introduced by our team, which has been demonstrated in the previous animal experiments. Human pheochromocytoma provides the source of cells for transplant therapy of the refractory pain. At the same time, there are lots of problems to be further solved and investigated.

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