中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (1): 153-157.doi: 10.3969/j.issn.1673-8225.2012.01.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脂肪组织源性干细胞分化为神经细胞及其治疗脑缺血的研究现状***

朱衍菲1，王琳琳1，董为人2   

  1. 1南方医科大学临床医学八年制研究生，广东省广州市  510515；2南方医科大学基础医学院组织学与胚胎学教研室，广东省广州市 510515
  • 收稿日期:2011-07-06 修回日期:2011-09-09 出版日期:2012-01-01 发布日期:2012-01-01
  • 通讯作者: 董为人，博士，教授，博士生导师，南方医科大学基础医学院组织学与胚胎学教研室，广东省广州市 510515 wrdong@163.com
  • 作者简介:朱衍菲，女，1987年生，上海市人，汉族，南方医科大学临床医学八年制在读。 fionaju515@gmail.com
  • 基金资助:

    广东省高校优秀中青年人才基金(C1010086)；佛山市科技攻关项目(201008063)；佛山市卫生局医学科研立项(2010177)。

Differentiation of adipose-derived stem cells into nerve cells and their transplantation for cerebral ischemia

Zhu Yan-fei1, Wang Lin-lin1, Dong Wei-ren2   

  1. 1Southern Medical University, Guangzhou  510515, Guangdong Province, China;2Department of Histology and Embryology, Basic Medical School, Southern Medical University, Guangzhou  510515, Guangdong Province, China
  • Received:2011-07-06 Revised:2011-09-09 Online:2012-01-01 Published:2012-01-01
  • Contact: Dong Wei-ren, Doctor, Professor, Doctoral supervisor, Department of Histology and Embryology, Basic Medical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China wrdong@163.com
  • About author:Zhu Yan-fei, Southern Medical University, Guangzhou 501515, Guangdong Province, China
  • Supported by:

    the Foundation of Talent Young Teachers of Guangdong Universities, No. C1010086*; the Tackle Key Program of Foshan City, No. 201008063*; Medical Disciplinary Project of Foshan Health Bureau, No. 2010177*

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摘要：

背景：源于中胚层的脂肪组织源性干细胞均具有多向分化潜能，在特殊的环境条件诱导下，可向神经细胞分化，移植到脑损伤动物模型可促进神经功能恢复。
目的：综述应用脂肪组织源性干细胞治疗缺血性脑损伤的研究现状，并对其存在的问题进行分析和展望。
方法：第一作者应用计算机检索2000-01/2011-02 PubMed数据库、CNKI数据库、维普数据库，中文检索词为“脂肪干细胞，分化，脑缺血”，英文检索词为“adipose-derived stem cells，adipose-tissue derived stem cells，adipose stem cells，differentiation，cerebral-ischemia”，共检索到175篇文献，最终纳入符合标准的文献34篇。
结果与结论：近年来不断有实验发现，脂肪组织源性干细胞可以在不同程度上改善缺血性脑损伤后的神经功能。但是迄今尚未见将脂肪组织源性干细胞诱导为成熟神经元的报道。如何在体内和诱导分化时准确地向神经细胞分化，是今后以脂肪组织源性干细胞治疗缺血性脑损伤的热点。

关键词: 脂肪干细胞, 神经细胞, 脑缺血, 移植, 分化, 综述文献

Abstract:

BACKGROUND: Adipose-derived stem cells (ADSCs) from the mesoderm have the potential of multiple differentiations. It can differentiate to neurons under specific environments and then transplant into animal models of cerebral ischemia which can enhance the recovery of neurological function.
OBJECTIVE: To make a review of ADSCs in the treatment of cerebral ischemia, and to analyze current problems and to prospect the future.
METHODS: PubMed, CNKI, CAJ were retrieved by computer with keywords of “adipose-derived stem cells, adipose-tissue derived stem cells, adipose stem cells, differentiation, cerebral ischemia”. The language was limited for English and Chinese. The literatures included clinical research, basic research, and reviews. Repetitive researches were excluded, and 34 documents of them were involved for further analysis.
RESULTS AND CONCLUSION: In recent years, many researches show that ADSCs can promote the neurological function after cerebral ischemia in different degree. But by now there is no report that ADSCs can be induced to mature neurons. How to differentiate to neurons accurately in vivo is a focus of ADSCs in the treatment of cerebral ischemia.

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