中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (2): 351-355.doi: 10.3969/j.issn.1673-8225.2011.02.040

• 组织构建综述 tissue construction review • 上一篇    下一篇

血小板衍化生长因子在细胞增殖和组织修复中的作用及机制

谢爱国1，梁红伟2，谭  谦3   

  1. 1南京医科大学第二附属医院烧伤整形外科，江苏省南京市 210011
    2 郑州市人民医院整形外科，河南省郑州市450003
    3南京大学医学院附属鼓楼医院整形外科，江苏省南京市  210008
  • 收稿日期:2010-08-16 修回日期:2010-10-23 出版日期:2011-01-08 发布日期:2011-01-08
  • 作者简介:谢爱国★，男，1982年生，江苏省南京市人，汉族，硕士，医师，主要从事组织损伤修复的基础与临床研究方面的研究。 dr.aigo@yahoo.com.cn
  • 基金资助:

    南京医科大学科技发展基金项目(09NJMUM 025)。

Role and mechanism of platelet-derived growth factor in cell proliferation and tissue repair  

Xie Ai-guo1, Liang Hong-wei2, Tan Qian3   

  1. 1Department of Burns and Plastic Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing  210011, Jiangsu Province, China
    2Department of Plastic Surgery, Zhengzhou People’s Hospital, Zhengzhou  450003, Henan Province, China
    3Department of Plastic Surgery, Drum Tower Hospital, Medical College of Nanjing University, Nanjing  210008, Jiangsu Province, China
  • Received:2010-08-16 Revised:2010-10-23 Online:2011-01-08 Published:2011-01-08
  • About author:Xie Ai-guo★, Master, Physician, Department of Burns and Plastic Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China dr.aigo@yahoo.com.cn
  • Supported by:

    the Science Development Foundation of Nanjing Medical University, No. 09NJMUM 025

PDF

429

被引次数

24

摘要：

背景：细胞增殖和组织修复是一个复杂的过程，这期间有大量生长因子参与，并且这些因子在发挥本身功效时，同时还相互影响和制约，从而更好地促进细胞增殖和组织修复。
目的：总结血小板衍化生长因子在细胞增殖和组织修复愈合过程中发挥的作用及其机制。
方法：检索PubMed数据库、EMbase数据库1960-01/2010-10期间相关文章，检索词为“platelet-derived growth factor，cell proliferation，tissue repair”。同时检索中国生物医学文献数据库、中文科技期刊全文数据库、中文学术期刊全文数据库2000-01/2010-10期间相关文章，检索词为“血小板衍化生长因子”。
结果与结论：血小板衍化生长因子是一种重要的促细胞分裂剂，可刺激各种类型细胞的分裂增殖。血小板衍化生长因子及其受体存在于机体的多种组织细胞，当机体受到一定的刺激时，血小板衍化生长因子与其受体结合，发挥作用，因此许多研究发现，在外科手术后和损伤修复过程中常伴随有局部血小板衍化生长因子基因表达量的升高和受体的上调，被称为损伤修复因子。但是它的具体作用机制尚不太明确，对细胞组织的增殖修复的认识还处于起始、发展阶段，还有许多的问题需要去探索研究。

关键词: 血小板衍化生长因子, 细胞增殖, 组织修复, 综述

Abstract:

BACKGROUND: Cell proliferation and tissue repair is a complicated process, accompanied by participation of multiple growth factors, and these factors from a system in which they play their roles not in an independent, but interacting and inter-restricting manner. 
OBJECTIVE: To summarize the role and mechanism of platelet-derived growth factor (PDGF) in cell proliferation and tissue repair.
METHODS: PubMed, EMbase, Chinese Biomedical Literature Database, CNKI, CAJ were retrieved by computer with keywords of “platelet-derived growth factor, cell proliferation, tissue repair”. The language was limited for English and Chinese.
RESULTS AND CONCLUSION: PDGF is one of the major mitogens and is responsible for proliferation and migration of various cells. PDGF and its receptors located in multiple tissues and cells, which combined with receptors and play its role when the body suffered certain stimulation. Thus, plenty of studies showed that the expression of PDGF gene was increased in the period of surgery or damage repair. The biological characteristics of PDGF have been recognized primarily. The specific mechanism of repair is not clarified and many problems need to be explored in further study.

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