中国组织工程研究

中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (7): 1112-1117.doi: 10.12307/2024.102

• 干细胞综述 stem cell review • 上一篇    下一篇

自噬在毛发再生中的作用

黄雨馨1，梁文姿1，陈秀文1，倪  娜1，赵颖琳2，林常敏1   

  1. 1汕头大学医学院，广东省汕头市   515041；2汕头大学精神卫生中心，广东省汕头市   515065
  • 收稿日期:2022-12-07 接受日期:2023-03-06 出版日期:2024-03-08 发布日期:2023-07-17
  • 通讯作者: 林常敏，教授，博士生导师，汕头大学医学院，广东省汕头市 515041
  • 作者简介:黄雨馨，女，1998年生，安徽省合肥市人，汉族，汕头大学在读硕士，主要从事组织工程化毛囊方面的研究。
  • 基金资助:
    国家自然科学基金资助项目(007-41369023)，项目负责人：林常敏

Role of autophagy in hair regeneration

Huang Yuxin1, Liang Wenzi1, Chen Xiuwen1, Ni Na1, Zhao Yinglin2, Lin Changmin1   

  1. 1Medical College, Shantou University, Shantou 515041, Guangdong Province, China; 2Mental Health Center, Shantou University, Shantou 515065, Guangdong Province, China
  • Received:2022-12-07 Accepted:2023-03-06 Online:2024-03-08 Published:2023-07-17
  • Contact: Lin Changmin, Professor, Doctoral supervisor, Medical College, Shantou University, Shantou 515041, Guangdong Province, China
  • About author:Huang Yuxin, Master candidate, Medical College, Shantou University, Shantou 515041, Guangdong Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 007-41369023 (to LCM)

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摘要：


文题释义：

自噬：是一种进化保守的过程，将真核生物胞内有毒蛋白质和废弃细胞器包裹起来，运送至溶酶体中降解。自噬的主要功能是降解内源性大分子物质，从而实现蛋白质、糖类、脂类物质在生物体内的再循环，在营养缺乏时，自噬有助于维持细胞内环境稳态和生存。
毛囊再生：是毛囊干细胞和毛乳头细胞交互作用的产物，其中毛囊干细胞是形成新生毛囊的主要细胞来源，然而毛乳头细胞则是通过影响信号通路的传导调节毛囊再生过程，两者相辅相成、缺一不可。


背景：在生物医学界，自噬是一个快速发展的研究热点，许多研究人员正在积极探究多种疾病中自噬的分子调控机制，但是自噬在毛发生长中所起的作用仍存在许多未知。

目的：综述目前自噬在毛发生长与再生中的研究进展及应用价值，了解自噬在毛发生长中的作用，以探究自噬在病理性脱发中的发病机制，为研究治疗脱发的药物提供新思路。
方法：应用计算机在中国知网(CNKI)、PubMed数据库中，以“毛囊生长，毛发生长，毛发再生，自噬相关蛋白，自噬活性，自噬相关基因，自噬”或“hair growth，hair follicle，hair regeneration，autophagy”为检索词进行检索。查阅国内外近年来关于自噬、毛发生长和自噬在毛发生长中作用的研究进展进行总结，排除与文章主题内容不相符的文献，最终纳入78篇文献进行结果分析。

结果与结论：①自噬是真核生物的正常代谢过程，具有复杂的分子机制和功能特性，既有利于细胞生存，又可促进细胞死亡。②脱发相关疾病与自噬活性的改变有关，且自噬活性可调控毛发生长周期；敲除或过表达自噬相关基因可改变毛发生长状态，已发现有多条自噬相关信号通路与毛囊生长有关；自噬的激活剂或抑制剂可用于治疗或预防脱发疾病。

https://orcid.org/0000-0003-2472-9018 (黄雨馨) 

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 毛囊, 毛发, 毛发再生, 毛囊再生, 毛囊生长周期, 自噬, 自噬活性, 自噬激活剂, 自噬抑制剂

Abstract: BACKGROUND: Autophagy has become a rapidly developing research hotspot in the biomedical fields. Many researchers are actively exploring the molecular regulatory mechanism of autophagy in a variety of diseases. However, the role of autophagy in hair growth is still unknown. 
OBJECTIVE: To review the current research progress and application value of autophagy in hair growth and regeneration, to understand the role of autophagy in hair growth, to explore the pathogenesis of autophagy in pathological hair loss, and to provide new ideas for the study of drugs for hair loss.
METHODS: Using “hair follicle growth, hair growth, hair regeneration, autophagy associated proteins, autophagy activity, autophagy associated genes, autophagy” as Chinese search terms and “hair growth, hair follicle, hair regeneration, autophagy” as English search terms, PubMed and CNKI databases were searched. The research progress on autophagy, hair growth and the role of autophagy in hair growth in and outside China in recent years was reviewed and summarized. Articles incompatible with the subject content of the paper were excluded. Finally, 78 articles were included for the result analysis.
RESULTS AND CONCLUSION: (1) Autophagy is a normal metabolic process in eukaryotes with complex molecular mechanisms and functional properties, which is beneficial to cell survival and cell death. (2) Alopecia-related diseases are associated with changes in autophagy activity, which can regulate hair growth cycle. Knockout or overexpression of autophagy-related genes can change the state of hair growth. Multiple autophagy related signaling pathways have been found to be related to hair follicle growth. Activators or inhibitors of autophagy can be used to treat or prevent hair loss.

Key words: hair follicle, hair, hair regeneration, hair follicle regeneration, hair follicle growth cycle, autophagy, autophagy activity, autophagy activator, autophagy inhibitor

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