[1] ROSS AK, COUTINHO DE ALMEIDA R, RAMOS YFM, et al. The miRNA-mRNA interactome of murine induced pluripotent stem cell-derived chondrocytes in response to inflammatory cytokines. FASEB J. 2020;34(9):11546-11561.
[2] WANG K, XU J, CAI J, et al.SerumleveIsofinterIeu-kin-l7 and adiponectina reassociated with in frapa-tellarfatpad volumeand signal intensity alteration inpatients with knee osteoarthritis. Arthritis Res Ther. 2016;(18):193.
[3] LOESER RF. The Role of Aging in the Development of Osteoarthritis. Trans Am Clin Climatol Assoc. 2017;128:44-54.
[4] WANG T, HAO Z, LIU C, et al. LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway. Cell Death Dis. 2020;11(7):598.
[5] MENDEII JT. MicroRNAs:critical regulatorsofdeveI-opment,cellularphysiology and malignancy. Cell Cycle. 2005;4(9):1179-1184.
[6] KOPAŃSKA M, SZALA D, CZECH J, et al. MiRNA expression in the cartilage of patients with osteoarthritis. J Orthop Surg Res. 2017;12(1):51.
[7] HUSSAIN SM, DAWSON C, WANG Y, et al. Vascular Pathology and Osteoarthritis: A Systematic Review. J Rheumatol. 2020;47(5):748-760.
[8] NIELSEN FK, EGUND N, JØRGENSEN A, et al. Risk factors for joint replacement in knee osteoarthritis; a 15-year follow-up study. BMC Musculoskelet Disord. 2017;18(1):510.
[9] LEE RC, FEINBAUM RL, AMBROS V. The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843-854.
[10] ENGELS BM, HUTVAGNER G. Principles and effects of microRNA-mediated post-transcriptional gene regulation. Oncogene. 2006;25(46):6163-6169.
[11] Soltanzadeh-Yamchi M, Shahbazi M, Aslani S, et al. MicroRNA signature of regulatory T cells in health and autoimmunity. Biomed Pharmacother. 2018; 100:316-323.
[12] Giraldez AJ, Mishima Y, Rihel J, et al. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science. 2006;312(5770):75-79.
[13] Filipowicz W, Jaskiewicz L, Kolb FA, et al. Post-transcriptional gene silencing by siRNAs and miRNAs. Curr Opin Struct Biol. 2005;15(3):331-341.
[14] Wang J, Chen J, Sen S. MicroRNA as Biomarkers and Diagnostics. J Cell Physiol. 2016;231(1):25-30.
[15] Valinezhad Orang A, Safaralizadeh R, Kazemzadeh-Bavili M. Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. Int J Genomics. 2014;2014:970607.
[16] Soyocak A, Kurt H, Ozgen M, et al. miRNA-146a, miRNA-155 and JNK expression levels in peripheral blood mononuclear cells according to grade of knee osteoarthritis. Gene. 2017;627:207-211.
[17] Rasheed Z, Al-Shobaili HA, Rasheed N, et al. Integrated study of globally expressed microRNAs in IL-1β-stimulated human osteoar- thritis chondrocytes and osteoarthritis relevant genes: a microarray and bioinformatics analysis.Nucleosides Nucleotides Nucleic Acids. 2016;35(7):335-355.
[18] IUOPOULOS D, MALIZOS K N, OIKONOMOU P, et al. lntegrative microRNA and proteomic approaches identify novel osthritis gen and their collaborative metabolic and inflammatory networks. PLoS One. 2008;3(11):e3740.
[19] JONES SW, WATKINS G, LE GOOD N, et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF - alpha and MMP13. Osteoarthritis Cartilage. 2009;17(4):464-472.
[20] ZHANG Z, KANG Y, ZHANG Z, et al. Expression of microRNAs during chondrogenesis of human adipose-derived stem cells. Osteoarthritis Cartilage. 2012;20(12):1638-1646.
[21] WANG GL, WU YB, LIU JT, et al. Upregulation of miR-98 Inhibits Apoptosis in Cartilage Cells in Osteoarthritis.Genet Test Mol Biomarkers. 2016;20(11):645-653.
[22] WANG T, HAO Z, LIU C, et al. MiR-193b modulates osteoarthritis progression through targeting ST3GAL4 via sialylation of CD44 and NF-кB pathway. Cell Signal. 2020;76:109814.
[23] ZHANG G, SUN Y, WANG Y, et al. MiR-502-5p inhibits IL-1β-induced chondrocyte injury by targeting TRAF2. Cell Immunol. 2016;302:50-57.
[24] SONG J, JIN EH, KIM D, et al. MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis. Bba Clinical. 2015;3(1):79-89.
[25] DÍAZ-PRADO S, CICIONE C, MUIÑOS-LÓPEZ E, et al. Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes. BMC Musculoskelet Disord. 2012;13:144.
[26] CAO P, FENG Y, DENG M, et al. MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2. Osteoarthritis Cartilage. 2019;27(2):336-346.
[27] ZHANG W, HSU P, ZHONG B, et al. MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway. Cell Physiol Biochem. 2018;48(3):1304-1316.
[28] LU J, ZHOU Z, SUN B, et al. MiR-520d-5p modulates chondrogenesis and chondrocyte metabolism through targeting HDAC1.Aging (Albany NY). 2020; 12(18):18545-18560.
[29] TU M, LI Y, ZENG C, et al. MicroRNA-127-5p regulates osteopontin expression and osteopontin-mediated proliferation of human chondrocytes. Rep. 2016;6:25032.
[30] SHEN PF, QU YX, WANG B, et al. miR-30a-5p promotes the apoptosis of chondrocytes in patients with osteoarthritis by targeting protein kinase B. Zhonghua Yi Xue Za Zhi. 2017;97(39):3079-3084.
[31] CHEN L, LI Q, WANG J, et al. MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN. J Cell Mol Med. 2017;21(12):3347-3359.
[32] YAN S, WANG M, ZHAO J, et al. MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis. Int J Mol Med. 2016;38(1):201-209.
[33] LI X, HE P, LI Z, et al. Interleukin 1β mediated suppression of microRNA 27a 3p activity in human cartilage via MAPK and NF κB pathways: A potential mechanism of osteoarthritis pathogenesis. Mol Med Rep. 2018;18(1):541-549.
[34] MIYAKI S, SATO T, INOUE A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010;24(11):1173-1185.
[35] JI Q, XU X, ZHANG Q, et al. The IL-1β/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis. J Mol Med. 2016;94(7): 771-785.
[36] WANG G, ZHANG Y, ZHAO X, et al. MicroRNA-411 inhibited matrix metalloproteinase 13 expression in human chondrocytes. Am J Trans Res. 2015; 7(10):2000-2006.
[37] ZHANG H, SONG B, PAN Z. Downregulation of microRNA-9 increases matrix metalloproteinase-13 expression levels and facilitates osteoarthritis onset. Mol Med Rep. 2018;17(3):3708-3714.
[38] CHOI AM, RYTER SW, LEVINE B. Autophagy in Human Health and Disease. N Engl J Med. 2013;368(7):651-662.
[39] LEVINE B, KROEMER G. Autophagy in the pathogenesis of disease. Cell. 2008;132: 27-42.
[40] BERGAMINI E, CAVALLINI G, DONATI A, et al. The role of autophagy in aging. Ann N Y Acad Sci. 2010;1114(1):69-78.
[41] WANG ZJ, ZHANG HB, CHEN C, et al. Effect of PPARG on AGEs-induced AKT/MTOR signaling-associated human chondrocytes autophagy. Cell Biol Int. 2018;42(7): 841-848.
[42] DE FIGUEROA PL, LOTZ MK, BLANCO FJ, et al.Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976.
[43] WAN G, XIE W, LIU Z, et al. Hypoxia- induced\r,MIR155\r, is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014; 10(1):70-79.
[44] CHEN Z, JIN T, LU Y. AntimiR- 30b Inhibits TNF- α Mediated Apoptosis and Attenuated Cartilage Degradation through Enhancing Autophagy. Cell Physiol Biochem. 2016;40(5):883-894.
[45] D”ADAMO S, CETRULLO S, GUIDOTTI S, et al. Hydroxytyrosol modulates the levels of microRNA- 9 and its target sirtuin- 1 thereby counteracting oxidative stress- induced chondrocyte death. Osteoarthritis Cartilage. 2017;25(4):600-610.
[46] SUN W, LI Y, WEI S. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Exp Ther Med. 2018;15(1):1119-1128.
[47] ZHANG FQ, WANG Z, ZHANG H, et al. MiR-27a alleviates osteoarthritis in rabbits via inhibiting inflammation. Eur Rev Med Pharmacol Sci. 2019;23(3 Suppl):89-95.
[48] ZHANG G, ZHOU Y, SU M, et al. Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5. Biofactors. 2020;46(5):788-802.
[49] WILSON C, KRIEG AJ. KDM4B: A Nail for Every Hammer? Genes (Basel). 2019; 10(2):134.
[50] KIRKPATRICK JE, KIRKWOOD KL, WOSTER PM. Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics. 2018;13(5):557-572.
[51] WANG JH, SHIH KS, WU YW, et al. Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fibroblast-like synoviocytes. Osteoarthritis Cartilage. 2013;21(12):1987-1996.
[52] LOESER RF, COLLINS JA, DIEKMAN BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(7):412-420.
[53] MOUW JK, OU G, WEAVER VM. Extracellular matrix assembly: a multiscale deconstruction. Nat Rev Mol Cell Biol. 2014;15(12):771-785.
[54] KANG D, SHIN J, CHO Y, et al. Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development. Sci Transl Med. 2019;11(486):eaar6659.
[55] LIU X, GAO F, WANG W, et al. Expression of miR-204 in patients with osteoarthritis and its damage to chondrocytes. J Musculoskelet Neuronal Interact. 2020;20(2): 265-271.
[56] UKAI T, SATO M, AKUTSU H, et al. MicroRNA-199a-3p,microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism.Orthop Res. 2012;30(12):1915-1922.
[57] PEFFERS MJ. Transcriptomic signatures in cartilage ageing. Arthritis Res Ther. 2013;21(4):1-17.
[58] YUAN Y, ZHANG GQ, CHAI W, et al. Silencing of microRNA-138-5p promotes IL-1β-induced cartilage degradation in human chondrocytes by targeting FOXC1: miR-138 promotes cartilage degradation. Bone Joint Res. 2016;5(10):523-530.
[59] MANNE U, SHANMUGAM C, BOVELL L, et al. miRNAs as biomarkers for man-agement of patients with colorectal cancer. Biomark Med. 2010;4(5):761-770.
[60] IUOPOULOS D, MALIZOS K N, OIKONOMOU P, et al. lntegrative microRNA and proteomic approaches identify novel osthritis gen and their collaborative metabolic and inflammatory networks. PLoS One. 2008;3(11): e3740.
[61] SOYOCAK A, KURT H, OZGEN M, et al. miRNA-146a, miRNA-155 and JNK expression levels in peripheral blood mononuclear cells according to grade of knee osteoarthritis. Gene. 2017;627:207-211.
[62] 顾宗欣,王五洲.微小RNA对骨关节炎发生发展影响的研究进展[J].实用骨科杂志,2017,23(12):1102-1105.
[63] LIOPOULOS D, MALIZOS KN, OIKONOMOU P, et al. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One. 2008;3(11):e3740.
[64] CHAO Y, ZHANG L, ZHANG X, et al. Expression of miR-140 and miR-199 in synovia and its correlation with the progression of knee osteoarthritis. Med Sci Monit. 2020;26:e918174.
[65] ŞAHIN Ş, TUNCEL SA, SALIMI K, et al. Advanced Injectable Alternatives for Osteoarthritis. Adv Exp Med Biol. 2018;1077:183-196.
[66] YAN KS, LIN CY, LIAO TW, et al. EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe? Int J Mol Sci. 2017;18(6):1172.
[67] YAMAGISHI M, UCHIMARU K. Targeting EZH2 in cancer therapy. Curr Opin Oncol. 2017;29(5):375-381.
[68] LI Y, YUAN F, SONG Y, et al. miR-17-5p and miR-19b-3p prevent osteoarthritis progression by targeting EZH2. Exp Ther Med. 2020;20(2):1653-1663.
[69] PAN H, DAI H, WANG L, et al. MicroRNA-410-3p modulates chondrocyte apoptosis and inflammation by targeting high mobility group box 1 (HMGB1) in an osteoarthritis mouse model. BMC Musculoskelet Disord. 2020;21(1):486.
[70] LIU XC, XU L, CAI YL, et al. MiR-1207-5p/CX3CR1 axis regulates the progression of osteoarthritis via the modulation of the activity of NF-κB pathway. Int J Rheum Dis. 2020;23(8):1057-1065.
[71] SI HB, ZENG Y, LIU SY, et al. Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats. Osteoarthritis Cartilage. 2017;25(10):1698-1707.
[72] BAEK D, LEE KM, PARK KW, et al. Inhibition of miR-449a Promotes Cartilage Regeneration and Prevents Progression of Osteoarthritis in In Vivo Rat Models.Mol Ther Nucleic Acids. 2018;13:322-333.
[73] WANG X, GUO Y, WANG C, et al. MicroRNA-142-3p Inhibits Chondrocyte Apoptosis and Inflammation in Osteoarthritis by Targeting HMGB1. Inflammation. 2016;39(5):1718-1728.
[74] WANG H, ZHANG H, SUN Q, et al. Intra- articular Delivery of Antago- miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. MolTher. 2017;25(3):715-727.
[75] KANG L, YANG C, SONG Y, et al. MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes. Biochem Biophys Res Commun. 2016;478(1):467-473.
[76] HONVO G, REGINSTER JY, RABENDA V, et al. Safety of Symptomatic Slow-Acting Drugs for Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.Drugs Aging. 2019;36(Suppl 1):65-99. |