中国组织工程研究

中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (12): 1957-1962.doi: 10.3969/j.issn.2095-4344.2014.12.025

• 生物材料综述 biomaterial review • 上一篇    下一篇

不同人工骨材料复合骨髓间充质干细胞治疗早期股骨头坏死：争议与进展

毕  鑫，李多玉，杨  毅，龚跃昆，李  彪   

  1. 昆明医科大学第一附属医院骨科，云南省昆明市  650032
  • 修回日期:2014-02-06 出版日期:2014-03-19 发布日期:2014-03-19
  • 通讯作者: 龚跃昆，主任医师，硕士生导师，昆明医科大学第一附属医院骨科，云南省昆明市 650032
  • 作者简介:毕鑫，男，1987年生，云南省保山市人，汉族，在读硕士，主要从事关节外科学习研究。
  • 基金资助:

    云南省应用基础研究(昆医联合专项)(2013FB144)

Different artificial bones combined with bone marrow mesenchymal stem cell therapy for early osteonecrosis of the femoral head: controversy and progress

Bi Xin, Li Duo-yu, Yang Yi, Gong Yue-kun, Li Biao   

  1. Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • Revised:2014-02-06 Online:2014-03-19 Published:2014-03-19
  • Contact: Gong Yue-kun, Chief physician, Master’s supervisor, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • About author:Bi Xin, Studying for master’s degree, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • Supported by:

    the Applied Basic Research of Yunnan Province, No. 2013FB144

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摘要：

背景：临床上采用复合骨髓间充质干细胞的人工骨组织材料治疗早期股骨头坏死取得了一定进展。
目的：综述骨髓间充质干细胞的生物学性能及运用其复合不同人工骨组织治疗早期股骨头坏死的研究进展。
方法：应用计算机检索2003至2013年PubMed数据库、FMJS数据库，2005至2013年万方数据库、CNKI数据库及CBM数据库，检索关键词分别为“bone marrow mesenchymal stem cells，artificial bone，osteonecrosis of the femoral head；骨髓间充质干细胞，人工骨，股骨头坏死”。
结果与结论：应用骨髓间充质干细胞分别复合天然人工骨、珊瑚人工骨、羟基磷灰石人工骨、钙-磷生物陶瓷人工骨及硫酸钙人工骨等治疗股骨头坏死，可降低坏死股骨头内压力，促进局部毛细血管的修复并改善股骨头血供，促进成骨细胞分化增殖等，最终起到延缓甚至避免人工关节置换治疗。但仍有许多问题有待解决，包括干细胞治疗股骨头坏死病理机制的研究还有待进一步深入；由于个体差异、取材部位、体外培养技术等不同，种子细胞的数量和质量存在明显差异性；目前人工骨组织材料还处于探索研发阶段，运用骨髓间充质干细胞复合人工骨组织材料治疗股骨头坏死缺乏大样本随机对照研究，其远期疗效缺乏随访观察统计，并且适应证的选择及疗效评价标准、手术认知度等缺乏统一量化的标准。


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

关键词: 生物材料, 骨生物材料, 人工骨, 骨髓间充质干细胞, 股骨头坏死, 综述

Abstract:

BACKGROUND: Clinically, bone marrow mesenchymal stem cells combined with artificial bones for early osteonecrosis of the femoral head have a wonderful outcome.
OBJECTIVE: To review the biological properties of bone marrow mesenchymal stem cells and to summarize the application progress of bone marrow mesenchymal stem cells combined with different artificial bones in the treatment of early osteonecrosis of the femoral head.
METHODS: PubMed (2003-2013), FMJS (2003-2013), Wanfang (2005-2013), CNKI (2005-2013) and CBM (2005-2013) databases were retrieved by computer using the keywords of “bone marrow mesenchymal stem cells; artificial bone; osteonecrosis of the femoral head” in Chinese and English.
RESULTS AND CONCLUSION: It will lower the pressure of the femoral head, accelerate repair of the blood capillary, improve the blood supply, osteoblast proliferation and differentiation, and thus delay or even prevent artificial joint replacement after osteonecrosis of the femoral head by applying bone marrow mesenchymal stem cells combined with different artificial bones, such as corlline hydroxyapatite, calcium hydroxylaptite, biological ceramics and calcium sulfate bones. But now, there are still a lot of problems which need to be solved, including pathological mechanism underlying bone marrow mesenchymal stem cells for treatment of osteonecrosis of the femoral head, obvious difference between the quantity and quality of seed cells because of individual difference, different sites and culture techniques. So, artificial bone materials are under review, and large-sample randomized control trials are required. Its long-term outcomes also lack for follow-up observation, as well as there is no a unified quantitative standard for the appropriate selection of indication, curative effect evaluation and the awareness of the operation.


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

Key words: biocompatible materials, stem cells, femur head necrosis, review

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