中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (10): 1620-1624.doi: 10.12307/2022.213

• 生物材料综述 biomaterial review • 上一篇    下一篇

生物材料与组织工程技术在鼓膜缺损重建中的应用

文  科1,卢彦青1,侯  楠1,马瑞娜2,崔鹏程2,吕  蝶1,徐小丽1   

  1. 1成都医学院临床医学院•第一附属医院,四川省成都市   610000;2中国人民解放军空军军医大学,陕西省西安市   710032
  • 收稿日期:2020-09-07 修回日期:2020-09-09 接受日期:2020-12-07 出版日期:2022-04-08 发布日期:2021-10-27
  • 通讯作者: 侯楠,副教授,硕士生导师,成都医学院临床医学院•第一附属医院,四川省成都市 610000
  • 作者简介:文科,男,1983年生,四川省成都市人,汉族,主治医师,主要从事耳鼻咽喉头颈外科研究。 卢彦青,女,1994年生,重庆市人,汉族,成都医学院在读硕士,主要从事组织工程耳鼻喉修复重建研究。
  • 基金资助:
    四川省科技厅基金重点研发项目(19ZDYF0944),项目负责人:侯楠

Application of biomaterial and tissue engineering in reconstruction of tympanic membrane defect

Wen Ke1, Lu Yanqing1, Hou Nan1, Ma Ruina2, Cui Pengcheng2, Lü Die1, Xu Xiaoli1   

  1. 1Clinical Medical College and First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China; 2The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
  • Received:2020-09-07 Revised:2020-09-09 Accepted:2020-12-07 Online:2022-04-08 Published:2021-10-27
  • Contact: Hou Nan, Associate professor, Master’s supervisor, Clinical Medical College and First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China
  • About author:Wen Ke, Attending physician, Clinical Medical College and First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China Lu Yanqing, Master candidate, Clinical Medical College and First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China Wen Ke and Lu Yanqing contributed equally to this article.
  • Supported by:
    the Key Research and Development Project of Sichuan Provincial Department of Science and Technology, No. 19ZDYF0944 (to HN)

摘要: 文题释义:
鼓膜穿孔:儿童多因为其解剖因素(咽鼓管短平粗)使得上呼吸道感染后导致中耳炎,从而鼓膜穿孔,多因直接或间接外力损伤所致。中耳炎导致的鼓膜穿孔后可引起一过性耳痛,患者先有耳部疼痛,鼓膜穿孔后疼痛可减轻,耳内可有液体流出。外伤导致的鼓膜破裂后,患者突感耳痛,听力立即减退伴耳鸣,外耳道少量出血和耳内闷胀感。
组织工程:通过使用特定的生长因子或是相应的细胞植入具有良好生物相容性、可降解性和可吸收的生物材料,以用于修复缺损部位。

背景:利用组织工程技术修补穿孔鼓膜可有效减少术后并发症的发生。
目的:综述用于鼓膜穿孔修补材料的研究进展。
方法:应用计算机检索PubMed、Web of science、万方及中国知网等数据库,英文文献期限为2000-2020年,中文文献期限为2018-2020年,检索英文关键词为“tympanic membrane,acute/chronic tympanic membrane perforation,tissue engineering”, 检索中文关键词为“鼓膜穿孔,组织工程”。最后总结各方法的临床可行性及修补预后。
结果与结论:鼓膜穿孔可导致听力下降及耳部反复流脓,严重影响患者的生活质量。组织工程技术用于修补鼓膜是一种趋势,在避免了取自体组织材料所带来风险的前提下,组织工程材料修补的鼓膜也可具备原始鼓膜的功能及结构。鼓膜修补的组织工程包括三大要素:种子细胞、支架材料(为细胞扩增、迁移、分化提供机械支撑)、生物活性物质(为组织生长提供合适的微环境)。组织工程材料可减少获取自身组织作为修补材料所带来的感染及血肿等风险,也可根据鼓膜穿孔的情况选择修补材料,为修补鼓膜提供了新的研究方向及治疗方案。

https://orcid.org/0000-0002-9048-5501 (文科) 

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料口腔生物材料纳米材料缓释材料材料相容性;组织工程

关键词: 材料, 鼓膜穿孔, 鼓膜修补, 组织工程, 生物材料, 综述

Abstract: BACKGROUND: The use of tissue engineering technology to repair perforated tympanic membrane can effectively reduce the incidence of postoperative complications.
OBJECTIVE: To review the research progress of repairing materials for tympanic membrane perforation.
METHODS: The computer was used to retrieve databases, including PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure. English literature published from 2000 to 2020 and Chinese literature published from 2018 to 2020 were retrieved. Key words in English were “tympanic membrane, acute/chronic tympanic membrane perforation, tissue engineering”; key words in Chinese were “tympanic membrane perforation, tissue engineering”. Finally, the clinical feasibility and repair prognosis of each method were summarized.
RESULTS AND CONCLUSION: Tympanic membrane perforation can lead to hearing loss and repeated ear abscess, affecting the quality of life to patients seriously. Tissue engineering technology is a trend to repair tympanic membrane perforation, which can also have the function and structure of the original tympanic membrane without the risk of being taken from autologous materials. Tissue engineering of tympanic membrane repair includes three elements: seed cells, scaffold materials (providing mechanical support for cell expansion, migration and differentiation), and bioactive substances (providing suitable microenvironment for tissue growth). Tissue engineering materials can reduce the risk of infection and hematoma caused by acquiring autologous tissues as repairing materials, and can also be selected according to the situation of tympanic membrane perforation, which provides a new research directions and treatment solutions for repairing tympanic membrane.

Key words: material, tympanic membrane perforation, tympanic membrane repair, tissue engineering, biomaterial, review

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