[1] SACITHARAN PK. Ageing and Osteoarthritis. Subcell Biochem. 2019;91:123-159.
[2] BLANCO FJ, REGO I, RUIZ-ROMERO C. The role of mitochondria in osteoarthritis. Nat Rev Rheumatol. 2011;7(3):161-169.
[3] WANG Y, WEI L, ZENG L, et al. Nutrition and degeneration of articular cartilage. Knee Surg Sports Traumatol Arthrosc. 2013;21(8):1751-1762.
[4] BEEKHUIZEN M, BASTIAANSEN-JENNISKENS YM, KOEVOET W, et al. Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture. Arthritis Rheum. 2011;63(7):1918-1927.
[5] MORELLI AM, RAVERA S, PANFOLI I. The aerobic mitochondrial ATP synthesis from a comprehensive point of view. Open Biol. 2020;10(10):200224.
[6] ZHENG L, ZHANG Z, SHENG P, et al. The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. Ageing Res Rev. 2021;66: 101249.
[7] LANE RS, FU Y, MATSUZAKI S, et al.Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Res Ther. 2015;17(1):54.
[8] AIZAH N, CHONG PP, KAMARUL T. Early Alterations of Subchondral Bone in the Rat Anterior Cruciate Ligament Transection Model of Osteoarthritis. Cartilage. 2019:1947603519878479.
[9] LEPETSOS P, PAPAVASSILIOU AG. Ros/oxidative stress signaling in osteoarthritis. Biochim Biophys Acta. 2016;1862(4):576-591.
[10] TEIXEIRA G, SZYNDRALEWIEZ C, MOLANGO S, et al. Therapeutic potential of NADPH oxidase 1/4 inhibitors. Br J Pharmacol. 2017;174(12):1647-1669.
[11] REED KN, WILSON G, PEARSALL A, et al. The role of mitochondrial reactive oxygen species in cartilage matrix destruction. Mol Cell Biochem. 2014;397(1-2):195-201.
[12] OHASHI Y, TAKAHASHI N, TERABE K, et al. Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis. Sci Rep. 2021;11(1):15131.
[13] KOIKE M, NOJIRI H, OZAWA Y,et al.Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration. Sci Rep. 2015;25(5):11722.
[14] FU Y, KINTER M, HUDSON J, et al Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis. Arthritis Rheumatol. 2016;68(8):1887-1898.
[15] WANG Y, ZHAO X, LOTZ M, et al. Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Arthritis Rheumatol. 2015;67(8):2141-2153.
[16] LIU Z, ZHANG H, WANG H, et al. Magnolol Alleviates IL-1β-Induced Dysfunction of Chondrocytes Through Repression of SIRT1/AMPK/PGC-1α Signaling Pathway. J Interferon Cytokine Res. 2020;40(3):145-151.
[17] PICCA A, MANKOWSKI RT, BURMAN JL, et al. Mitochondrial quality control mechanisms as molecular targets in cardiac ageing. Nat Rev Cardiol. 2018;15(9): 543-554.
[18] WANG Y, CHEN LY, LIU-BRYAN R. Mitochondrial Biogenesis, Activity, and DNA Isolation in Chondrocytes. Methods Mol Biol. 2021;2245:195-213.
[19] ANDREUX PA, HOUTKOOPER RH, AUWERX J. Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov. 2013;12(6):465-483.
[20] CHEN LY, WANG Y, TERKELTAUB R,et al. Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function. Osteoarthritis Cartilage. 2018;26(11):1539-1550.
[21] TORRENS-MAS M, PONS DG, SASTRE-SERRA J, et al. SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ros Production. J Cell Biochem. 2017;118(2):397-406.
[22] YANG F, LI B, YANG Y, et al. Leptin enhances glycolysis via OPA1-mediated mitochondrial fusion to promote mesenchymal stem cell survival. Int J Mol Med. 2019;44(1):301-312.
[23] BLANCO FJ, FERNÁNDEZ-MORENO M. Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis. Osteoarthritis Cartilage. 2020;28(8):1003-1006.
[24] WANG FS, KUO CW, KO JY, et al. Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy. Antioxidants (Basel). 2020;9(9):810.
[25] KIM D, SONG J, KANG Y, et al. Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function. J Mol Med (Berl). 2016;94(12): 1373-1384.
[26] ZHOU J, SHI M, LI M, et al. Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis. Cell Stress Chaperones. 2019;24(2):369-383.
[27] PARK J, CHOI H, MIN JS, et al. Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells. J Neurochem. 2013;127(2):221-232.
[28] LÓPEZ DE FIGUEROA P, LOTZ MK, BLANCO FJ, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976.
[29] WANG S, DENG Z, MA Y, et al. The Role of Autophagy and Mitophagy in Bone Metabolic Disorders. Int J Biol Sci. 2020;16(14):2675-2691.
[30] ANSARI MY, HAQQI TM. Assessing Chondrocyte Status by Immunofluorescence-Mediated Localization of Parkin Relative to Mitochondria. Methods Mol Biol. 2021;2245:215-224.
[31] ANSARI MY, KHAN NM, AHMAD I, et al. Parkin clearance of dysfunctional mitochondria regulates ros levels and increases survival of human chondrocytes. Osteoarthritis Cartilage. 2018;26(8):1087-1097.
[32] SHIN HJ, PARK H, SHIN N, et al. Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis. J Clin Med. 2019;8(11): 1849.
[33] WANG C, YANG Y, ZHANG Y, et al. Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes. Biosci Trends. 2019;12(6):605-612.
[34] MAIMAITIJUMA T, YU JH, REN YL, et al. PHF23 negatively regulates the autophagy of chondrocytes in osteoarthritis. Life Sci. 2020;253:117750.
[35] LI H, SLONE J, FEI L, et al. Mitochondrial DNA Variants and Common Diseases: A Mathematical Model for the Diversity of Age-Related mtDNA Mutations. Cells. 2019;8(6):608.
[36] WALLACE DC. Genetics: Mitochondrial DNA in evolution and disease. Nature. 2016;535(7613):498-500.
[37] FERNÁNDEZ-MORENO M, SOTO-HERMIDA A, VÁZQUEZ-MOSQUERA ME, et al. Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in oaI and CHECK cohorts. A meta-analysis and functional study. Ann Rheum Dis. 2017;76(6):1114-1122.
[38] SOTO-HERMIDA A, FERNÁNDEZ-MORENO M, OREIRO N, et al. mtDNA haplogroups and osteoarthritis in different geographic populations. Mitochondrion. 2014;15:18-23.
[39] FANG H, LIU X, SHEN L, et al. Role of mtDNA haplogroups in the prevalence of knee osteoarthritis in a southern Chinese population. Int J Mol Sci. 2014;15(2): 2646-2659.
[40] REGO-PÉREZ I, BLANCO FJ, ROEMER FW, et al. Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis. Osteoarthritis Cartilage. 2018;26(11):1562-1569.
[41] YIN S, ZHANG L, DING L, et al. Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction. J Inflamm (Lond). 2018;15:27.
[42] NASI S, CASTELBLANCO M, CHOBAZ V, et al. Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage. Front Cell Dev Biol. 2021;9:612440.
[43] TERKELTAUB R, YANG B, LOTZ M, et al. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. Arthritis Rheum. 2011;63(7): 1928-1937.
[44] PETURSSON F, HUSA M, JUNE R, et al. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. Arthritis Res Ther. 2013;15(4):R77.
[45] SCOTT JL, GABRIELIDES C, DAVIDSON RK, et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Ann Rheum Dis. 2010;69(8):1502-1510.
[46] GAVRIILIDIS C, MIWA S, VON ZGLINICKI T, et al. Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2. Arthritis Rheum. 2013;65(2):378-387.
[47] MA CH, CHIUA YC, WU CH, et al. Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis. Redox Biol. 2018;15:504-512.
[48] CETRULLO S, D’ADAMO S, GUIDOTTI S, et al. Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms. Biochim Biophys Acta. 2016;1860(6):1181-1191.
[49] HOSSEINZADEH A, KAMRAVA SK, JOGHATAEI MT, et al. Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin. J Pineal Res. 2016;61(4):411-425.
[50] BORIN TF, ARBAB AS, GELALETI GB, et al. Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. J Pineal Res. 2016;60(1):3-15.
[51] WANG J, WANG K, HUANG C, et al. SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis. Int J Biol Sci. 2018;14(13):1873-1882.
[52] QIU L, LUO Y, CHEN X. Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in oa rats. Biomed Pharmacother. 2018;103:1585-1591.
[53] LIU C, CAO Y, YANG X, et al. Tauroursodeoxycholic acid suppresses endoplasmic reticulum stress in the chondrocytes of patients with osteoarthritis. Int J Mol Med. 2015;36(4):1081-1087.
[54] SAUD SM, LI W, GRAY Z, et al. Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF-κB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β. Cancer Prev Res (Phila). 2016;9(7):607-615.
[55] YI H, ZHANG W, CUI ZM, et al. Resveratrol alleviates the interleukin-1β-induced chondrocytes injury through the NF-κB signaling pathway. J Orthop Surg Res. 2020;15(1):424.
[56] SHAO X, CHEN Q, DOU X, et al. Lower range of molecular weight of xanthan gum inhibits cartilage matrix destruction via intrinsic bax-mitochondria cytochrome c-caspase pathway. Carbohydr Polym. 2018;98:354-363.
[57] SUN Y, ZHANG G, LIU Q, et al. Chondroitin sulfate from sturgeon bone ameliorates pain of osteoarthritis induced by monosodium iodoacetate in rats. Int J Biol Macromol. 2018;117:95-101.
[58] LIU Q, WANG J, SUN Y, et al. Chondroitin sulfate from sturgeon bone protects chondrocytes via inhibiting apoptosis in osteoarthritis. Int J Biol Macromol. 2019; 134:1113-1119.
[59] HUANG Y, WU D, FAN W. Protection of ginsenoside Rg1 on chondrocyte from IL-1β-induced mitochondria-activated apoptosis through PI3K/Akt signaling. Mol Cell Biochem. 2014;392(1-2):249-257.
[60] MASUDA I, KOIKE M, NAKASHIMA S, et al. Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes. Sci Rep. 2018;8(1):7229.
[61] WANG L, SHAN H, WANG B, et al. Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 Signaling Pathway in Osteoarthritis Rats. Pharmacology. 2018; 102(3-4):117-125.
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