[1] MEYER K, PALMER JW. The polysaccharide of the vitreous humor. J Biol Chem. 1934;107:629-634.
[2] IANNITTI T, LODI D, PALMIERI B. Intra-articular injections for the treatment of osteoarthritis: focus on the clinical use of hyaluronic acid. Drugs R D. 2011; 11(1):13-27.
[3] Poole CA. Articular cartilage chondrons: form, function and failure. J Anat. 1997;191(Pt 1):1-13.
[4] 胥少汀,葛宝丰,许印坎. 实用骨科学[M].4版.北京:人民军医出版社, 2012:48.
[5] LAURENT TC, FRASER JR. Hyaluronan. FASEB J. 1992;6(7):2397-2404.
[6] ONO Y, SAKAI T, HIRAIWA H, et al. Chondrogenic capacity and alterations in hyaluronan synthesis of cultured human osteoarthritic chondrocytes. Biochem Biophys Res Commun. 2013;435(4):733-739.
[7] NISHIDA Y, KNUDSON CB, NIETFELD JJ, et al. Antisense inhibition of hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention and matrix assembly. J Biol Chem. 1999;274(31):21893-21899.
[8] MATSUMOTO K, LI Y, JAKUBA C, et al. Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Development. 2009;136(16):2825-2835.
[9] HUANG Y, ASKEW EB, KNUDSON CB, et al. CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention. Matrix Biol. 2016;56:74-94.
[10] KAROUSOU E, MISRA S, GHATAK S, et al. Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol. 2017;59:3-22.
[11] KNUDSON CB. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix.J Cell Biol. 1993;120(3):825-834.
[12] KNUDSON CB, NOFAL GA, PAMINTUAN L, et al. The chondrocyte pericellular matrix: a model for hyaluronan-mediated cell-matrix interactions. Biochem Soc Trans. 1999;27(2):142-147.
[13] KNUDSON W, AGUIAR DJ, HUA Q, et al. CD44-anchored hyaluronan-rich pericellular matrices: an ultrastructural and biochemical analysis. Exp Cell Res. 1996;228(2):216-228.
[14] MAROUDAS A, BAYLISS MT, UCHITEL-KAUSHANSKY N, et al. Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age. Arch Biochem Biophys. 1998;350(1):61-71.
[15] Morales TI, Hascall VC. Correlated metabolism of proteoglycans and hyaluronic acid in bovine cartilage organ cultures. J Biol Chem. 1988;263(8):3632-3628.
[16] HIGUCHI Y, NISHIDA Y, KOZAWA E, et al. Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model. Scientific reports. 2017;7(1):7028.
[17] EMBRY JJ, KNUDSON W. G1 domain of aggrecan cointernalizes with hyaluronan via a CD44-mediated mechanism in bovine articular chondrocytes. Arthritis and rheumatism. 2003;48(12):3431-3441.
[18] STERN R. Devising a pathway for hyaluronan catabolism: are we there yet? Glycobiology. 2003;13(12):105R-15R.
[19] MCGUIRE PG, CASTELLOT JJ JR, ORKIN RW. Size-dependent hyaluronate degradation by cultured cells. J Cell Physiol. 1987;133(2):267-276.
[20] HOLMES MW, BAYLISS MT, MUIR H. Hyaluronic acid in human articular cartilage. Age-related changes in content and size. Biochem J. 1988;250(2):435-441.
[21] DURIGOVA M, ROUGHLEY PJ, MORT JS. Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M. Osteoarthritis Cartilage. 2008;16(1):98-104.
[22] DURIGOVA M, TROEBERG L, NAGASE H, et al. Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage. Eur Cell Mater. 2011;21:31-45.
[23] FOSANG AJ, TYLER JA, HARDINGHAM TE. Effect of interleukin-1 and insulin like growth factor-1 on the release of proteoglycan components and hyaluronan from pig articular cartilage in explant culture. Matrix. 1991;11(1):17-24.
[24] CHUBINSKAYA S, CS-SZABO G, KUETTNER KE. ADAM-10 message is expressed in human articular cartilage. J Histochem Cytochem. 1998;46(6):723-729.
[25] GUILAK F, ALEXOPOULOS LG, UPTON ML, et al. The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Ann N Y Acad Sci. 2006;1068:498-512.
[26] HAN L, GRODZINSKY AJ, ORTIZ C. Nanomechanics of the Cartilage Extracellular Matrix. Annu Rev Mater Res. 2011;41:133-168.
[27] NIA HT, HAN L, BOZCHALOOI IS, et al. Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. ACS Nano. 2015;9(3):2614-29625.
[28] PREIN C, WARMBOLD N, FARKAS Z, et al. Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy. Matrix Biol. 2016;50:1-15.
[29] TOOLE BP, WIGHT TN, TAMMI MI. Hyaluronan-cell interactions in cancer and vascular disease.J Biol Chem. 2002;277(7):4593-4596.
[30] AVENOSO A, D’ASCOLA A, SCURUCHI M, et al. Hyaluronan in the experimental injury of the cartilage: biochemical action and protective effects. Inflamm Res. 2018;67(1):5-20.
[31] ARIYOSHI W, TAKAHASHI N, HIDA D, et al. Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides. Arthritis and rheumatism. 2012;64(1):187-197.
[32] NISHIDA Y, KNUDSON CB, KUETTNER KE, et al. Osteogenic protein-1 promotes the synthesis and retention of extracellular matrix within bovine articular cartilage and chondrocyte cultures. Osteoarthritis Cartilage. 2000;8(2):127-136.
[33] OHNO S, IM HJ, KNUDSON CB, et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. J Biol Chem. 2006;281(26):17952-17960.
[34] JIANG D, LIANG J, FAN J, et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005;11(11):1173-1139.
[35] DONG Y, ARIF A, OLSSON M, et al. Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-alpha, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages. Scientific reports. 2016;6:36928.
[36] IACOB S, KNUDSON CB. Hyaluronan fragments activate nitric oxide synthase and the production of nitric oxide by articular chondrocytes. Int J Biochem Cell Biol. 2006;38(1):123-133.
[37] LIU-BRYAN R, PRITZKER K, FIRESTEIN GS, et al. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J Immunol. 2005;174(8):5016-5023.
[38] LUO N, KNUDSON W, ASKEW EB, et al. CD44 and hyaluronan promote the bone morphogenetic protein 7 signaling response in murine chondrocytes. Arthritis Rheumatol. 2014;66(6):1547-1558.
[39] GUPTA RC, LALL R, SRIVASTAVA A, et al. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192.
[40] TAKAHASHI K, HASHIMOTO S, KUBO T, et al. Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model.J Orthop Res. 2001;19(3):500-503.
[41] SASAKI A, SASAKI K, KONTTINEN YT, et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. Tohoku J Exp Med. 2004;204(2):99-107.
[42] ALTMAN RD, MANJOO A, FIERLINGER A, et al. The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review. BMC musculoskeletal disorders. 2015;16:321.
[43] NGUYEN C, RANNOU F. The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review. Expert Opin Drug Saf. 2017; 16(8):897-902.
[44] XU X, JHA AK, HARRINGTON DA,et al. Hyaluronic Acid-Based Hydrogels: from a Natural Polysaccharide to Complex Networks. Soft Matter. 2012;8(12):3280-3294.
[45] BURDICK JA, PRESTWICH GD. Hyaluronic acid hydrogels for biomedical applications. Adv Mater. 2011;23(12):H41-56.
[46] CUBUKCU D, ARDIC F, KARABULUT N, et al. Hylan G-F 20 efficacy on articular cartilage quality in patients with knee osteoarthritis: clinical and MRI assessment. Clin Rheumatol. 2005;24(4):336-341.
[47] Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2013;21(1):16-21.
[48] PETRELLA RJ, PETRELLA M. A prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee. J Rheumatol. 2006;33(5):951-956.
[49] HEPPER CT, HALVORSON JJ, DUNCAN ST, et al. The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studies. J Am Acad Orthop Surg. 2009;17(10):638-646.
[50] TAMMACHOTE N, KANITNATE S, YAKUMPOR T, et al. Intra-Articular, Single-Shot Hylan G-F 20 Hyaluronic Acid Injection Compared with Corticosteroid in Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial. J Bone Joint Surg Am. 2016;98(11):885-892.
[51] DI MARTINO A, DI MATTEO B, PAPIO T, et al. Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial. Am J Sports Med. 2019; 47(2):347-354.
[52] JO CH, LEE YG, SHIN WH, et al. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem cells (Dayton, Ohio). 2014;32(5):1254-1266.
[53] LAMO-ESPINOSA JM, MORA G, BLANCO JF, et al. Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II). J Transl Med. 2016;14(1):246.
[54] FELSON DT. Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther. 2009;11(1):203.
[55] BANNURU RR, NATOV NS, DASI UR, et al. Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis--meta-analysis. Osteoarthritis Cartilage. 2011;19(6):611-619.
[56] HASHIZUME M, KOIKE N, YOSHIDA H, et al. High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis.Mod Rheumatol. 2010;20(5):432-438.
[57] PENA EDE L, SALA S, ROVIRA JC, et al. Elastoviscous substances with analgesic effects on joint pain reduce stretch-activated ion channel activity in vitro. Pain. 2002;99(3):501-508.
[58] NELSON FR, ZVIRBULIS RA, ZONCA B, et al. The effects of an oral preparation containing hyaluronic acid (Oralvisc(R)) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatol Int. 2015;35(1):43-52.
[59] ALTMAN R, BEDI A, MANJOO A, et al. Anti-Inflammatory Effects of Intra-Articular Hyaluronic Acid: A Systematic Review. Cartilage. 2019;10(1):43-52.
[60] FRIZZIERO L, GOVONI E, BACCHINI P. Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: clinical and morphological study. Clin Exp Rheumatol. 1998;16(4):441-449.
[61] GHOSH P, GUIDOLIN D. Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent? Semin Arthritis Rheum. 2002;32(1):10-37.
[62] LISIGNOLI G, GRASSI F, ZINI N, et al. Anti-Fas-induced apoptosis in chondrocytes reduced by hyaluronan: evidence for CD44 and CD54 (intercellular adhesion molecule 1) invovement. Arthritis and rheumatism. 2001;44(8):1800-1807.
[63] 杨俊龙,王艳娉,张源,等.透明质酸治疗膝骨关节炎相关机制的研究进展[J].中国疼痛医学杂志,2017,23(6):451-454.
[64] 张勤勤,谌亮,岑莲,等.透明质酸凝胶的制备及其在关节软骨再生中的应用[J].现代化工,2019,39(10):128-131.
[65] HE T, LI B, COLOMBANI T, et al. Hyaluronic acid-based shape-memory cryogel scaffolds for focal cartilage defect repair. Tissue Eng Part A. 2020 Oct 27.
[66] 赵峰,何薇,刘少俊,等.负载软骨细胞的透明质酸可注射材料修复软骨缺损[J].中国组织工程研究,2017,21(30):4787-4792.
[67] LIU MH, SUN JS, TSAI SW, et al. Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation. Nutr Res. 2010;30(1):57-65.
[68] 郝德峰,张鲁青,刘玉栋.低强度脉冲超声联合关节腔内注射玻璃酸钠修复关节软骨缺损[J].中国组织工程研究,2017,21(30):4775-4780.
[69] PARK YB, HA CW, KIM JA,et al. Single-stage cell-based cartilage repair in a rabbit model: cell tracking and in vivo chondrogenesis of human umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel composite. Osteoarthritis Cartilage. 2017;25(4):570-580.
[70] SUDHA PN, ROSE MH. Beneficial effects of hyaluronic acid. Adv Food Nutr Res. 2014;72:137-176.
[71] OHYA Y, TAKEDA S, SHIBATA Y, et al. Evaluation of polyanion-coated biodegradable polymeric micelles as drug delivery vehicles. J Control Release. 2011;155(1):104-110.
[72] ROSEN J, NIAZI F, DYSART S. Cost-Effectiveness of Treating Early to Moderate Stage Knee Osteoarthritis with Intra-articular Hyaluronic Acid Compared to Conservative Interventions. Adv Ther. 2020;37(1):344-352.
[73] TAMURA T, HIGUCHI Y, KITAMURA H, et al. Novel hyaluronic acid-methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models. Arthritis Res Ther. 2016;18:79.
[74] ISHIKAWA M, YOSHIOKA K, URANO K, et al. Biocompatibility of cross-linked hyaluronate (Gel-200) for the treatment of knee osteoarthritis. Osteoarthritis Cartilage. 2014;22(11):1902-1909.
[75] LO GH, LAVALLEY M, MCALINDON T, et al. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA. 2003;290(23):3115-3121.
|