中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (7): 1130-1136.doi: 10.12307/2022.156

• 干细胞综述 stem cell review • 上一篇    下一篇

肌源干细胞在周围神经再生中的潜力

安维政,何  萧,任  帅,刘建宇   

  1. 哈尔滨医科大学附属第二医院骨一科,黑龙江省哈尔滨市  150000
  • 收稿日期:2020-12-23 修回日期:2020-12-25 接受日期:2021-02-22 出版日期:2022-03-08 发布日期:2021-10-29
  • 通讯作者: 刘建宇,博士,主任医师,教授,哈尔滨医科大学附属第二医院骨一科,黑龙江省哈尔滨市 150000
  • 作者简介:安维政,男,1991年生,黑龙江省哈尔滨市人,汉族,在读硕士,主要从事组织工程方面的研究。
  • 基金资助:
    国家自然科学基金(81971828),项目负责人:刘建宇

Potential of muscle-derived stem cells in peripheral nerve regeneration

An Weizheng, He Xiao, Ren Shuai, Liu Jianyu   

  1. First Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China
  • Received:2020-12-23 Revised:2020-12-25 Accepted:2021-02-22 Online:2022-03-08 Published:2021-10-29
  • Contact: Liu Jianyu, MD, Chief physician, Professor, First Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China
  • About author:An Weizheng, Master candidate, First Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81971828 (to LJY)

摘要:

文题释义:
周围神经损伤:周围神经是指中枢神经(脑和脊髓)以外的神经。它包括12对脑神经、31对脊神经和自主神经(交感神经、副交感神经)。周围神经损伤主要是由于各种原因引起受该神经支配的区域出现感觉障碍、运动障碍。
组织工程:将细胞生物学和材料科学相结合,进行体外或体内构建组织或器官的新兴学科。从机体获取少量的活体组织在体外进行培养扩增,将扩增的细胞与具有生物相容性、可降解性生物材料(支架)按一定的比例混合,使细胞黏附在生物材料上;将该复合物植入机体的组织或器官病损部位,随着生物材料在体内逐渐被降解和吸收,植入的细胞在体内不断增殖并分泌细胞外基质,最终形成相应的组织或器官,从而达到修复创伤和重建功能的目的。
背景:肌源性干细胞具有强大的自我更新和多向分化潜能,在神经损伤修复领域具有广泛应用前景。
目的:文章就周围神经损伤的治疗现状和肌源干细胞治疗周围神经损伤的研究进展进行综述。
方法:以“肌源干细胞,周围神经损伤,组织工程,许旺细胞,移植,再生,神经导管”或“muscle-derived stem cell,peripheral nerve injury,tissue engineering,Schwann cells,transplant,regeneration,nerve conduit”为检索词,检索PubMed、CNKI、万方数据库,排除重复性研究以及内容不相关的文献,最后纳入100篇文献进行综述。
结果与结论:肌源干细胞通过分化为神经再生所需要的各种支持细胞和强大的旁分泌作用,在修复神经损伤等方面表现出良好的再生潜力。

https://orcid.org/0000-0003-4653-385X(安维政) 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

关键词: 肌源干细胞, 周围神经损伤, 许旺细胞, 移植, 神经导管, 再生, 神经营养因子, 组织工程, 分化, 综述

Abstract: BACKGROUND: Muscle-derived stem cells have strong self-renewal and multi-directional differentiation potential, which has a wide application prospect in the field of nerve injury repair.
OBJECTIVE: To review the treatment status of peripheral nerve injury and research progress of muscle-derived stem cells in the treatment of peripheral nerve injury. 
METHODS: “Muscle-derived stem cell, peripheral nerve injury, tissue engineering, Schwann cell, transplant, regeneration, nerve conduit” were the search words. The articles in PubMed, CNKI and Wanfang databases were cross-searched. After excluding repetitive research and irrelevant articles, 100 articles were finally included for review.  
RESULTS AND CONCLUSION: Muscle-derived stem cells show good regenerative potential in repairing nerve injury by differentiating into various kinds of support cells needed for nerve regeneration and powerful secretory function.

Key words: muscle-derived stem cells, peripheral nerve injury, Schwann cells, transplantation, nerve conduit, regeneration, neurotrophic factor, tissue engineering, differentiation, review

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