中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (4): 597-603.doi: 10.12307/2022.098
• 生物材料综述 biomaterial review • 上一篇 下一篇
康坤龙,王新涛
收稿日期:
2020-09-24
修回日期:
2020-09-28
接受日期:
2020-11-09
出版日期:
2022-02-08
发布日期:
2021-12-06
通讯作者:
王新涛,主任医师,教授,博士生导师,硕士生导师,哈尔滨医科大学附属第二医院骨科,黑龙江省哈尔滨市 150001
作者简介:
康坤龙,男,1994年生,陕西省渭南市人,汉族,哈尔滨医科大学在读硕士,主要从事骨组织工程研究。
基金资助:
Kang Kunlong, Wang Xintao
Received:
2020-09-24
Revised:
2020-09-28
Accepted:
2020-11-09
Online:
2022-02-08
Published:
2021-12-06
Contact:
Wang Xintao, Chief physician, Professor, Doctoral supervisor, Master’s supervisor, Department of Orthopedics, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
About author:
Kang Kunlong, Master candidate, Department of Orthopedics, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Supported by:
摘要:
文题释义:
生物支架材料:目前单一支架材料难以满足骨组织工程的成骨需要,生物支架材料研究将集中于通过不同的制造技术将生物支架材料进行复合,并添加生长因子及具有趋化作用的多肽,将骨组织工程3要素集成一体,制成具有最优良的成骨作用的生物支架。
骨髓间充质干细胞:是一种中胚层来源的多能干细胞,具有易获取、易培养、低免疫原性和易于外源基因转染并长期表达等特点,并具有优良的成骨分化能力,是目前骨组织工程应用最广泛的干细胞。
背景:目前单一生物支架材料难以满足骨组织工程的成骨需要,骨髓间充质干细胞具有优良的成骨特点,复合支架材料及复合生长因子的支架具有更优良的成骨能力,是目前研究的热点。
目的:对不同生物支架材料及其改型后促进骨髓间充质干细胞成骨分化进行综述。
方法:由第一作者通过检索中国知网、万方、维普、PubMed、Embase数据库 2014年1月至2020年7月发表的相关文献,检索词为“骨髓间充质干细胞,支架,成骨分化,羟基磷灰石,胶原,壳聚糖;Bone marrow mesenchymal stem cells,scaffold,osteogenic,hydroxyapatite,collagen,chitosan”,最终选取符合标准的文献69篇。
结果与结论:骨组织工程的飞速发展可有效解决骨缺损修复的难题,种子细胞和生物支架材料是骨组织工程的核心内容。骨髓间充质干细胞具有优良的成骨分化能力,被广泛应用于骨组织工程。将不同的支架材料复合,利用先进的制备工艺或者进行支架的表面修饰、添加生长因子等可充分结合各种生物支架材料的优点,诱导骨髓间充质干细胞的成骨分化和支架血管的形成,达到修复骨缺损的目的,是骨组织工程的研究热点。
https://orcid.org/0000-0002-6598-9660 (康坤龙)
中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程
中图分类号:
康坤龙, 王新涛. 生物支架材料促进骨髓间充质干细胞成骨分化的研究热点[J]. 中国组织工程研究, 2022, 26(4): 597-603.
Kang Kunlong, Wang Xintao. Research hotspot of biological scaffold materials promoting osteogenic differentiation of bone marrow mesenchymal stem cells[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(4): 597-603.
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1.3 数据提取 共检索到文献285篇, 其中中文文献95篇、英文文献190篇,排除与研究目的相关性差及内容陈旧、重复的文献,纳入69篇符合标准的文献进行综述,见图1。
1.4 质量评价 符合纳入标准的69篇文献中,文献[1]探讨了骨组织工程发展,文献[2-6]探讨了骨髓间充质干细胞的优点及骨组织工程对支架材料的条件,文献[7-32]探讨了无机材料及其改性促进骨髓间充质干细胞成骨分化的研究进展,文献[34-50]探讨了天然高分子材料及其改性促进骨髓间充质干细胞的研究进展,文献[51-58]探讨了改性合成高分子材料对促进骨髓间充质干细胞成骨分化的研究进展,文献[58-65]探讨了钛金属材料改性促进骨髓间充质干细胞成骨分化研究进展,文献[66-69]描写了支架特性对骨髓间充质干细胞成骨分化的影响。
文题释义:
生物支架材料:目前单一支架材料难以满足骨组织工程的成骨需要,生物支架材料研究将集中于通过不同的制造技术将生物支架材料进行复合,并添加生长因子及具有趋化作用的多肽,将骨组织工程3要素集成一体,制成具有最优良的成骨作用的生物支架。
骨髓间充质干细胞:是一种中胚层来源的多能干细胞,具有易获取、易培养、低免疫原性和易于外源基因转染并长期表达等特点,并具有优良的成骨分化能力,是目前骨组织工程应用最广泛的干细胞。
文章对于近年来生物支架材料改性后促进骨髓间充质干细胞成骨分化研究热点进行归纳综述,指出不同的类型的支架材料在材料特性、制作方式、空间结构、表面涂层、复合材料、生长因子等方面改性后使材料特性、成骨性、生物相容性、抗压强度和弹性模量以及降解率等不断改进,在更优良的促进骨髓间充质干细胞成骨分化的同时,满足骨组织工程飞速发展对生物支架材料的需求,并小结了当前生物支架材料的研究热点以及未来复合支架材料的研究方向。
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