中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (34): 5561-5569.doi: 10.12307/2021.255

• 生物材料综述 biomaterial review • 上一篇    下一篇

血管支架及其在动脉瘤治疗中的发展趋势

李  芳1,吴可通2,赵  珺3,李  刚1   

  1. 1苏州大学纺织与服装工程学院,现代丝绸国家工程实验室,江苏省苏州市   215123;2中山大学附属第六医院介入中心,广东省广州市   510655;3上海交通大学附属第六人民医院血管外科,上海市   200233
  • 收稿日期:2020-08-17 修回日期:2020-08-21 接受日期:2020-09-19 出版日期:2021-12-08 发布日期:2021-07-28
  • 通讯作者: 李刚,博士,教授,苏州大学纺织与服装工程学院,现代丝绸国家工程实验室,江苏省苏州市 215123
  • 作者简介:李芳,女,1996年生,陕西省渭南市人,汉族,在读硕士,主要从事医用纺织材料的研究
  • 基金资助:
    国家重点研发计划(2017YFC1103600),项目参与者:李刚;江苏省第十五批“六大人才高峰”高层次人才项目(GDZB-
    035),项目负责人:李刚;江苏省高层次创新创业人才引进计划“科技副总”项目(FZ20190257),项目负责人:李刚;南通市科技计划应用基础研究-工业项目(GY12017002),项目负责人:李刚

Advances of endovascular stent and its treatment for aneurysms

Li Fang1, Wu Ketong2, Zhao Jun3, Li Gang1   

  1. 1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, Jiangsu Province, China; 2Department of Interventional Therapy Center, Six Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Guangdong Province, China; 3Department of Vascular Surgery, Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
  • Received:2020-08-17 Revised:2020-08-21 Accepted:2020-09-19 Online:2021-12-08 Published:2021-07-28
  • Contact: Li Gang, MD, Professor, National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, Jiangsu Province, China
  • About author:Li Fang, Master candidate, National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, Jiangsu Province, China
  • Supported by:
    the National Key Research & Development Program, No. 2017YFC1103600 (to LG); the Fifteenth Batch of “Six Talent Peaks” High-Level Talent Project in Jiangsu Province, No. GDZB-035 (to LG); the “Vice President of Science and Technology” Project of Jiangsu Provincial High-Level Innovation and Entrepreneurship Talent Introduction, No. FZ20190257 (to LG); the Nantong Municipal Science and Technology Plan Applied Basic Research-Industrial Project, No. GY12017002 (to LG)

摘要:

文题释义:
血管支架:是一种内支架,在血管发生狭窄或病理性扩张时于病变段植入这种内支架,达到支撑血管、隔绝血液且保持管腔内血流通畅的目的。目前临床上所应用的支架种类众多,应根据人体的不同生理学解剖结构、不同种类疾病来选择不同类型的血管支架。
动脉瘤:是指动脉壁发生了病变或者损伤,形成了动脉壁局部性扩张或者膨出,当血管直径扩张到正常血管直径的1.5倍时可将其称为动脉瘤。根据所处位置不同,动脉瘤可分为腹主动脉瘤、胸主动脉瘤、颅内动脉瘤和内脏动脉瘤,动脉瘤一旦破裂,患者死亡率高达80%。
背景:随着血管疾病发病率的逐年上升,采用血管支架配合微创手术在血管疾病治疗中的临床应用越来越普遍。
目的:阐述血管支架的研究背景、性能要求、种类、原材料、制备和后加工技术,分析血管支架植入人体后所出现的并发症及改善方法。
方法:应用计算机检索中国知网、Web of Science数据库,检索时间期限为2005至2020年,中文检索关键词为“血管支架、动脉瘤、腔内隔绝术、研究现状”,英文检索关键词为“vascular stent;aneurysm;endovascular exclusion;research status”。
结果与结论:采用血管支架配合微创手术治疗动脉瘤具有重要的临床研究和应用价值,然而传统血管支架不能同时具备良好的远期畅通率、抗疲劳性、抗血栓和抗肿瘤功能,应该从结构设计、血管内皮化和高效药物缓释功能改性等方面进行系统设计和改进。血管支架研究是涉及多学科交叉的前沿研究,需要生物材料、工程技术和医学临床的多学科人才团队协同创新,才能开发出相容性更好、性能更稳定和价格更低的血管支架,为人类的医疗事业做贡献。
https://orcid.org/0000-0001-9343-282X (李芳) 

关键词: 材料, 支架, 血管支架, 动脉瘤, 研究现状, 内皮化, 抗血栓, 综述

Abstract: BACKGROUND: With the increasing incidence of vascular diseases, the clinical application of vascular stents combined with minimally invasive treatment surgery is widely used.
OBJECTIVE: To describe the research background, performance requirements, types, raw materials, production and modification techniques of endovascular stents, and analyze the complications and improvement methods after the endovascular stent implanted in the human body.
METHODS: The databases of CNKI and Web of Science were searched, and the search time period was from 2005 to 2020. The key words were “vascular stent, aneurysm, endovascular exclusion, research status” in English and Chinese. 
RESULTS AND CONCLUSION: The use of endovascular stents combined with minimally invasive treatment for aneurysms is very important in clinic. Traditional vascular stents cannot have good long-term patency rate, durability, anti-thrombosis and anti-tumor functions at the same time; it should be systematically designed and improved from the aspects of structural design, endothelialization, and functional modification of high effective drug release. The study of endovascular stents is a cutting-edge research involving multidisciplinary interdisciplinary research. To develop vascular stents with more biocompatible, more stable, and lower costs, the collaborative innovation of a multidisciplinary team of talents in biological materials, engineering technology and clinical medicine is important, so as to contribute to the medical cause of human beings.

Key words: materials, stents, vascular stents, aneurysms, research status, endothelialization, anti-thrombosis, review

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