中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (4): 612-612.doi: 10.3969/j.issn.2095-4344.0099

• 组织构建综述 tissue construction review • 上一篇    下一篇

代谢组学在关节炎领域的研究现状及文献计量学分析

张永怡1,孙志岭1,彭琳秀2,薛  莲1,焦文娟1,何  静1   

  1. 南京中医药大学,1护理学院,2药学院,江苏省南京市  210023
  • 收稿日期:2017-10-14 出版日期:2018-02-08 发布日期:2018-02-08
  • 通讯作者: 孙志岭,博士,教授,南京中医药大学护理学院,江苏省南京市 210023
  • 作者简介:张永怡,女,1993生,江苏省新沂市人,汉族,南京中医药大学在读研究生,主要从事中西医结合护理研究。
  • 基金资助:

    国家自然科学基金面上项目(81774383);江苏省普通高校学术学位研究生科研创新计划项目(KYLX16_1164);江苏省优势学科二期项目南京中医药大学护理学一级学科指令性课题(YSHL2016-016)

Research status of metabonomics in arthritis: a bibliometric analysis

Zhang Yong-yi1, Sun Zhi-ling1, Peng Lin-xiu2, Xue Lian1, Jiao Wen-juan1, He Jing1   

  1. 1College of Nursing, 2College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
  • Received:2017-10-14 Online:2018-02-08 Published:2018-02-08
  • Contact: Sun Zhi-ling, M.D., Professor, College of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
  • About author:Zhang Yong-yi, Studying for master’s degree, College of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
  • Supported by:

    the General Project of National Natural Science Foundation of China, No. 81774383; the Research Innovation Project for the Academic Postgraduates in Colleges of Jiangsu Province, No. KYLX16_1164; the Phase II Project of Dominant Disciplines of Jiangsu Province, Mandatory Project of Nursing of Nanjing University of Chinese Medicine, No. YSHL2016-016

摘要:

文章快速阅读:

文题释义:
非靶向代谢组学:在有限的研究和背景知识的基础上,对生物体内源性代谢物进行全面系统的、无偏向的代谢组学分析,从而找出差异代谢物。目前,非靶向代谢组学分析在疾病诊断与治疗机制研究等领域广泛应用,可以为疾病治疗机制或者疾病发病机制研究的瓶颈问题提供新的思路。
靶向代谢组学:针对特定的代谢物进行的有偏向的代谢组学分析。在非靶向代谢组学发现差异代谢物后,再进行靶向代谢组学进行系统的确证。

摘要
背景:
研究表明,关节炎的诊断与治疗机制研究可以从代谢组学的角度,进行代谢产物分析。代谢组学结合文献分析,可全面地了解其在骨关节炎领域的研究现状。
目的:基于文献计量学对代谢组学在关节炎的研究现状进行分析与总结,并对未来发展趋势进行展望。
方法:计算机检索中国知网、维普网、万方、中国生物医学数据库、PubMed、EBSCO、Web of Science、Elsevier数据库中有关代谢组学在关节炎领域研究的文献,检索时间为建库到2017年5月。中文检索词:(“代谢组学”OR“代谢组”)AND“关节炎”;英文检索词:“Metabolomics”AND “Arthritis”。 初步检索得到文献201篇,按照纳入和排除标准,最终纳入59篇进行文献进行基本信息与研究内容的分析。
结果与结论:①从2007年开始出现相关文献,文献数量逐年增加;②第一作者研究单位是高校、医院、研究院,发文量分别是37篇(63%)、15篇(25%)和7篇(12%);③收录期刊文献44篇(75%)、学位论文11篇(19%)、会议论文4篇(7%),44篇期刊文献收录在38种期刊杂志;④基金支持:36篇文献获得基金资助(61%)。国家自然科学基金资助的文献最多,共29篇(49%),厅局级基金18篇(31%),省部级基金10篇(17%),国外基金5篇(8%),校级项目5篇(8%);⑤关节炎类型:类风湿关节炎40篇(68%)、骨关节炎7篇(12%)、痛风性关节炎6篇(10%),其他类型6篇(10%);⑥文献研究方向:关节炎治疗机制研究30篇(51%),发病机制研究17篇(29%),关节炎中医症候研究6篇(10%),综述6篇(10%);⑦代谢组学检测样本:体液样本53篇(90%),组织样本6篇(10%);⑧代谢组学分析技术:液相色谱-质谱联用技术33篇(56%)、核磁共振15篇(25%)、气相色谱-质谱联用技术10篇(17%)、联合液相与气相色谱-质谱技术1篇(2%);⑨由此提示,代谢组学已经普遍应用到关节炎领域中,并成为研究热点。另外,基于代谢组学了解中医药治疗关节炎副作用代谢途径,可为中医药的前瞻性研究与临床合理使用中医药治疗关节炎提供科学参考。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0002-0574-6755(张永怡)

关键词: 代谢组学, 中医药疗法, 类风湿关节炎, 痛风性关节炎, 骨关节炎, 文献计量学, 综述, 国家自然科学基金面上项目

Abstract:

BACKGROUND: Mechanisms undelying diagnosis and treatment of arthritis can be analyzed by metabonomics to study the metabolites. The combination of metabonomics and bibliometrics can systematically clarify the research status of osteoarthritis.
OBJECTIVE: To analyze and summarize the research status of metabonimics in arthritis, and to prospect the future tendency.
METHODS: CNKI, VIP, WanFang, CBM, PubMed, EBSCO, Web of Science and Elsevier databases were searched for the articles addressing the metabonimics in arthritis published before May 2017. The keywords were “metabolomics and arthritis” in English and Chinese, respectively. Initially 201 articles were retrieved, and finally 59 articles were included based on the inclusion and exclusion criteria for basic information and result analysis.
RESULTS AND CONCLUSION: (1) Literature of metabonomics on arthritis began to be reported from 2007, and the number of literature increased with time. (2) The first author’s affiliations were concentrated in universities 37(63%), hospitals 15 (25%) and institutes 7 (12%). (3) The articles included 44 articles from journals (75%), 12 dissertation (19%), 4 conference papers (7%), and the 44 papers were published in 38 kinds of journals. (4) Totally 36 articles were funded, 29 articles (49%) funded by the National Natural Science Foundation, 18 (31%) funded by department-level foundation, 10 (17%) funded by provincial foundation, 5 (8%) foreign foundation and 5 (8%) funded by school foundation. (5) The types of arthritis were mainly rheumatoid arthritis 40 (68%), osteoarthritis 7 (12%), gouty arthritis 6 (10%) and others 6 (10%). (6) The main research directions were metabonomis on treatment effectiveness 30 (51%), pathogenesis of arthritis 17 (29%), Chinese medicine syndromes 6 (10%) and research progress 6 (10%). (7) Metabolomics samples in the literature included the body fluid samples 53 (90%) and tissue samples 6 (10%). (8) Metabonomics analysis techniques included liquid chromatography-mass spectrometry 33 (56%), nuclear magnetic resonance technology 15 (25%), gas chromatography-mass spectrometry 10 (17%), NMR combined with GC-MS 1 (2%). In summary, metabonomics has been extensively applied in arthritis and has been an issue of concern. Understanding the side events in Chinese medicines for arthritis based on metabonomics can provide reference for the following prospective study and clinical application.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Bibliometrics, Systems Biology, Arthritis, Tissue Engineering

中图分类号: