中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (1): 133-140.doi: 10.3969/j.issn.2095-4344.2148
• 干细胞综述 stem cell review • 上一篇 下一篇
于承浩1,张 益 2,戚 超 2,陈进利 2,高甲科 2,于腾波 2
收稿日期:
2020-03-27
修回日期:
2020-04-02
接受日期:
2020-05-09
出版日期:
2021-01-08
发布日期:
2020-11-20
通讯作者:
于腾波,博士,青岛大学附属医院,山东省青岛市 266000
作者简介:
于承浩,男,1995年生,山东省德州市人,青岛大学在读硕士,主要从事关节方面研究。
基金资助:
Yu Chenghao1, Zhang Yi2, Qi Chao2, Chen Jinli2, Gao Jiake2, Yu Tengbo2
Received:
2020-03-27
Revised:
2020-04-02
Accepted:
2020-05-09
Online:
2021-01-08
Published:
2020-11-20
Contact:
Yu Tengbo, MD, Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
About author:
Yu Chenghao, Master candidate, Qingdao University, Qingdao 266000, Shandong Province, China
Supported by:
摘要:
文题释义:
肌腱干细胞:是肌腱组织经消化后提取的具有自我更新及多向分化能力的细胞,不同于正常肌腱细胞,其表达干细胞标记物,近年来多项研究证明肌腱干细胞是组织移植治疗肌腱损伤的优势细胞。
富血小板血浆:是指全血通过梯度离心分层后得到的富含血小板的血浆部分,含有多种较丰富的生物活性因子,其血小板浓度为全血的3倍。
背景:肌腱干细胞存在于肌腱中,对于肌腱修复具有独特的功能,不同细胞因子对肌腱干细胞的增殖、分化功能具有不同影响;富血小板血浆是指全血通过梯度离心分层后得到的富含血小板的血浆部分,含有多种较丰富的细胞因子,有助于促使韧带和肌腱再生。
目的:探讨细胞因子和富血小板血浆对肌腱干细胞增殖、分化影响的最新进展。
方法:由第一作者以“tendon derived stem cells,tendon stem/progenitor cells,tendon stem cell,platelet-rich plasma,ligament injury”为英文关键词,以“肌腱干细胞,富血小板血浆,肌腱损伤”为中文关键词。检索 2007 至 2019 年期间收录在 PubMed、中国知网、万方等数据库中的文献,排除与文章研究目的无关及重复性的文献,纳入符合标准的 83篇文献进行综述。
结果与结论:肌腱干细胞是进行细胞移植治疗肌腱损伤的理想细胞,其增殖、分化受细胞因子影响,富血小板血浆包含大量细胞因子,具有刺激肌腱干细胞增殖、分化的功能,亦有成为细胞移植载体的潜力。探究细胞因子和富血小板血浆与肌腱干细胞增殖、分化的关系,将为肌腱干细胞的临床应用寻觅一条新途径。
https://orcid.org/0000-0001-5576-2975 (于承浩)
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
中图分类号:
于承浩, 张 益, 戚 超, 陈进利, 高甲科, 于腾波. 细胞因子和富血小板血浆对肌腱干细胞的影响[J]. 中国组织工程研究, 2021, 25(1): 133-140.
Yu Chenghao, Zhang Yi, Qi Chao, Chen Jinli, Gao Jiake, Yu Tengbo. Effect of cytokines and platelet-rich plasma on tendon derived stem cells[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(1): 133-140.
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文题释义:#br# 肌腱干细胞:是肌腱组织经消化后提取的具有自我更新及多向分化能力的细胞,不同于正常肌腱细胞,其表达干细胞标记物,近年来多项研究证明肌腱干细胞是组织移植治疗肌腱损伤的优势细胞。#br#
富血小板血浆:是指全血通过梯度离心分层后得到的富含血小板的血浆部分,含有多种较丰富的生物活性因子,其血小板浓度为全血的3倍。
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
肌腱干细胞具有分化为肌腱细胞、促进肌腱愈合的天然优势,各因素对肌腱干细胞的影响已相继展开探索,这些因素是未来动物实验的指引,也能够为临床应用提供帮助;同时,支持肌腱干细胞移植的最佳载体正在被寻找,细胞依附性、孔隙率、合适的降解时间、足够的抗拉伸强度都是需要考虑的问题。富血小板血浆中富含各类细胞因子,而各种细胞因子对肌腱干细胞具有协同或者相反的作用,富血小板血浆对于肌腱干细胞的影响仍不清晰,选择更适合的种类与浓度还需要进一步的探索。
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
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