中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (37): 5594-5601.doi: 10.3969/j.issn.2095-4344.2016.37.018

• 组织构建综述 tissue construction review • 上一篇    下一篇

细胞因子对骨骼肌细胞和胰岛β细胞的作用

李  靖，张  翔，王丽萍，石  磊，牟宇政，常茜茜   

  1. 忻州师范学院，山西省忻州市  034000
  • 收稿日期:2016-06-12 出版日期:2016-09-09 发布日期:2016-09-09
  • 通讯作者: 张翔，硕士，教授，忻州师范学院，山西省忻州市 034000
  • 作者简介:李靖，男，1993年生，山西省朔州市人，汉族，忻州师范学院体育系在读本科生。
  • 基金资助:

    山西省2014年大学生创业创新训练基金项目，课题名称：减肥物质结合运动减肥效用研究；山西省忻州师范学院重点建设学科专项课题项目(xk201403)

Effects of cytokines on skeletal muscle cells and pancreatic beta cells

Li Jing, Zhang Xiang, Wang Li-ping, Shi Lei, Mu Yu-zheng, Chang Qian-qian   

  1. Xinzhou Teachers University, Xinzhou 034000, Shanxi Province, China
  • Received:2016-06-12 Online:2016-09-09 Published:2016-09-09
  • Contact: Zhang Xiang, Master, Professor, Xinzhou Teachers University, Xinzhou 034000, Shanxi Province, China
  • About author:Li Jing, Xinzhou Teachers University, Xinzhou 034000, Shanxi Province, China
  • Supported by:

    the Shanxi Provincial Foundation for College Students Entrepreneurship Innovation Training in 2014; the Key Construction Disciplines Project of Xinzhou Teachers University in Shanxi Province, No. xk201403

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摘要：

文章快速阅读：

文题释义：
骨骼肌细胞：骨骼肌细胞为长纤维状，且多核，从静息肌原细胞获得，也称为卫星细胞，激活后具有增殖分化和成肌能力。骨骼肌细胞作为转运载体在葡萄糖摄取、储存和利用中起着重要作用。
脂肪细胞因子：能够调节机体能量代谢，包括瘦素、脂联素、抵抗素和内脂素。脂肪细胞因子可通过靶向作用于骨骼肌细胞，促进骨骼肌的葡萄糖吸收和葡萄糖的代谢。
摘要
背景：多种细胞因子对骨骼肌细胞的生长发育起重要作用，包括细胞因子、生长因子、炎性蛋白等。
目的：探讨多种细胞因子的生物学特性及其对骨骼肌细胞及胰岛β细胞的影响。
方法：以“细胞因子、脂联素、瘦素、内脂素、骨骼肌细胞和胰岛β细胞”为中文检索词，以“cytokine, adiponectin，leptin，visfatin，skeletal muscle cells，islet β cell”为英文检索词。在中国期刊全文数据库和PubMed数据库中检索2002至2015年的相关文章，共检索到文献253篇，排除重复和相似文献，最终纳入53篇进行分析。
结果与结论：脂联素是最近发现的一种脂肪特异性蛋白质，可促进骨骼肌细胞摄取、储存和利用葡萄糖，从而提高胰岛素敏感性。瘦素对肌卫星细胞有激活作用，可以促进骨骼肌成肌细胞的增殖，对骨骼肌细胞生长和发育有重要作用。内脂素是一种多效细胞因子，广泛存在于骨骼肌、肝脏、骨髓中，具有调节炎症反应和免疫功能的作用，促进骨骼肌的葡萄糖吸收和葡萄糖的代谢，对骨骼肌细胞应激反应和信号转导有重要作用。

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程
ORCID: 0000-0002-7899-0660(李靖)

关键词: 组织构建, 组织工程, 细胞因子, 骨骼肌, 细胞, 胰岛β细胞

Abstract:

BACKGROUND: A variety of cytokines such as cytokines, growth factors and inflammatory proteins play an important role in the development of skeletal muscle.
OBJECTIVE: To investigate the biological characteristics of a variety of cytokines and their effects on skeletal muscle cells and pancreatic β cells.
METHODS: Relevant articles published from 2002 to 2015 were retrieved in CNKI and PubMed databases using the English keywords “cytokines, adiponectin, leptin, visfatin, skeletal muscle cells, pancreatic β cells”. Initially 253 literatures were obtained, and finally 53 eligible literatures were included based on the exclusion criteria.
RESULTS AND CONCLUSION: As a fat-specific protein newly found, adiponectin can improve the insulin sensitivity by promoting glucose uptake, storage and utilization in skeletal muscle cells. The activation of muscle satellite cells and skeletal myoblast proliferation are both dependent on leptin, so leptin plays a vital role in the skeletal muscle cell growth and development. Visfatin, a pleiotropic cytokine, widely presents in the skeletal muscle, liver and bone marrow, and participates in the regulation of inflammation and immune function. Furthermore, visfatin contributes to glucose uptake and metabolism in the skeletal muscle, and makes considerable effects on the stress and signal transduction of skeletal muscle cells.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Cytokines, Myoblasts, Skeletal, Insulin, Tissue Engineering

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