中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (36): 6820-6826.doi: 10.3969/j.issn.2095-4344.2012.36.031

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞治疗骨关节病及脊髓损伤的研究现状

孙 琦，王灿斌，刘继春，汤善华   

  1. 解放军第一八四医院骨科，江西省鹰潭市 335000
  • 收稿日期:2012-02-21 修回日期:2012-08-30 出版日期:2012-09-02 发布日期:2012-09-02
  • 通讯作者: 汤善华，硕士，副主任医师，解放军第一八四医院骨科，江西省鹰潭市335000 mouse_1001@163.com
  • 作者简介:孙琦，男，1982年生，江西省丰城市人，汉族，主要从事骨外科学的研究。 690781415@qq.com

Bone marrow mesenchymal stem cells for treatment of bone and joint disease and spinal cord injury

Sun Qi, Wang Can-bin, Liu Ji-chun, Tang Shan-hua   

  1. Department of Orthopedics, the 184 Hospital of Chinese PLA, Yingtan 335000, Jiangxi Province, China
  • Received:2012-02-21 Revised:2012-08-30 Online:2012-09-02 Published:2012-09-02
  • Contact: Tang Shan-hua, Master, Associate chief physician, Department of Orthopedics, the 184 Hospital of Chinese PLA, Yingtan 335000, Jiangxi Province, China mouse_1001@163.com
  • About author:Sun Qi, Department of Orthopedics, the 184 Hospital of Chinese PLA, Yingtan 335000, Jiangxi Province, China 690781415@qq.com.

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408

被引次数

8

摘要：

背景：目前，骨髓间充质干细胞已应用于临床上治疗骨关节疾病及脊髓损伤，乃至中枢神经系统病变等。
目的：分析骨髓间充质干细胞在骨关节病及脊髓损伤应用的现状。
方法：检索SCI数据库2002/2011有关骨髓间充质干细胞治疗骨关节病及脊髓损伤的文献，检索词为“干细胞(stem cells)；骨髓间充质干细胞(bone mesenchymal stem cells, BMSCs)；骨细胞(osteocyte or bone cell)；软骨细胞(chondrocyte)；软骨缺损(cartilage defect)；关节软骨(articular cartilage)；组织工程(tissue engineering)；股骨头坏死(femoral head necrosis)；脊髓损伤(spinal cord injury, SCI)”，对骨髓间充质干细胞治疗骨关节病及脊髓损伤的临床文献进行分析。
结果与结论：近年来，随着骨髓间充质干细胞研究的深入，干细胞应用于临床治疗骨科疾病成为可能。骨髓间充质干细胞主要存在于骨髓中并保持干细胞的多项分化潜能，因其在一定条件下在体内外可分化为骨、软骨，加之细胞本身的特性，已经被应用于治疗如骨缺损、骨不连股骨头坏死等一些骨科常见病。由于骨髓间充质干细胞的特性，使其在除组织工程外，创伤修复、细胞替代治疗、支持造血、基因治疗等方面的应用前景也相当广阔。

关键词: 干细胞, 骨髓间充质干细胞, 骨细胞, 软骨细胞, 软骨缺损, 关节软骨, 组织工程, 股骨头坏死, 脊髓损伤, 文献计量

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells have been used to treat bone and joint disease and spinal cord injury as well as central nervous system lesions clinically.
OBJECTIVE: To analyze the clinical application of bone marrow mesenchymal stem cells in treatment of bone and joint disease and spinal cord injury.
METHODS: A retrieval was performed for the literature of bone marrow mesenchymal stem cells used for treatment of bone and joint disease and spinal cord injury, using key words “bone marrow mesenchymal stem cells, osteocyte or bone cell, chondrocyte, cartilage defect, articular cartilage, tissue engineering, femoral head necrosis, spinal cord injury” between 2002-01 and 2011-12 in Science Citation Index (SCI) database.
RESULTS AND CONCLUSION: In recent years, bone marrow mesenchymal stem cells have been used for clinical treatment of orthopedic diseases. Bone marrow mesenchymal stem cells exist in the bone marrow and maintain the differentiation potential of stem cells. Bone marrow mesenchymal stem cells can be differentiated into osteocytes and chondrocytes under certain in vivo conditions and have been applied for treatment of bone defects, femoral head necrosis and other orthopedic diseases. Bone marrow mesenchymal stem cells can be used for would healing, cell replacement therapy, hematopoiesis and gene therapy in addition to tissue engineering due to their characteristics.

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