中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (36): 6815-6819.doi: 10.3969/j.issn.2095-4344.2012.36.030

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞对脑胶质瘤的趋瘤效应

范存刚，张庆俊   

  1. 北京大学人民医院神经外科，北京市 100044
  • 收稿日期:2011-10-25 修回日期:2011-12-01 出版日期:2012-09-02 发布日期:2012-09-02
  • 通讯作者: 张庆俊，主任医师，教授，博士生导师，北京大学人民医院神经外科，北京市 100044 zhangqjhb@yahoo.com
  • 作者简介:范存刚★，男，1978年生，天津市人，汉族，2005年河北医科大学毕业，硕士，主治医师，主要从事干细胞移植治疗中枢神经系统疾病的研究。 fancungang@yahoo.com.cn

Tropism of bone marrow mesenchymal stem cells for glioma

Fan Cun-gang, Zhang Qing-jun   

  1. Department of Neurosurgery, People's Hospital of Peking University, Beijing 100044, China
  • Received:2011-10-25 Revised:2011-12-01 Online:2012-09-02 Published:2012-09-02
  • Contact: Zhang Qing-jun, Chief physician, Professor, Doctoral supervisor, Department of Neurosurgery, People's Hospital of Peking University, Beijing 100044, China zhangqjhb@yahoo.com
  • About author:Fan Cun-gang★, Master, Attending physician, Department of Neurosurgery, People's Hospital of Peking University, Beijing 100044, China fancungang@yahoo.com.cn

PDF

287

被引次数

4

摘要：

背景：骨髓间充质干细胞在体内、外均具有较强的向胶质瘤趋向性迁移的能力，可作为基因靶向胶质瘤治疗的理想载体。
目的：在复习相关文献的基础上，探讨骨髓间充质干细胞向脑胶质瘤定向迁移的机制。
方法：由第一作者对CNKI和PUBMED数据库进行检索，英文关键词为“mesenchymal stem cells，bone marrow，glioma”，中文检索词为“间充质干细胞，骨髓，胶质瘤”。共检索到51篇相关文献，根据入选标准最终剩余27篇文章进行归纳总结。
结果与结论：骨髓间充质干细胞对胶质瘤具有较强的趋化性迁移的能力，这与胶质瘤细胞分泌的某些细胞因子和骨髓间充质干细胞表面相应受体之间的相互作用有关。增强骨髓间充质干细胞表面相关受体的表达有助于增强其趋瘤效应，进而增强抗胶质瘤作用。

关键词: 骨髓间充质干细胞, 脑胶质瘤, 趋瘤效应, 定向迁移, 综述文献

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) display extensive tropism for glioma in vitro and in vivo, and may serve as a promising vector for gene-targeted glioma therapy.
OBJECTIVE: To investigate the mechanism of tumor-specific tropism of BMSCs towards glioma on the basis of analyzing related literatures.
METHODS: The first author retrieved CNKI database and PubMed database for concerning articles. The key words were “mesenchymal stem cells, bone marrow, glioma” in Chinese and English. A total of 51 articles were retrieved primarily by computer, and 27 articles were finally included for review according to inclusion criteria.
RESULTS AND CONCLUSION: BMSCs have a strong migratory capacity towards glioma, which is mediated by the interaction of cytokines secreted by glioma and the related receptors expressed by BMCSs. Increasing the expression of certain receptors in BMCSs may strengthen the migration capacity and antitumor effect.

中图分类号: