[1] Cai J, Zhang Y, Liu P, et al. Generation of tooth-like structures from inte gration-free human urine induced pluripotent stem cells. Cell Regen (Lond). 2013;2(1):6 [2] Obara N, Suzuki Y, Irie K, et al.Expression of planar cell polarity genes during mouse tooth development. Arch Oral Biol. 2017;83: 85-91.[3] Mu Y,Gudey SK,Landström M.Non-Smad signaling pathways.Cell Tissue Res.2012; 7: 11-20.[4] Kohei Miyazono, Shingo Maeda, TakeshiI mamura.BMP receptor signaling: Transcriptional targ ets, regulation of signals, and signaling cross-talk.2005; 6(3):251-263.[5] Wang XP,Suomalainen M,Jorgez CJ,et al.Follistatin regulates enamel pattern in mouse inci-sior by asymmetrically inhibiting BMP signaling and ameloblast differentiation.Dev Cell. 2004; 7(5):719-30.[6] Guobin Yang, uohua Yuan, Wenduo Ye et al. An Atypical Canonical Bone Morphogenetic Protein (BMP) Signaling Pathway Regulates Msh Homeobox 1(Msx1) Expression during Odontogenesis. J Biol Chem. 2014; 289(45):31492-31502. [7] Kriangkrai R,Iseki S,Eto K,et al.Dual odontogenic origins develop at the early stage of rat maxillary incisor development. Anat Embryol. 2006; 211(2):101-108. [8] Hu X,Wang Y,He F, et al. Noggin Is Required for Early Development of Murine Upper Incisors.J dent Res. 2012; 9(4): 394-400.[9] Jia S,Kwon HE,Lan Y,et al.BMP4-Msx1 signaling and Osr2 control tooth organo-genesis through antagonistic regulation ofsecreted Wnt antagonists.Dev Biol.2016;420(1):110-119.[10] Kwon HJ,Park EK,Jia S,et al.Deletion of Osr2 Partially Rescues Tooth Development i- n Runx2 Mutant Mice.J Dent Res.2015; 94(8):1113-1119.[11] Laurikkala J,Kassai Y,Pakkasjärvi L,et al.Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol.2004;264(1): 91-105.[12] Lee HK,Park JT,Cho YS,et al.Odontogenic ameloblasts- associated protein (ODAM), via phosphorylation by bonemorphogenetic protein receptor type IB (BMPR-IB), is implicated in ameloblast differentiation.J Cell Biochem.2012; 113(5):1754-1765.[13] Yang J,Hui TQ,Yang DM,et al.Bone morphogeneic protein 2-induced human dental pulp cell differentiation involves p38 mitogen activated protein kinase actiwated canonical wnt pathway. Int Journal Of Oral Science.2015; 7:95-102.[14] Rakian A, Yang WC, Gluhak-Heinrich J, et al.Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodont- ium.Int J Oral Sci.2013;5(2): 75-84.[15] Ta?l? PN, Ayd?n S, Yalvaç ME, et al.BMP 2 and BMP 7 Induce Odonto- And Osteogenesis of Human Tooth Germ Stem Cells. Appl Biochem Biotechnol.2014; 172:3016-3025.[16] Gao B, Zhou X, Zhou X, et al.BMP7 and EREG Contribute to the Inductive Pot-ential of Dental Mesenchyme. Science report.2015; 5: 9903[17] 徐冉,张宇,邢舰誉, 等.BMP7对三维条件下小鼠iPS细胞成骨能力的影响[J].口腔医学研究,2016,32(4) : 322-325.[18] Murashima-Suginami A,Takahashi K,Sakata T,et al.Enhanced BMP signa-ling results in supernumerary tooth formation in USAG-1 deficient mouse.Biochem Biophys Res Commun.2008;369: 1012-1016.[19] Duan P, Bonewald LF. The role of the wnt/β-catenin signaling pathway in formation and m-aintenance of bone and teeth.Int J Biochem Cell Biol.2016; 77:23-29. [20] Gordon MD,Nusse R.Wnt signaling: multiple pathways, multiple receptors, and multip-le transcription factors.J Biol Chem.2006; 281(32) : 22429-22433.[21] Peng L, Dong G, Xu P, et al.Expression of Wnt5a in tooth germs and the related signal tra- nsduction analysis. Arch Oral Biol. 2010; 55(2):108-114.[22] Ahn Y, Sims C, Murray MJ, et al.MurrayMultiple modes of Lrp4 function in modu- lation of Wnt/β-catenin signaling during tooth development. Development.2017; 144: 2824-2836.[23] Bovolenta P, Esteve P, Ruiz JM, et al. Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease.J Cell Sci.2008;121(6):737-746. [24] Alldredge A, Fuhrmann S. Loss of Axin2 Causes Ocular Defects During Mouse Eye Devel-opment. Invest Ophthalmol Vis Sci.2016; 57(13):5253-5262.[25] Chen J, Lan Y, Baek JA, et al.Wnt/beta-catenin signaling plays an es- sential role in activation of odontogenic mesenchyme during early tooth development.Dev Biol.2009;334(1) :174-185.[26] Nadiri A, Kuchler-Bopp S, Haikel Y.Immunolocalization of BMP-2/-4, 成FGF-4, and WN-T10b in the developing mouse first lower molar.J Histochem Cytochem.2004;52(1):103-112.[27] Yamashiro T,Zheng L,Shitaku Y,et al.Wnt10a regulates dentin sialophosphoprotein m-RNA expression and possibly links odontoblastdifferentiation and tooth morphogenesis. Differentiation.2007;75(5):452-462. [28] Peng L, Dong G, Xu P, et al. Expression of Wnt5a in tooth germs and the related signal tra- nsduction analysis. Archives of oral biology.2010; 55 : 108-114.[29] Lin M,Li L,Liu C,et al.Wnt5a regulates growth, patterning, and odontoblast differ-entiation of developing mouse tooth.Dev Dyn. 2011; 240(2):432-440.[30] Jingjing Li, Lemonia Chatzeli, Eleni Panousopoulou et al. Epithelial stratification and pla- code invagination are separable functions in early morphogenesis of the molar tooth. Development. 2016; 143: 670-681.[31] Aurrekoetxea M, Irastorza I, García-Gallastegui P, et al. Wnt/β- Catenin Re-gulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of odontogenesis. Front Cell Dev Biol. 2016; 4:25.[32] Kratochwil K, Galceran J, Tontsch S, et al.BMP4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1−/− mice. Genes Dev. 2002;16(24):3173-3185.[33] Fujimori S, Novak H,Weissenböck M,et al.Wnt/β-catenin signaling in the dental mesenc-hyme regulates incisor development by regulating BMP4.Dev Biol.2010; 348(1):97-106.[34] Thisse B, Thisse C.Functions and regulations of fibroblast growth factor sig-naling during embryonic development.Developmental Biology.2005;287(2):390-402.[35] 欧明明,黄晓峰,韩培彦.成纤维细胞生长因子与器官发育[J] .中国组织工程研究, 2011,15(15):488-492.[36] Kriangkrai R,Iseki S,Eto K,et al.Dual odontogenic origins develop at the early stage of rat maxillary incisor developmen.Anat Embryol (Berl).2006;211(2):101-108.[37] Shao M, Liu C, Song Y, et al.FGF8 signaling sustains progenitor status and multipotency of cranial neural crest-derived mesenchymal cells in vivo and in vitro. J Mol Cell Biol. 2015;7(5): 441-454.[38] Mammoto T, Mammoto A, Torisawa YS,et al. Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.Dev Cell.2011;21(4) : 758-769.[39] Tai YY, Chen RS, Lin Y, et al.FGF-9 accelerates epithelial invagination for ectodermal organogenesis in real time bioengineered organ manipulation.Cell Commun Signal.2012;10 : 34.[40] Klein OD, Lyons DB, Balooch G, et al.An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development.2008; 135(2) : 377-385.[41] Nadiri A, Kuchler-Bopp S, Haikel Y,et al.Immunolocalization of BMP-2/-4, FGF-4, and WNT10b in the Developing Mouse First Lower Molar. J Histochem Cytochem. 2004;52(1):103-112.[42] Mitsiadis TA, Graf D, Luder H, et al.BMPs and FGFs target Notch sig-nalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Develo pment.2010; 137(18) : 3025-3035.[43] Laurikkala J,Kassai Y,Pakkasjärvi L,et al.Identification of a secreted BMP antagonist,ecto-din, integrating BMP, FGF,and SHH signals from the tooth enamel knot.Dev Biol.2003;264(1): 91-105.[44] Yoshiko Y, Wang H, Minamizaki T, et al. Mineralized tissue cells are a principal source of FGF23 . Bone.2007;40(6): 1565-1573.[45] Onishi T, Umemura S, Shintani S, et al. Phex mutation causes overexpression of FGF23 in teeth. Arch Oral Biol.2008;53(2): 99-104.[46] Mitsiadis TA, Tucker AS, De Bari C, et al. A regulatory relation- ship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination. Dev Biol. 2008;320(1):39-48.[47] Naveau A, Zhang B, Meng B, et al.Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017;32(11):2219-2231.[48] Kettunen P, Laurikkala J, Itäranta P,et al. Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Dev Dyn.2000; 219(3):322-32.[49] Wang XP, Suomalainen M, Felszeghy S, et al.An Integrated Gene Reg-ulatory Network Controls Stem Cell Proliferation in Teeth. PLoS Biol.2007; 5(6) : e159.[50] 王苏平,吴晓君,闫旭,等. Sonic Hedgehog信号通路在胚胎发育及神经修复中的现状与进展[J].中国组织工程研究.2015,19(46): 7523-7528.[51] Khan M, Seppala M, Zoupa M, et al.Hedgehog pathway gene expre- ssion during early development of the molar tooth root in the mouse. Gene Expr Patterns. 2007;7(3):239-243.[52] Li J, Chatzeli L, Panousopoulou E, et al.Epithelial stratification and pla-code invagination are separable functions in early morphogenesis of the molar tooth.Development.2016;143: 670-681.[53] Ohazama A, Haycraft CJ, Seppala M, et al. Primary cilia regulate Shh ac- tivity in the control of molar tooth number. Development. 2009;136(6):897-903.[54] Cobourne MT, Sharpe PT. Making up the numbers: The molecular control of Mammalian dental formula. Semin Cell Dev Biol.2010; 21(3):314-324.[55] Takahashi S, Kawashima N, Sakamoto K, et al.Differentiation of an amelo-blast-lineage cell line (ALC) is induced by Sonic hedgehog signaling. Biochem Biophys Res Commun.2007; 353(2):405-411.[56] Fraser GJ,Graham A,Smith MM.Conserved deployment of genes during odontogenesis across osteichthyans.Proc Biol Sci.2004; 271(1555):2311-2317.[57] Li J, Feng J, Liu Y et al. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth.Dev Cell.2015;33(2):125-135.[58] Huang X, Xu X, Bringas P Jr,et al.Smad4-Shh-Nfic Signaling Cascade -Medi-ated Epithelial-Mesenchymal Interaction Is Crucial in Regulating Tooth Root Development.J Bone Miner Res.2010;25(5) : 1167-1178.[59] Cai J, Mutoh N, Shin JO, et al.Wnt5a plays a crucial role in determining tooth size during murine tooth development.Cell Tissue Res.2011;345(3):367-377. |