中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (18): 3241-3244.doi: 10.3969/j.issn.1673-8225.2012.18.003

• 肾移植 kidney transplantation • 上一篇    下一篇

托特罗定可有效降低肾移植后导尿管引起的膀胱刺激症状*☆

李金锋，丰贵文，王  跃，庞新路，尚文俊，刘  磊   

  1. 郑州大学第一附属医院肾移植科，河南省郑州市  450052
  • 收稿日期:2011-12-09 修回日期:2011-12-29 出版日期:2012-04-29 发布日期:2012-04-29
  • 通讯作者: 丰贵文，博士，副主任医师，郑州大学第一附属医院肾移植科，河南省郑州市 450052
  • 作者简介:李金锋☆，男，1980年生，河南省延津县人，汉族，2009年复旦大学毕业，博士，主治医师，主要从事肾移植的研究。
  • 基金资助:

    郑州大学第一附属医院青年基金资助项目(2011-QN010)。

Tolterodine effectively attenuates catheter related bladder discomfort in kidney transplantation patients*☆

Li Jin-feng, Feng Gui-wen, Wang Yue, Pang Xin-lu, Shang Wen-jun, Liu Lei   

  1. Department of Renal Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou  450052, Henan Province, China
  • Received:2011-12-09 Revised:2011-12-29 Online:2012-04-29 Published:2012-04-29
  • Contact: Feng Gui-wen, Doctor, Associate chief physician, Department of Renal Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China fengguiwen123@ 126.com
  • About author:Li Jin-feng☆, Doctor, Attending physician, Department of Renal Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China jinfenglis512@126. com
  • Supported by:

     the Youth Foundation of the First Affiliated Hospital of Zhenzhou University, No. 2011-QN010*

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摘要：

背景：肾移植后需要长期留置导尿管，易引起膀胱刺激症状。
目的：应用膀胱过度活动症评分表评价肾移植后留置导尿管引起的膀胱刺激症状，同时评价托特罗定降低膀胱刺激症状的有效性。
方法：研究纳入102例亲属活体肾移植受者，肾移植后留置尿管，分别给予托特罗定    4 mg/d或相同剂量的安慰剂。采用膀胱过度活动症评分表评价受者不同时间的膀胱刺激症状。
结果与结论：随着尿管留置时间的延长，肾移植患者尿频及急迫性尿失禁的发生频率及程度逐渐增加。应用托特罗定后，患者尿频及急迫性尿失禁的发生频率及程度明显下降。说明肾移植后常规应用托特罗定可有效降低患者的膀胱刺激症状。
 

关键词: 膀胱刺激症状, 肾移植, 托特罗定, 尿管留置

Abstract:

BACKGROUND: Renal transplantation requires long term use of indwelling catheter, which could easily cause bladder irritation.
OBJECTIVE: To assess the catheter related bladder discomfort using Overactive Bladder Symptom Score in kidney transplantation patients; to evaluate the efficiency of tolterodine in preventing catheter related bladder discomfort in kidney transplantation patients.
METHODS: A total of 102 living-related kidney transplant recipients were involved in this study. Indwelling catheters were used after transplant; and patients were treated with 4 mg/d tolterodine or the same dose of placebo, respectively. The recipient bladder discomfort was assessed using Overactive Bladder Symptom Score at different time points.
RESULTS AND CONCLUSION: The incidence and severity of urgency and urgency incontinence increased in kidney transplant patients with increasing catheter indwelling time. With the application of tolterodine, the incidence and severity of urgency and urgency incontinence decreased significantly. These findings indicate that regulated application of tolterodine may effectively prevent catheter related bladder discomfort in kidney transplantation patients.

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