中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (52): 9813-9816.doi: 10.3969/j.issn.1673-8225.2011.52.028

• 骨与关节损伤基础实验 basic experiments of bone and joint injury • 上一篇    下一篇

糖尿病大鼠股骨头血管内皮功能障碍的变化

郑玉涛1，陈海英1，刘文革2，张鹏飞3   

  1. 1莆田学院医学院基础医学部，福建省莆田市 351100
    2福建医科大学附属协和医院骨科，福建省福州市 350003
    3福建医科大学病理学系，福建省福州市 350003
  • 收稿日期:2011-10-18 修回日期:2011-11-11 出版日期:2011-12-24 发布日期:2011-12-24
  • 作者简介:郑玉涛，男，1956年生，汉族，福建省莆田市人，副教授，主要从事临床应用解剖学教学和研究。 zheng_yu_tao@163.com
  • 基金资助:

    福建省教育厅A类科技项目(JA08189)，糖尿病大鼠微血管变化对股骨头结构的影响。

Variations of vascular endothelial dysfunction of the femoral head in diabetic rats

Zheng Yu-tao1, Chen Hai-ying1, Liu Wen-ge2, Zhang Peng-fei3   

  1. 1Department of Basic Medicine, Medical College of Putian University, Putian  351100, Fujian Province, China
    2Department of Orthopedics, Affiliated Union Hospital of Fujian Medical University, Fuzhou  350003, Fujian Province, China
    3Department of Pathology, Fujian Medical University, Fuzhou  350003, Fujian Province, China
  • Received:2011-10-18 Revised:2011-11-11 Online:2011-12-24 Published:2011-12-24
  • About author:Zheng Yu-tao, Associate professor, Department of Basic Medicine, Medical College of Putian University, Putian 351100, Fujian Province, China zheng_yu_tao@163.com
  • Supported by:

    Class A Science and Technology Foundation of Fujian Educational Department, No. JA08189*

PDF

314

被引次数

3

摘要：

背景：糖尿病骨病的并发症起病复杂，骨组织血管内皮病变可能是造成的一个重要原因。
目的：探讨糖尿病对大鼠股骨头内皮功能障碍的影响。
方法：将60只大鼠随机等分为对照组和糖尿病组，糖尿病组大鼠腹腔注射链脲佐菌素建立糖尿病模型。
结果与结论：造模15周时，与对照组相比，糖尿病组大鼠股骨头出现骨质疏松显微结构改变，血清一氧化氮水平明显降低，血浆内皮素1水平明显升高，糖尿病组股骨头凝血因子Ⅷ表达明显减少(P < 0.01)，提示糖尿病前期就出现内皮功能障碍。微血管增生，糖尿病诱发内皮功能障碍及相互作用与大鼠股骨头功能减退有关。

关键词: 糖尿病, 股骨头, 内皮素, 一氧化氮, 凝血因子Ⅷ, 内皮功能障碍

Abstract:

BACKGROUND: Onset reason of the complications of diabetic osteopathia is complicated. Endothelial lesions of blood vessel in bone tissue may play an important role in onset reason.
OBJECTIVE: To investigate the effects of diabetes on endothelial dysfunction of the femoral head in the rats.
METHODS: Totally 60 rats were randomly divided into diabetic group and control group. Diabetic model was constructed by intraperitoneal injection of streptozotocin in the diabetic group.
RESULTS AND CONCLUSION: Compared with the control group at 15 weeks after modeling, microstructure of the femoral head in the rats was changed, serum levels of nitric oxide level was significantly decreased, plasma endothelin 1 was significantly increased and expression of blood coagulation factorⅧ was significantly decreased in the diabetic group (P < 0.01). It is indicated that the endothelial dysfunction occurs in the prediabetes. Endothelial dysfunction is induced by micrangium accrementition and diabetes, which are related with the hypofunction of the femoral head in the rats.

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