中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (52): 9709-9712.doi: 10.3969/j.issn.1673-8225.2011.52.004

• 骨科植入物 orthopedic implant • 上一篇    下一篇

2 Hz极低频脉冲电磁场可促进金属植入物内固定四肢新鲜骨折的愈合

刘纪涛，陶  军   

  1. 南昌大学第三附属医院骨一科，江西省南昌市330008
  • 收稿日期:2011-07-05 修回日期:2011-10-18 出版日期:2011-12-24 发布日期:2011-12-24
  • 通讯作者: 陶军，副教授，副主任医师，硕士生导师，南昌大学第三附属医院骨一科，江西省南昌市330008 taojun125@sohu.com
  • 作者简介:刘纪涛★，男，1980年生，陕西省汉中市人，南昌大学医学院在读硕士，医师，主要从事骨与关节创伤方面的研究。 bluceliu123@163.com
  • 基金资助:

    课题受2009~2010年度江西省卫生厅科技计划项目(20093164)资助。

A 2 Hz extremely low-frequency pulsed magnetic field promotes the healing of fresh limb fractures following metallic implants internal fixation

Liu Ji-tao, Tao Jun   

  1. First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang  330008, Jiangxi Province, China
  • Received:2011-07-05 Revised:2011-10-18 Online:2011-12-24 Published:2011-12-24
  • Contact: Tao jun, Associate professor, Associate chief physician, Master’s supervisor, First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China taojun125@sohu.com
  • About author:Liu ji-tao★, Studying for master’s degree, Physician, First Department of Orthopaedics, Third Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China bluceliu123@163.com
  • Supported by:

    Technology Program of Health Department of Jiangxi Province in 2009-2010, No. 20093164*

PDF

342

被引次数

13

摘要：

背景：骨折内固定后易发生骨延迟愈合及骨不愈合。
目的：观察金属植入物骨折内固定后联合不同极低频率脉冲电磁场治疗四肢新鲜骨折的疗效。
方法：将四肢新鲜骨折患者随机分为4组，对照组内固定后给予常规治疗，其他3组内固定后第3天起分别配合2，16，32 Hz脉冲电磁场治疗，4组患者分别于内固定后4，8，12周行骨折部位的X射线检查，固定前及固定后联合脉冲电磁场治疗完成时，分别检测4组患者骨钙素、骨特异性碱性磷酸酶水平及Ⅰ型前胶原羧基末端前肽，并进行疗效评定。
结果与结论：随治疗时间延长，4组骨痂生成均增多(P < 0.01)；在相同时间点上，2，16，32 Hz治疗组骨痂生成情况及骨代谢生化指标均明显高于对照组(P < 0.01)；2 Hz治疗组骨痂生成情况及骨代谢生化指标均高于16，32 Hz治疗组(P < 0.05)。结果证实，脉冲电磁场促进骨痂生长从而促进骨折愈合，2 Hz极低频脉冲电磁场促进金属植入物内固定骨折愈合的疗效优于16，32 Hz。

关键词: 脉冲电磁场, 骨折, 愈合, 疗效, 金属植入物, 骨组织工程

Abstract:

BACKGROUND: Delayed bone healing and nonunion are prone to occur after fracture treated with internal fixation.
OBJECTIVE: To study the clinical effects of the pulsed magnetic fields (PEMFs) of different extremely low-frequency for treatment of fresh fracture of limbs after internal fixation with metallic implants.
METHODS: The patients with fresh fractures of the limbs were divided into four groups randomly. The patients of control group were treated with routine therapy and the patients of treatment group were treated with PEMFs of 2 Hz, 16 Hz and 32 Hz at 3 days after fixation. X-ray was performed at 4, 8, 12 weeks after fixation in all patients. The osteocalcin, bone-specific alkaline phosphatase and the carboxy-terminal propeptide of type Ⅰ procollagen were detected before and after fixation followed PEMFs to evaluate the effects of PEMFs on fracture.
RESULTS AND CONCLUSION: The callus formation of four groups were significantly higher than before as time going on (P <  0.01). The callus formation and biochemical indexes of bone metabolism of PEMFs groups of 2 Hz, 16 Hz and 32 Hz were significantly higher than that of the control group at the same time point (P < 0. 01), and the callus formation and biochemical indexes of bone metabolism of PEMFs group of 2 Hz were higher than those of the 16 Hz and 32 Hz (P < 0. 05). It is confirmed that PEMFs can promote the growth of callus to accelerate the healing process of bone fracture, and the effective of the extremely low-frequency PEMFs of 2 Hz is better than that of 16 Hz and 32 Hz.

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