中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (15): 2777-2780.doi: 10.3969/j.issn.1673-8225.2011.15.028

• 组织构建与中医药 tissue construction and traditional Chinese medicine • 上一篇    下一篇

补气活血类中药黄酮与锌协同的抗自由基作用

董顺福，徐  冲，韩  林   

  1. 吉林医药学院，吉林省吉林市，132013
  • 收稿日期:2010-10-12 修回日期:2010-11-22 出版日期:2011-04-09 发布日期:2013-11-06
  • 通讯作者: 董顺福，吉林医药学院，吉林省吉林市，132013 dsf20032008@ yahoo.com.cn
  • 作者简介:董顺福，男，1963年生，吉林省吉林市人，汉族，1984年东北师范大学毕业，教授，主要从事化学光谱分析及中药有效成分研究。
  • 基金资助:

    吉林省中医药管理局科研基金资助(08sys-118)。

Anti-free radical effects of flavone, invigorating qi and promoting blood circulations, synergized with zinc

Dong Shun-fu, Xu Chong, Han Lin   

  1. Jilin Medical College, Jilin  132013, Jilin Province, China
  • Received:2010-10-12 Revised:2010-11-22 Online:2011-04-09 Published:2013-11-06
  • Contact: Dong Shun-fu, Professor, Jilin Medical College, Jilin 132013, Jilin Province, China dsf20032008@ yahoo.com.cn
  • About author:Dong Shun-fu, Professor, Jilin Medical College, Jilin 132013, Jilin Province, China dsf20032008@ yahoo.com.cn
  • Supported by:

    the Administration of Traditional Chinese Medicine of Jilin Province, No. 08sys-118*

PDF

514

被引次数

16

摘要：

背景：药物总黄酮的含量与药物的种类有密切的关系，将提取中药中黄酮与微量元素结合，研究药物抗自由基效果，是研究中药药效机制的有效方法。
目的：观察补气活血类16种中药黄酮的含量、抗氧化作用，以及与微量元素锌协同作用抗自由基的效果。
方法：采用醇提法提取丹参等补气活血类16种中药中的总黄酮，紫外分光光度法测定药物总黄酮的含量，测定不同中药黄酮与锌作用抗氧化率。
结果与结论：不同补气活血类中药的总黄酮含量有一定差异，含量依次为是丹参>虎杖>赤芍>泽兰>充玉子>白芍>银杏叶>川芎>牛膝>当归>坤草>回心草>党参>黄芪>人参>郁金，但不同中药黄酮均能够抑制超氧阴离子自由基。与微量金属锌协同作用后，多数中药对超氧阴离子自由基的清除率增加，特别是人参黄铜的抗氧化能力提高效率达7倍，说明补气活血类药物作用可能与金属锌协同相关。

关键词: 总黄酮, 锌, 中药, 抗自由基, 协同作用, 紫外分光光度法

Abstract:

BACKGROUND: Contents of total flavonoids are closely related to species. It is an effective method to research pharmacodynamic mechanism of traditional Chinese medicine by combining Chinese medicine flavone with minor element for anti-free radical.
OBJECTIVE: To study the content and antioxidation of flavone in 16 kinds of Chinese medicine, and to explore the effects of flavone synergized with zinc on anti-free radical. 
METHODS: The contents of total flavones in 16 kinds of traditional Chinese medicine were extracted using alcohol extraction and measured by UV. The oxidation resistance effect of total flavone synergized with zinc on anti-free radical was determined.
RESULTS AND CONCLLUSION: There were certain variation of total flavones contents in different kinds of invigorating qi and promoting blood circulation traditional Chinese medicine, the contents as follows: salvia miltiorrhiza > giant knotweed > red peony root > trumpetweed > sufficient jade > white peony root > ginkgo leaf > ligusticum chuanxiong hort > achyranthes root > Chinese angelica > motherwort > rhodobryum roseum > codonopsis pilosula > milkvetch root > ginseng > curcuma longa L., but all the Chinese medicine could suppress superoxide anion radical. Most of traditional Chinese medicine increased the effect of oxidation resistance after zinc synergism, especially ginseng flavones, which increased 7-fold. The results demonstrated that the drug action of invigorating qi and promoting blood circulation traditional Chinese medicine may relates to zinc synergism.

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