中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (44): 8273-8276.doi: 10.3969/j.issn.1673-8225.2010.44.026

• 器官移植临床实践 clinical practice of organ transplantation • 上一篇    下一篇

单中心2年亲属活体肾移植受者69例优势分析

王  强1，李晓利2，蔡  明1，石炳毅1，钱叶勇1，李州利1，许  亮1   

  1. 解放军第三○九医院，1泌尿一科，2高干病房，北京市 100091
  • 出版日期:2010-10-29 发布日期:2010-10-29
  • 通讯作者: 蔡明，博士，主任医师，硕士生导师，解放军第三○九医院泌尿一科，北京市 100091 caiming@medmail.com.cn
  • 作者简介:王强★，男，1972年生，山西省离石市人，汉族，2005年解放军军医进修学院毕业，硕士，副主任医师，主要从事器官移植方面的研究。 wq301135@yahoo.com.cn

Superiority analysis of 69 living-related renal transplant recipients in a single center within 2 years

Wang Qiang1, Li Xiao-li2, Cai Ming1, Shi Bing-yi1, Qian Ye-yong1, Li Zhou-li1, Xu Liang1   

  1. 1 First Department of Urology, 2 Department of Cadre Ward, the 309 Hospital of Chinese PLA, Beijing  100091, China
  • Online:2010-10-29 Published:2010-10-29
  • Contact: Cai Ming, Doctor, Chief physician, Master’s supervisor, First Department of Urology, the 309 Hospital of Chinese PLA, Beijing 100091, China caiming@medmail.com.cn
  • About author:Wang Qiang★, Master, Associate chief physician, First Department of Urology, the 309 Hospital of Chinese PLA, Beijing 100091, China wq301135@yahoo.com.cn

PDF

366

被引次数

2

摘要：

背景：国内活体肾移植处于起步阶段，尚缺乏大宗样本的临床资料，为此国内移植专家达成了中国活体供肾移植博鳌会议共识，使活体肾脏移植规范化。
目的：回顾性分析单中心亲属活体肾移植受者的临床资料。
方法：2006-01/2008-03解放军第三○九医院全军器官移植中心收治的69例亲属肾移植受者，其中父母捐赠给孩子39例，孩子捐赠给父母1例，兄弟姐妹间捐赠19例，三代旁系血清7例，夫妻间捐赠3例；ABO血型相同66例，相容3例；HLA无错配5例，2位点错配者31例，1位点错配者32例，4位点错配者1例；取供者左肾66例，取供者右肾3例，均经开放手术取肾。术后采用环孢素/他克莫司+霉酚酸酯/硫唑嘌呤+泼尼松预防排斥反应。
结果与结论：69例受者中，均未发生移植肾失功，1年肾存活率达100%；平均热缺血时间为(3.56±1.42) min，平均冷缺血时间为(45.12±25.34) min，术后肾功能恢复正常时间为(5.6±7.0) d。肾移植后3个月内出现排斥反应9例，肺部感染2例，肾功能延迟恢复3例，肾动脉狭窄1例，骨髓抑制2例，脑梗死1例，尿瘘1例。提示随着活体肾移植供体严格、全面的评估，活体供肾移植具有并发症少、恢复快、排斥发生率低等优势，是目前尿毒症患者家庭自救的主要方式之一。

关键词: 活体肾移植, 亲属, 受者, 尿毒症, 并发症, 器官移植

Abstract:

BACKGROUND: Living-related renal transplantation is still at the beginning stage in China, and the large sample clinical data are insufficient. Thus, Boao consensus was achieved for the normalization of living-related renal transplantation.
OBJECTIVE: To retrospectively analyze the clinical experience of living-related renal transplant recipients in a single center.
METHODS: Totally 69 living-related renal transplant recipients at the Organ Transplantation Center, 309 Hospital of Chinese PLA, between January 2006 and March 2008, were retrospectively analyzed, 39 cases were parents donation to the children; 1 was children donation to parents; 19 were sibling donation; 7 cases were three generations of collateral serum; 3 cases of donation happened between husband and wife. 66 cases had the same ABO blood group, 3 cases of which were compatible; there are 5 cases with HLA mismatch, 31 cases of mismatch in 2 points, 32 in one point and 1 in 4 points; 66 persons were admitted for the left kidney and 3 persons for right kidney; 69 cases were all admitted for kidney through open surgery. Rejection was prevented by the use of cyclosporine / Prograf+ Mycophenolate Mofetil / azathioprine + Prednisone.
RESULTS AND CONCLUSION: Of 69 living-related renal transplant recipients, none had renal failure after transplantation, and the 1-year survival rate was 100%. The average warm ischemia time was (3.56±1.42) minutes and the average cold ischemia time was (45.12±25.34) minutes: the time when postoperative renal function returned to normal level was (5.6±7.0) days. 9 cases showed rejection at 3 months after surgery, 2 cases showed pulmonary infection, 3 cases had delayed graft function, 1 case got renal artery stenosis, 2 cases with bone marrow suppression, 1with brain root block, and 1 case with urinary fistula. With the rigorous and comprehensive assessment of living renal transplantation, living kidney transplantation has advantages of few complications, fast recovery and low incidence of rejection, is one of the main ways uremic patients take home self-help.

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