中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (31): 5713-5716.doi: 10.3969/j.issn.1673-8225.2010.31.004

• 肾移植 kidney transplantation • 上一篇    下一篇

肾移植前透析时间对移植后眼部并发症的影响

张  荻1，尚文俊2，丰贵文2，王丽娅1   

  1. 1 河南省眼科研究所，河南省郑州市  450003；2 郑州大学第一附属医院肾移植科，河南省郑州市 450052
  • 出版日期:2010-07-30 发布日期:2010-07-30
  • 通讯作者: 尚文俊，主治医师，郑州大学第一附属医院肾移植科，河南省郑州市 450052 shangwj111@163.com
  • 作者简介:张 荻☆，女，1979年生，河南省郑州市人，汉族， 2008年中南大学湘雅医学院毕业，博士，主治医师，主要从事斜视与小儿眼科方面的研究。 reedzhang79@yahoo.com.cn

Effect of preoperative dialysis time on ocular complications in renal transplant recipients

Zhang Di1, Shang Wen-jun2, Feng Gui-wen2, Wang Li-ya1   

  1. 1 Henan Eye Institute, Zhengzhou  450003, Henan Province, China; 2 Department of Kidney Transplantation, First Affiliated Hospital of Zhengzhou University, Zhengzhou  450052, Henan Province, China
  • Online:2010-07-30 Published:2010-07-30
  • Contact: Shang Wen-jun, Attending physician, Department of Kidney Transplantation, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China shangwj111@163.com
  • About author:Zhang Di☆, Doctor, Attending physician, Henan Eye Institute, Zhengzhou 450003, Henan Province, China reedzhang79@yahoo.com.cn

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被引次数

1

摘要：

背景：肾移植后眼部并发症主要与年龄、引起肾功能衰竭的原发病、体内毒性物质的长期累积及激素和免疫抑制剂的长期应用有关。肾移植前透析时间对移植后某些眼部并发症是否有影响有待验证。
目的：探讨肾移植前透析时间对移植后眼部并发症的影响。 
方法：选择159例肾移植后门诊随访患者，男108例，女51例，年龄(40.3±8.7)岁；肾移植时间为(3.8±2.1)年，肾移植前透析时间为(2.7±1.9)年；尸体肾移植81例，亲属肾移植78例。调查108例眼部并发症情况，对肾移植前不同透析时间移植后眼部并发症的发生率进行卡方检验及卡方线性趋势检验。 
结果与结论：159例肾移植患者中，83例(52.2%)患者至少存在一处眼部并发症，余下的76例(47.8%)患者眼部检查未发现明显异常，最常见的眼部并发症为睑裂斑/结膜变性，构成比为33.3%；其次为白内障，构成比为26.3%，主要表现为晶状体后极部后囊下出现灰白色颗粒状、斑块状混浊，可见空泡和水隙。4例(3.5%)青光眼患者经房角镜检查前房角均为开角，视野检查发现旁中心暗点1例，弓形暗点2例，鼻侧阶梯1例。结果显示肾移植前透析时间与移植后青光眼的发生有关，透析时间越久青光眼的发生率越高。

关键词: 血液透析, 眼, 肾移植, 并发症, 器官移植

Abstract:

BACKGROUND: The ocular complications in renal transplant recipients are concerned with the age, primary diseases, accumulation of the toxic substances in vivo and long-term application of the immune depressant. It is to be authenticated the effect of preoperative dialysis time on ocular complications in renal transplant recipients.
OBJECTIVE: To study the effect of preoperative dialysis time on ocular complications in renal transplant recipients.
METHODS: Clinical data of 159 patients underwent renal transplantation were analyzed, including 108 male and 51 female, aged (40.3±8.7) years. The duration of renal transplantation was (3.8±2.1) years, and the time of preoperative dialysis was (2.7±1.9) years. There were 81 patients with cadaveric renal transplantation and 78 patients with living related renal transplantation. The relationship between the preoperative dialysis time and ocular complications after renal transplantation was investigated by chi-square criterion. 
RESULTS AND CONCLUSIONS: There were 83 patients (52.2%) who had at least one ocular complication. There was no obvious abnormality in the rest 76 patients (47.8%). The most frequent ocular complication was pinguecula and conjunctival degeneration (33.3%), subsequent to catatact (26.3%), which showed a posterior capsule opacification. Four patients (3.5%) with glaucoma were open angle glaucoma. The examination of visual field showed paracentral scotoma for 1 patient, arcuate scotoma for 2 patients and nasal step for 1 patient. Preoperative dialysis time had a significant effect on the incidence of glaucoma in renal transplant recipients, the longer dialysis time results in high incidence rate.

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