中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (20): 5295-5303.doi: 10.12307/2026.742

• 生物材料综述 biomaterial review • 上一篇    下一篇

中药有效成分结合水凝胶修复骨缺损：成功与挑战

徐亚伟1，孟世龙1，张  徐1，汪成杰1，袁一峰2，史晓林2，王  娇3，刘  康2   

  1. 1浙江中医药大学第二临床医学院，浙江省杭州市  310053；2浙江中医药大学附属第二医院，浙江省杭州市  310005；3浙江省人民医院(杭州医学院附属人民医院)，浙江省杭州市  310014
  • 接受日期:2025-07-11 出版日期:2026-07-18 发布日期:2025-12-02
  • 通讯作者: 刘康，博士，副教授，主任中医师，博士生导师，浙江中医药大学附属第二医院，浙江省杭州市 310005
  • 作者简介:徐亚伟，男，2001年生，浙江省温州市人，汉族，浙江中医药大学在读硕士，主要从事中西医结合防治骨代谢疾病研究。
  • 基金资助:
    国家自然科学基金项目(82274272)，项目负责人：刘康；浙江中医药大学校级科研重点支撑项目(2025JKZDZC10)，项目负责人：刘康

Repairing bone defects with active ingredients of traditional Chinese medicine combined with hydrogels: successes and challenges

Xu Yawei1, Meng Shilong1, Zhang Xu1, Wang Chengjie1, Yuan Yifeng2, Shi Xiaolin2, Wang Jiao3, Liu Kang2     

  1. 1The Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China; 2The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China; 3Zhejiang Provincial People’s Hospital (People’s Hospital of Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, China
  • Accepted:2025-07-11 Online:2026-07-18 Published:2025-12-02
  • Contact: Liu Kang, MD, Associate professor, Chief physician, Doctoral supervisor, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
  • About author:Xu Yawei, Master candidate, The Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 82274272 (to LK); Key Scientific Research Support Project of Zhejiang Chinese Medical University, No. 2025JKZDZC10 (to LK)

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摘要：

文题释义：
水凝胶：由亲水性高分子通过物理或化学交联形成的一种三维网络结构材料，能够吸收并保持大量水分而不溶解。水凝胶在骨组织工程中通过模拟骨微环境、递送活性成分等功能实现骨缺损的高效修复与再生。
中药有效成分：是指中药复方中所含有的所有与该复方临床应用目的密切相关的药理活性成分，是中药复方系统中起核心作用的一个子系统。

背景：将中药有效成分整合于水凝胶体系，作为生长因子的替代品或与生长因子相协同，有望显著增强生物材料在骨缺损修复中的治疗效能。
目的：系统总结中药有效成分在改善水凝胶材料生物相容性、机械性能等方面的优势以及中药有效成分与水凝胶协同运用促进骨修复方面的最新研究进展。
方法：以“中药，中药单体，水凝胶，载体，骨组织工程，生物材料，骨，骨修复，骨缺损”为中文检索词，以“Chinese medicine，Chinese medicine monomer，Hydrogel，Carrier，Bone tissue engineering，Bio-material，Bone，Bone repair，Bone defect”为英文检索词，检索2005-2025年期间中国知网、万方、PubMed、Web of Science数据库内的相关文献，依据纳入及排除标准，最终纳入66篇文献进行归纳总结。
结果与结论：中药有效成分可以改善水凝胶的生物相容性、机械性能及降解性能，二者联合应用突破了单一材料在力学、生物活性等方面的瓶颈。中药有效成分与水凝胶结合后，可通过调节骨代谢、促进软骨形成、抑制炎症及氧化应激、血管化与血管生成4个维度显著提升骨修复能力。然而，目前关于中药有效成分与水凝胶结合在骨组织工程中的研究仍有不足，距离实际的临床应用仍有挑战。
https://orcid.org/0009-0006-1011-6447(徐亚伟)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 中药有效成分, 水凝胶, 骨修复, 骨缺损, 骨组织工程, 生物材料

Abstract: BACKGROUND: Integrating active ingredients of traditional Chinese medicine into hydrogel systems, either as an alternative to growth factors or in synergy with growth factors, is expected to significantly enhance the therapeutic efficacy of biomaterials in bone defect repair.
OBJECTIVE: To systematically summarize the benefits of the effective ingredients of traditional Chinese medicine in enhancing the biocompatibility and mechanical properties of hydrogel materials, as well as their recent advancements in facilitating bone repair during the synergistic construction process with hydrogels.
METHODS: Chinese and English search terms were “Chinese medicine, Chinese medicine monomer, hydrogel, carrier, bone tissue engineering, bio-material, bone, bone repair, bone defect.” Relevant articles were searched from 2005 to 2025 in the CNKI, WanFang, PubMed, and Web of Science databases. Based on the inclusion and exclusion criteria, 65 articles were included for summary.
RESULTS AND CONCLUSION: Effective ingredients of traditional Chinese medicine can improve biocompatibility, mechanical capabilities, and degradation qualities of hydrogels. Their combined application overcomes the mechanical and bioactivity bottlenecks of single materials. The combination of active ingredients of traditional Chinese medicine with hydrogels significantly enhances bone repair capacity through four key dimensions: regulating bone metabolism, promoting cartilage formation, inhibiting inflammation and oxidative stress, and promoting vascularization and angiogenesis. However, current research on the combination of active ingredients of traditional Chinese medicine with hydrogels in bone tissue engineering remains inadequate, and practical clinical applications remain challenging. 

Key words: effective ingredients of traditional Chinese medicine, hydrogel, bone repair, bone defect, bone tissue engineering, biomaterial

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