中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (20): 5331-5340.doi: 10.12307/2026.150

• 生物材料综述 biomaterial review • 上一篇    下一篇

壳聚糖水凝胶载药系统治疗口腔溃疡更安全有效的解决方案

王洁燕，姚佳沂，辛颖童 ，张馨文，李日旺，刘大海   

  1. 佛山大学动物科技学院，广东省动物分子设计与精准育种重点实验室，广东省佛山市   528231 
  • 接受日期:2025-05-30 出版日期:2026-07-18 发布日期:2025-12-03
  • 通讯作者: 李日旺，讲师， 佛山大学动物科技学院，广东省动物分子设计与精准育种重点实验室，广东省佛山市 528231 刘大海，教授，佛山大学动物科技学院，广东省动物分子设计与精准育种重点实验室，广东省佛山市 528231
  • 作者简介:王洁燕，女，1999年生，广东省揭阳市人，汉族，佛山大学医学部在读硕士，主要从事生物医用材料、开发新型水凝胶材料在药物递送和组织工程中的应用方面的研究。 姚佳沂，女，2004年生，广东省深圳市人，汉族，主要从事口腔生物材料、用于口腔健康和疾病治疗的先进水凝胶技术方面的研究。
  • 基金资助:
    2023年度广东省基础与应用基础研究基金省市联合基金粤佛地区培育项目(2023A1515140076)，项目负责人：李日旺；2022年度广东省基础与应用基础研究基金省市联合基金青年项目(2022A1515110595)，项目负责人：李日旺；2024年度广东省医学科学技术研究基金项目(A2024290)，项目负责人：李日旺；国家自然科学基金项目(82270413)，项目负责人：刘大海；广东省自然科学基金项目(2023A1515011581)，项目负责人：刘大海；广东高校科技成果转化中心项目(zc03040000560)，项目负责人：刘大海；广东省普通高校重点领域专项项目(生物医药与健康)(2022ZDZX2057)，项目负责人：刘大海；佛山大学学生学术基金项目(xsjj202412zra01)，项目负责人：刘大海；佛山大学学生学术基金项目(xsjj202412zrb02)，项目负责人：李日旺

Chitosan hydrogel drug delivery system is a safer and more effective solution for treating oral ulcers

Wang Jieyan, Yao Jiayi, Xin Yingtong, Zhang Xinwen, Li Riwang, Liu Dahai   

  1. Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528231, Guangdong Province, China
  • Accepted:2025-05-30 Online:2026-07-18 Published:2025-12-03
  • Contact: Li Riwang, Lecturer, Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528231, Guangdong Province, China Liu Dahai, Professor, Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan 528231, Guangdong Province, China
  • About author:Wang Jieyan, Master candidate, Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Department of Medicine, Foshan University, Foshan 528231, Guangdong Province, China Yao Jiayi, Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Department of Medicine, Foshan University, Foshan 528231, Guangdong Province, China
  • Supported by:
    2023 Guangdong Basic and Applied Basic Research Fund (Provincial and Municipal Joint Fund) Guangdong-Foshan Region Cultivation Project, No. 2023A1515140076 (to LRW); 2022 Guangdong Basic and Applied Basic Research Fund (Provincial and Municipal Joint Fund) Youth Project, No. 2022A1515110595 (to LRW); 2024 Medical Scientific Research Foundation of Guangdong Province, No. A2024290 (to LRW); National Natural Science Foundation of China, No. 82270413 (to LDH); Guangdong Natural Science Foundation, No. 2023A1515011581 (to LDH); Guangdong University Science and Technology Achievement Transformation Center Project, No. zc03040000560 (to LDH); Guangdong Provincial General Colleges and Universities Key Field Special Project (Biomedicine and Health), No. 2022ZDZX2057 (to LDH); Foshan University Student Academic Fund Project, No. xsjj202412zra01 (to LDH); Foshan University Student Academic Fund Project, No. xsjj202412zrb02 (to LRW) 

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摘要：

文题释义：
口腔溃疡：一种常见的口腔黏膜疾病，以口腔黏膜的炎症和溃疡性损伤为特征，常由多种因素引起，影响患者饮食和生活质量。
壳聚糖水凝胶：一种基于壳聚糖的生物材料，具有良好的生物相容性和抗菌性能，结合水凝胶的高吸水性可促进伤口愈合，广泛应用于药物递送和创伤敷料等领域。

背景：壳聚糖水凝胶凭借高度适配口腔环境的多重生物学特性，成为构建理想口腔药物递送系统的重要基础材料。
目的：综述壳聚糖水凝胶载药系统在口腔溃疡治疗中的研究进展。
方法：应用计算机在 PubMed数据库和中国知网中检索各数据库建库至 2024 年9月发表的相关文献，英文检索词为“Oral ulcer, Oral mucosal injury，Drug delivery system，Stimulus response，Chitosan hydrogel，Drug deliver system，Healing mechanism” ，中文检索词为“口腔溃疡，口腔黏膜损伤，药物递送系统，刺激响应，壳聚糖水凝胶，载药系统，愈合机制”，最终纳入66篇文献进行综述。 
结果与结论：壳聚糖水凝胶因优异的生物相容性、生物可降解性和高黏附性被广泛应用于药物递送系统，特别是在口腔溃疡治疗中展现出广阔前景。壳聚糖具有良好的成膜性和缓释能力，能有效保护药物活性成分，延长药效时间，提升局部治疗效率。同时，壳聚糖具备抗菌、促组织再生等生物活性，能够直接参与溃疡部位的修复过程，减轻炎症反应，缩短愈合周期。通过与其他天然高分子或功能因子的复合，壳聚糖水凝胶的性能可进一步提升，增强水凝胶在复杂口腔环境中的适应性与稳定性。未来研究可聚焦于壳聚糖水凝胶临床疗效的深入验证、个性化给药方式的优化及智能响应型载药系统的构建，从而提高治疗精准性与患者依从性，为难治性口腔溃疡的治疗提供更安全、有效的解决方案。
https://orcid.org/0009-0009-4676-9978 (王洁燕)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 口腔溃疡, 载药系统, 壳聚糖, 壳聚糖水凝胶, 敷料, 刺激响应, 组织修复, 愈合机制, 生物材料

Abstract: BACKGROUND: Chitosan hydrogel has become an important basic material for constructing an ideal oral drug delivery system due to its multiple biological properties that are highly adapted to the oral environment. 
OBJECTIVE: To summarize the research progress of chitosan hydrogel drug delivery system in the treatment of oral ulcers.
METHODS: A computerized search was performed in PubMed and China National Knowledge Infrastructure (CNKI) databases for relevant literature published from inception to September 2024. The English and Chinese search terms were "oral ulcer, oral mucosal injury, drug delivery system, stimulus response, chitosan hydrogel, drug delivery system, healing mechanism." Finally, 66 articles were included for review. 
RESULTS AND CONCLUSION: Chitosan hydrogels are widely used in drug delivery systems, especially in oral ulcer treatment, because of their excellent biocompatibility, biodegradability, and gel-forming properties, which show a broad prospect. Chitosan has good film-forming and slow-release ability, which can effectively protect the active ingredients of drugs, prolong the efficacy time, and enhance the efficiency of local treatment. Meanwhile, chitosan has antibacterial, tissue regeneration and other biological activities, which can directly participate in the repair process of the ulcer site, reduce the inflammatory response, and shorten the healing cycle. By compounding with other natural polymers or functional factors, the performance of chitosan hydrogel can be further improved to enhance its adaptability and stability in the complex oral environment. Future research could focus on the in-depth validation of its clinical efficacy, the optimization of personalized drug delivery, and the construction of an intelligent responsive drug delivery system, so as to improve therapeutic precision and patient compliance, and provide a safer and more effective solution for the treatment of refractory oral ulcers.

Key words: oral ulcer, drug delivery system, chitosan, chitosan hydrogel, dressing, stimulus response, tissue repair, healing mechanism, biomaterial

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