中国组织工程研究

中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (27): 4306-4311.doi: 10.12307/2024.547

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

可视化分析关节软骨修复领域的研究热点与趋势

张智龙1，2，杨胜平1，2，陈天鑫2，3，朱瑜琪1，2   

  1. 1中国中医科学院眼科医院，北京市  100000；2中国中医科学院，北京市  100000；3中国中医科学院望京医院，北京市  100000
  • 收稿日期:2023-09-26 接受日期:2023-11-10 出版日期:2024-09-28 发布日期:2024-01-26
  • 通讯作者: 朱瑜琪，硕士，主任医师，中国中医科学院眼科医院，北京市 100000；中国中医科学院，北京市 100000
  • 作者简介:张智龙，男，1996年生，河北省邯郸市人，汉族，主要从事关节退行性疾病及骨伤的中西医结合特色诊治研究。
  • 基金资助:
    国家中医药管理局中医药国际合作专项(中心类项目)二次(0610-2040NF020931)，项目负责人：朱瑜琪；中国中医科学院科技创新工程项目(C12021A020)，项目负责人：朱瑜琪

Research hotspots and trends in the field of articular cartilage repair: a visualization analysis

Zhang Zhilong1, 2, Yang Shengping1, 2, Chen Tianxin2, 3, Zhu Yuqi1, 2   

  1. 1Ophthalmology Hospital, China Academy of Chinese Medical Sciences, Beijing 100000, China; 2China Academy of Chinese Medical Sciences, Beijing 100000, China; 3Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100000, China
  • Received:2023-09-26 Accepted:2023-11-10 Online:2024-09-28 Published:2024-01-26
  • Contact: Zhu Yuqi, Master, Chief physician, Ophthalmology Hospital, China Academy of Chinese Medical Sciences, Beijing 100000, China; China Academy of Chinese Medical Sciences, Beijing 100000, China
  • About author:Zhang Zhilong, Ophthalmology Hospital, China Academy of Chinese Medical Sciences, Beijing 100000, China; China Academy of Chinese Medical Sciences, Beijing 100000, China
  • Supported by:
    the Second Special Project for International Cooperation in Traditional Chinese Medicine (Center-based Project) of the National Administration of Traditional Chinese Medicine, No. 0610-2040NF020931 (to ZYQ); Science and Technology Innovation Project of China Academy of Traditional Chinese Medicine, No. C12021A020 (to ZYQ)

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摘要：


文题释义：

关节软骨：是人体分布最广泛的承重软骨，主要由软骨细胞、软骨前体细胞、Ⅱ型胶原纤维和蛋白聚糖等组成，覆盖于关节表面，具有均匀分散关节负荷、减震和润滑等作用。
软骨组织工程：是一种利用生物医学工程重建和修复软骨组织的技术，主要通过生物材料、细胞和某些功能性活性因子等构建工程软骨，以此来进行软骨缺损的修复。


背景：由于关节软骨的自我修复能力非常有限，自然退变或创伤等引起的关节软骨缺损往往无法自行修复，进而引发或加重骨关节炎，甚至导致严重残疾，因此关节软骨损伤的修复治疗已成为临床上亟待解决的问题。

目的：运用文献计量学方法分析归纳关节软骨修复领域的研究热点及发展趋势。
方法：从Web of Science核心合集中检索2000-2023年关节软骨修复的相关文献，运用VOSviewer、Citespeace和Bibliometrix R-package进行文献计量与可视化分析。

结果与结论：关节软骨修复领域年度发文量总体呈现上升趋势，美国、中国、德国是发文量前三的国家，研究机构集中于大学和医院，哈佛大学、纽约特种外科医院、上海交通大学是发文量前三的机构。《AMERICAN JOURNAL OF SPORTS MEDICINE》是出版该领域研究文献最多的期刊，《BIOMATERIALS》则是该领域被引次数最多的期刊。“Injectable hydrogels for cartilage and bone tissue engineering”是近10年间发表的被引次数最多的文献，发文量最多的作者是Madry Henning，该领域的活跃作者相互之间形成了多个结构稳定的研究团队，不同团队间的合作有待进一步加强。关节内注射、胫骨高位截骨、水凝胶、药物递送、炎症、软骨再生及支架是当前该领域研究的热点内容，3D打印技术、生物墨水、蚕丝蛋白、可注射水凝胶、外泌体等在关节软骨修复中的应用可能是该领域研究前沿。整合各种创新技术和方法以实现更有效、持久且功能性的关节软骨再生和修复，并通过开展更多高质量的临床研究以促进相关技术和方法的临床转化可能是该领域未来的研究趋势。

https://orcid.org/0009-0001-7187-5766(张智龙)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 关节软骨, 修复, 组织工程, Citespace软件, VOSviewer软件, Bibliometrix R-package, 文献计量学, 可视化分析

Abstract: BACKGROUND: Due to the very limited ability of articular cartilage to repair itself, articular cartilage defects caused by natural degeneration or trauma often cannot be repaired on their own, which triggers or aggravates osteoarthritis and even leads to severe disability. Therefore, the repair treatment after articular cartilage injury has become an urgent clinical problem.
OBJECTIVE: To summarize the hot research topics and development trends in the field of articular cartilage repair using bibliometric analysis.
METHODS: Literature related to articular cartilage repair was searched from the Web of Science Core Collection from 2000 to 2023, and bibliometric and visualization analyses were carried out using VOSviewer, Citespeace and Bibliometrix R-package.
RESULTS AND CONCLUSION: The annual publication volume in the field of articular cartilage repair shows an overall increasing trend, with the United States, China, and Germany being the top three countries in terms of publication volume, and the research institutions focus on universities and hospitals, with Harvard University, New York Hospital for Special Surgery, and Shanghai Jiao Tong University being the top three institutions in terms of publication volume. AMERICAN JOURNAL OF SPORTS MEDICINE is the journal that publishes the most research literature in the field, and BIOMATERIALS is the journal with the highest number of citations in the field. “Injectable hydrogels for cartilage and bone tissue engineering” is the most cited document published in the last decade, and the author with the most publications is Madry Henning, an active author in the field. The active authors in this field have formed a number of stable research teams with each other, and the cooperation between different teams needs to be further strengthened. Intra-articular injections, high tibial osteotomies, hydrogels, drug delivery, inflammation, cartilage regeneration, and scaffolds are the current hot topics of research in this field, and the application of 3D printing technology, bio-inks, silk proteins, injectable hydrogels, and exosomes in articular cartilage repair may be the frontier of research in this field. Integrating various innovative technologies and methods for more effective, durable and functional cartilage tissue regeneration and repair, and facilitating the clinical translation of the relevant technologies and methods by conducting more high-quality clinical studies may be the future research trend in this field.

Key words: articular cartilage, repair, tissue engineering, Citespace, VOSviewer, Bibliometrix R-package, bibliometrics, visual analysis

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