中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (32): 5162-5170.doi: 10.12307/2021.219
• 组织构建综述 tissue construction review • 上一篇 下一篇
范重山1,孙明帅1,韩文朝1,2
收稿日期:
2020-10-16
修回日期:
2020-10-20
接受日期:
2020-11-09
出版日期:
2021-11-18
发布日期:
2021-07-26
通讯作者:
韩文朝,硕士生导师,主任医师,河南中医药大学,河南省郑州市 451200;河南中医药大学附属医院(濮阳市中医院) ,河南省濮阳市 457000
作者简介:
范重山,男,1994年生,河南省郸城县人,汉族,河南中医药大学在读硕士,医师,主要从事中医药防治骨关节病的研究
Fan Chongshan1, Sun Mingshuai1, Han Wenchao1, 2
Received:
2020-10-16
Revised:
2020-10-20
Accepted:
2020-11-09
Online:
2021-11-18
Published:
2021-07-26
Contact:
Han Wenchao, Master’s supervisor, Chief physician, Henan University of Chinese Medicine, Zhengzhou 451200, Henan Province, China; Affiliated Hospital of Henan University of Chinese Medicine (Puyang Hospital of Traditional Chinese Medicine), Puyang 457000, Henan Province, China
About author:
Fan Chongshan, Master candidate, Physician, Henan University of Chinese Medicine, Zhengzhou 451200, Henan Province, China
摘要:
文题释义:
骨关节炎治疗:轻中度骨关节炎主要通过口服或者关节内注射镇痛药、抗炎药以及营养物质等缓解病情;重度骨关节炎可通过关节置换手术进行治疗。
正常关节中炎症因子的作用:在正常关节中软骨细胞的凋亡和增殖以及细胞外基质降解和合成均处于动态平衡中,其中白细胞介素1、白细胞介素6、白细胞介素17、C-反应蛋白、肿瘤坏死因子α等多种细胞因子参与这种动态平衡。
背景:虽然已经提出了一些与骨关节炎相关的危险因素,包括遗传易感性、衰老、肥胖、关节结构及力线异常等,但骨关节炎的发病机制在很大程度上仍不清楚。
目的:综述国内外相关文献,总结促炎因子及基质金属蛋白酶在骨关节炎中的作用机制及相关治疗进展。
方法:第一作者以“骨关节炎,白细胞介素1,白细胞介素6,白细胞介素17,C-反应蛋白,肿瘤坏死因子α,基质金属蛋白酶,治疗”为中文检索词,以“osteoarthritis,Interleukin-1,Interleukin-6,Interleukin-17,C-reactive protein,tumor necrosis factor-α,matrix metalloproteinase,treatment”为英文检索词,检索1990年1月以来PubMed和中国知网数据库收录的基础及临床研究。
结果与结论:①骨关节炎是一种由多种因素导致的关节疾病,发病机制复杂,主要受到多种信号通路的调控,其中炎症细胞因子及基质金属蛋白酶在骨关节炎发病机制中的作用已经越来越明显,调控着骨关节炎的发生和发展,但仍需要更深入的研究探讨;②相信在不远的将来,明确骨关节炎的致病机制,探究新型的治疗手段,特别是干细胞疗法、基因治疗等方法的引入,有望使今后对骨关节炎的治疗和预防更具针对性。
中图分类号:
范重山, 孙明帅, 韩文朝. 促炎因子及基质金属蛋白酶在骨关节炎发病机制及相关治疗中的地位和作用[J]. 中国组织工程研究, 2021, 25(32): 5162-5170.
Fan Chongshan, Sun Mingshuai, Han Wenchao. Proinflammatory factors and matrix metalloproteinases: status and roles in the pathogenesis of osteoarthritis[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(32): 5162-5170.
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文题释义:
骨关节炎治疗:轻中度骨关节炎主要通过口服或者关节内注射镇痛药、抗炎药以及营养物质等缓解病情;重度骨关节炎可通过关节置换手术进行治疗。
正常关节中炎症因子的作用:在正常关节中软骨细胞的凋亡和增殖以及细胞外基质降解和合成均处于动态平衡中,其中白细胞介素1、白细胞介素6、白细胞介素17、C-反应蛋白、肿瘤坏死因子α等多种细胞因子参与这种动态平衡。
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
骨关节炎是力学因素和生物学因素作用下软骨合成和降解偶联失衡的结果,目前研究认为,软骨组织基质金属蛋白酶的异常增高可能是导致软骨细胞外基质合成与降解失衡的重要原因。另外,软骨不论以何种形式发生退变,都离不开炎症介质的作用。通过调控炎症因子及基质金属蛋白酶的表达,参与许多骨关节炎相关事件,包括软骨细胞外基质合成与降解失衡、软骨细胞凋亡以及滑膜炎症等。
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