[1] 汪亮,刘耀升,刘蜀彬.糖皮质激素诱导股骨头坏死发病机制的研究进展[J].中华损伤与修复杂志(电子版),2015,10(5):439-445.
[2] 陈镇秋,何伟,魏秋实,等.激素性股骨头坏死患者骨组织中骨代谢相关因子的表达[J].中华关节外科杂志(电子版),2015,9(2):183-188.
[3] FANG SH, LI YF, JIANG JR, et al. Relationship of α2-Macroglobulin with Steroid-Induced Femoral Head Necrosis: A Chinese Population-Based Association Study in Southeast China. Orthop Surg. 2019;11(3):481-486.
[4] WANG A, REN M, WANG J. The pathogenesis of steroid-induced osteonecrosis of the femoral head: A systematic review of the literature. Gene. 2018;671:103-109.
[5] LI H, LIU D, LI C, et al. Exosomes secreted from mutant-HIF-1α-modified bone-marrow-derived mesenchymal stem cells attenuate early steroid-induced avascular necrosis of femoral head in rabbit. Cell Biol Int. 2017; 41(12):1379-1390.
[6] 章晓云,李华南,陈跃平.淫羊藿苷防治股骨头坏死分子机制研究进展[J].中国骨质疏松杂志,2020,26(11):1694-1699.
[7] XIE X, PEI F, WANG H,et al. Icariin: A promising osteoinductive compound for repairing bone defect and osteonecrosis. J Biomater Appl. 2015;30(3):290-299.
[8] 万亚宁,李双蕾,蒋云霞,等.淫羊藿及其复方制剂治疗糖皮质激素性骨质疏松症的研究进展[J].中国骨质疏松杂志,2019,25(5): 713-716.
[9] LIU RH, KANG X, XU LP, et al. Effects of the Combined Extracts of Herba Epimedii and Fructus Ligustri Lucidi On Bone Mineral Content and Bone Turnover in Osteoporotic Rats. BMC Complement Altern Med. 2015;15:112.
[10] ZHANG D, FONG C, JIA Z, et al. Icariin Stimulates Differentiation and Suppresses Adipocytic Transdifferentiation of Primary Osteoblasts through Estrogen Receptor-Mediated Pathway. Calcif Tissue Int. 2016; 99(2):187-198.
[11] MA HP, MA XN, GE BF, et al. Icariin Attenuates Hypoxia-Induced Oxidative Stress and Apoptosis in Osteoblasts and Preserves their Osteogenic Differentiation Potential in Vitro. Cell Prolif. 2014;47(6):527-539.
[12] 钱卫庆. 淫羊藿苷促成骨细胞增殖中非核效应及机制研究[D]. 苏州:苏州大学, 2016.
[13] WANG P, ZHANG F, HE Q, et al.Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair. PLoS One. 2016;11(2):e0148372.
[14] WANG Z, WANG D, YANG D, et al. The effect of icariin on bone metabolism and its potential clinical application. Osteoporos Int. 2018;29(3):535-544.
[15] 秦爽,刘红,刘称称,等.淫羊藿苷影响骨代谢的研究[J].现代口腔医学杂志,2018,32(5):303-306.
[16] YANG Y, NIAN H, TANG X, et al. Effects of the Combined Herba Epimedii and Fructus Ligustri Lucidi On Bone Turnover and TGF-beta1/Smads Pathway in GIOP Rats. J Ethnopharmacol. 2017;201:91-99.
[17] 陈喆.淫羊藿苷对RAW264.7细胞破骨分化中MAPK信号通路的影响探究[D].北京:首都医科大学,2017.
[18] 杨卫,赵品,陶美玲,等.淫羊藿苷口服给药对骨质疏松牙周炎小鼠牙槽骨吸收的影响[J].上海口腔医学,2019,28(1):30-35.
[19] KAHN M.Can we safely target the WNT pathway.Nat Rev Drug Discov. 2014; 13(7):513-532.
[20] FU S, YANG L, HONG H, et al. Wnt/β-catenin signaling is involved in the Icariin induced proliferation of bone marrow mesenchymal stem cells. J Tradit Chin Med. 2016;36(3):360-368.
[21] WANG Z, WANG D, YANG D, et al. The effect of icariin on bone metabolism and its potential clinical application. Osteoporos Int. 2018;29(3):535-544.
[22] YANG A, YU C, LU Q, et al. Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells. Stem Cells Int. 2019;2019:5747298.
[23] WEI Q, ZHANG J, HONG G, et al. Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERα- Wnt/β- catenin signaling pathway. Biomed Pharmacother. 2016;84: 931-939.
[24] LIU Y, HUANG L, HAO B, et al. Use of an Osteoblast Overload Damage Model to Probe the Effect of Icariin on the Proliferation, Differentiation and Mineralization of MC3T3-E1 Cells through the Wnt/β-Catenin Signalling Pathway. Cell Physiol Biochem. 2017;41(4):1605-1615.
[25] WANG J, TAO Y, PING Z, et al. Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro. Sci Rep. 2016;6:23827.
[26] ZHOU H, JIAO G, DONG M, et al. Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. Biol Trace Elem Res. 2019;190(2):327-335.
[27] DIBBLE C, CANTLEY L. Regulation of mTORC1 by PI3K signaling. Trends Cell Biol. 2015;25(9):545-555.
[28] FRUMAN D, ROMMEL C. PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov. 2014;13(2): 140-156.
[29] THORPE L, YUZUGULLU H, ZHAO J. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer. 2015;15(1):7-24.
[30] ZOU H, LI L, GARCIA CARCEDO I, et al. Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/mTOR dual inhibitor BEZ235 through apoptosis. Int J Nanomedicine. 2016;11:1947-1958.
[31] MANNING BD, TOKER A. AKT/PKB Signaling: Navigating the Network.Cell. 2017;169(3):381-405.
[32] XUE XH, FENG ZH, LI ZX, et al. Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K/Akt signaling pathway: In vitro and in vivo studies. Mol Med Rep. 2018;17(3):3751-3757.
[33] LU JM, ZHANG ZZ, MA X, et al. Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. Exp Eye Res. 2020;190:107886.
[34] AHMAD KA, ZE H, CHEN J, et al. The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways. Biomed Pharmacother. 2018;106:1734-1741.
[35] 王雅婧,张学志,刁力,等.PI3K/AKt/eNOS信号通路在硫化氢抑制ET-1诱导的心肌肥大中的作用[J].中国循证心血管医学杂志, 2014,6(5):551-554+557.
[36] HU J, MAO Z, HE S, et al. Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway. Biochem Pharmacol. 2017;136:109-121.
[37] 宋世雷,陈跃平,章晓云.PI3K/AKT信号通路调控股骨头坏死的相关机制[J].中国组织工程研究,2020,24(3):408-415.
[38] ZHOU H, JIAO G, DONG M, et al. Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. Biol Trace Elem Res. 2019;190(2):327-335.
[39] BERTACCHINI J, HEIDARI N, MEDIANI L, et al. Targeting PI3K/AKT/mTOR network for treatment of leukemia. Cell Mol Life Sci. 2015;72(12): 2337-2347.
[40] FOLLO MY, MANZOLI L, POLI A, et al. PLC and PI3K/Akt/mTOR signalling in disease and cancer. Adv Biol Regull. 2015;57:10-16.
[41] MANFREDI GI, DICITORE A, GAUDENZI G, et al. PI3K/Akt/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy. Endocrine. 2015;48(2):363-370.
[42] GUO X, WEI S, LU M, et al. Dose-dependent effects of strontium ranelate on ovariectomy rat bone marrow mesenchymal stem cells and human umbilical vein endothelial cells. Int J Biol Sci. 2016;12(12):1511-1522.
[43] JIANG S, CHANG H, DENG S, et al. Icariin inhibits autophagy and promotes apoptosis in SKVCR cells through mTOR signal pathway. Cell Mol Biol (Noisy-le-grand). 2018;64(6):4-10.
[44] LUO G, XU B, HUANG Y. Icariside II promotes the osteogenic differentiation of canine bone marrow mesenchymal stem cells via the PI3K/AKT/mTOR/S6K1 signaling pathways. Am J Transl Res. 2017;9(5):2077-2087.
[45] LI G, HU J, CHEN H, et al. Enamel matrix derivative enhances the proliferation and osteogenic differentiation of human periodontal ligament stem cells on the titanium implant surface. Organogenesis. 2017;13(3):103-113.
[46] TONG Y, FENG W, WU Y, et al. Mechano-growth factor accelerates the proliferation and osteogenic differentiation of rabbit mesenchymal stem cells through the PI3K/AKT pathway. BMC Biochem. 2015;16:1.
[47] YAO X, JING X, GUO J, et al. Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission,PI3K/AKT/mTOR and MAPK Pathways. Front Pharmacol. 2019;10:163.
[48] CIPOLLETTI M, MONTALESI E, NUZZO MT, et al. Potentiation of paclitaxel effect by resveratrol in human breast cancer cells by counteracting the 17β-estradiol/estrogen receptor α/neuroglobin pathway. J Cell Physiol. 2019;234(4):3147-3157.
[49] XU YX, XU B, WU CL, et al. Dynamic expression of DKK1 protein in the process whereby Epimedium-derived flflavonoids up-regulate osteogenic and down-regulate adipogenic differentiation of bone marrow stromal cells in ovariecto mized rats. Orthop Surg. 2011;3:119-126.
[50] ZHOU L, POON CC, WONG KY, et al. Prenylflavonoid Icariin Induces Estrogen Response Element-Independent Estrogenic Responses in a Tissue-Selective Manner. J Endocr Soc. 2019;4(2):bvz025.
[51] ZHAO R, BU W, CHEN Y.Icariin Treatment Enhanced the Skeletal Response to Exercise in Estrogen-Deficient Rats. Int J Environ Res Public Health. 2019; 16(19):3779.
[52] ZHANG D, FONG C, JIA Z, et al. Icariin Stimulates Differentiation and Suppresses Adipocytic Transdifferentiation of Primary Osteoblasts Through Estrogen Receptor-Mediated Pathway. Calcif Tissue Int. 2016;99(2):187-198.
[53] 邓宇,陈廖斌.淫羊藿苷通过激活Notch信号通路促进骨髓间充质干细胞向成骨细胞分化的实验研究[J].中医学报,2017,32(12): 2393-2398,2403.
[54] YANG M, LIU H, WANG Y, et al. Hypoxia reduces the osteogenic differentiation of peripheral blood mesenchymal stem cells by upregulating Notch-1 expression. Connect Tissue Res. 2019;60(6):583-596.
[55] XU Y, LI L, TANG Y, et al. Icariin promotes osteogenic differentiation by suppressing Notch signaling. Eur J Pharmacol. 2019;865:172794.
[56] 李智奎,孔俊博,赵王林.淫羊藿苷调控Wnt/β-catenin信号通路干预大鼠MSCs成脂成骨双向分化实验研究[J].中国免疫学杂志, 2019,35(24):2985-2990.
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