中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (49): 9275-9278.doi: 10.3969/j.issn.1673-8225.2011.49.036

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

内源性神经干细胞治疗脊髓损伤

张  诚，陈  刚   

  1. 新疆医科大学自治区人民医院临床学院，新疆维吾尔自治区乌鲁木齐市  830001
  • 收稿日期:2011-05-16 修回日期:2011-08-26 出版日期:2011-12-03 发布日期:2011-12-03
  • 通讯作者: 陈刚，博士，副主任医师，新疆维吾尔自治区人民医院神经外科，新疆维吾尔自治区乌鲁木齐市 830001 jhy_501@163.com
  • 作者简介:张诚★，男，1986年生，新疆维吾尔自治区克拉玛依市人，汉族，新疆医科大学在读硕士，主要从事神经干细胞研究。 zhangyujunwei@126.com
  • 基金资助:

    国家自然科学基金(30960393，81160155)；新疆维吾尔自治区科技攻关项(200633128(2))。

Endogenous neural stem cells for treatment of spinal cord injury

Zhang Cheng, Chen Gang   

  1. People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Medical University, Urumqi  830001, Xinjiang Uygur Autonomous Region, China
  • Received:2011-05-16 Revised:2011-08-26 Online:2011-12-03 Published:2011-12-03
  • Contact: Chen Gang, Doctor, Associate chief physician, Department of Neurosurgery, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China jhy_501@163.com
  • About author:Zhang Cheng★, Studying for master’s degree, People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Medical University, Urumqi 830001, Xinjiang Uygur Autonomous Region, China zhangyujunwei@126.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81160155*, 30960393*; the Science and Technology Tackle Key Project of Xinjiang Uygur Autonomous Region, No. 200633128(2)*

PDF

298

被引次数

4

摘要：

背景：脊髓损伤是一种严重的神经系统疾病，使患者的生活质量严重下降。近年来，随着医学的发展，内源性神经干细胞治疗脊髓损伤作为一种治疗策略被广泛关注。
目的：文章对内源性神经干细胞的活化、分化及治疗脊髓损伤的机制做一简要的综述。
方法：应用计算机检索万方数据库和PubMed数据库中2002-01/2011-03关于神经干细胞治疗脊髓损伤的文章，在标题和摘要中以“内源性神经干细胞；脊髓损伤；分化”或“Endogenous neural stem cells；Spinal cord injury; Differentiation”为检索词进行检索。选择文章内容与内源性神经干细胞治疗脊髓损伤相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到340篇文献，根据纳入标准选择20篇文章进行综述。
结果与结论：内源性神经干细胞作为一种新型的治疗手段，它具有独特的优势，不仅避免了免疫排斥及伦理道德等方面的问题，而且在成年个体中也存在。大部分内源性神经干细胞分化成星形胶质细胞和少突胶质细胞，而不是神经元，但通过对信号传导通路的调控，可以是神经干细胞更多地分化为神经元细胞，从而发挥对脊髓损伤的治疗作用。

关键词: 内源性神经干细胞, 脊髓损伤, 神经元, 分化, 综述

Abstract:

BACKGROUND: Spinal cord injury is a serious neurological disease, and the life quality of spinal cord injury patients significantly declines. With the development of medical science, endogenous neural stem cells as a treatment strategy for spinal cord injury have attracted widespread attention in recent years.
OBJECTIVE: To summarize the activation and differentiation of endogenous neural stem cells, as well as the mechanism in treating spinal cord injury.
METHODS: A computer-based online search of Wanfang database and PubMed database from January 2002 to March 2011 was performed for related articles about neural stem cells for treatment of spinal cord injury, with key words of “endogenous neural stem cells, spinal cord injury, differentiation” in Chinese and in English, respectively, by screening titles and abstracts. The documents associated with endogenous neural stem cells for treatment of spinal cord injury were selected, and those published recently or in authoritative journals were preferred in the same field. Totally 340 articles were obtained in initial retrieval, and 20 articles of them were chosen based on inclusion criteria.
RESULTS AND CONCLUSION: Endogenous neural stem cells have unique advantages as a new treatment. They can not only avoid the immune rejection and ethical issues, but also exist in adult individuals. Most endogenous neural stem cells can differentiate into astrocytes and oligodendrocytes rather than neurons. More neural stem cells can differentiate into neurons through the regulation of signal transduction pathways, which plays an important role in the treatment of spinal cord injury.

中图分类号: