中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (49): 9279-9282.doi: 10.3969/j.issn.1673-8225.2011.49.037

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞向内皮细胞的分化和临床应用

康少平，姜文静，李  萍   

  1. 河北北方学院检验学院临检教研室，河北省张家口市  075000
  • 收稿日期:2011-06-05 修回日期:2011-09-21 出版日期:2011-12-03 发布日期:2011-12-03
  • 作者简介:康少平★，女，1981年生，河北省张家口市人，汉族，2009年天津医科大学毕业，硕士，主要从事血液学检验教学及研究工作。 kang_shao_ping@163.com

Differentiation of bone marrow mesenchymal stem cells into endothelial cells and clinical application

Kang Shao-ping, Jiang Wen-jing, Li Ping   

  1. Department of Clinical Inspection, Inspection School of Hebei North University, Zhangjiakou  075000, Hebei Province, China
  • Received:2011-06-05 Revised:2011-09-21 Online:2011-12-03 Published:2011-12-03
  • About author:Kang Shao-ping★, Master, Department of Clinical Inspection, Inspection School of Hebei North University, Zhangjiakou 075000, Hebei Province, China kang_shao_ping@163.com

PDF

342

被引次数

8

摘要：

背景：目前国内外研究初步证明，骨髓间充质干细胞可以诱导分化为血管内皮细胞。
目的：综述骨髓间充质干细胞向内皮细胞的分化和临床研究进展。
方法：应用计算机检索2000/2011 PubMed数据库相关文章，检索词为“bone marrow mesenchymal stem cell，endothelial cell，differentiation，tissue engineered”，并限定文章语言种类为English。同时计算机检索2000/2011万方数据库相关文章，检索词为“骨髓间充质干细胞，内皮细胞，分化，临床应用”，并限定文章语言种类为中文。共检索到文献418篇，最终纳入符合标准的文献31篇。
结果与结论：骨髓间充质干细胞具有自我更新和多向分化潜能，在一定的诱导条件下可以向血管内皮细胞分化。血管内皮细胞是组织工程化血管的重要组成成分。利用骨髓间充质干细胞进行血管内皮构建，既可促进组织工程化器官的血管再生，又为组织工程化器官提供血供，同时也为临床治疗缺血性疾病奠定了基础。

关键词: 内皮细胞, 骨髓间充质干细胞, 分化, 组织工程化, 综述文献

Abstract:

BACKGROUND: Studies have preliminarily verified that the bone marrow mesenchymal stem cells (BMSCs) can differentiate into endothelial cells.
OBJECTIVE: To review the differentiation of BMSCs into endothelial cells and the progress of clinical research.
METHODS: PubMed database was searched for articles published from 2000 to 2011 with the key words of “bone marrow mesenchymal stem cell, endothelial cell, differentiation, tissue engineered. The language was limited in English. Meanwhile, Wanfang database was searched for articles published from 2000 to 2011 with the key words of “bone marrow mesenchymal stem cell, endothelial cell, differentiation, clinical application” in Chinese.Totally 418 articles were retrieved, and finally 31 articles were included. .
RESULTS AND CONCLUSION: BMSCs have the potential of self renewal and multiplex differentiation. In certain conditions, they can be induced into endothelial cells. Endothelial cells are the important components of tissue-engineered blood vessels. BMSCs for endothelial construction can promote the regeneration of blood vessels in tissue-engineered organs, provide blood supply and also lay the foundation for the treatment of ischemic diseases in clinic.

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