中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (23): 4319-4324.doi: 10.3969/j.issn.1673-8225.2010.23.031

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

物理治疗因子对干细胞调控机制的影响

刘 然1，2，范洪学1，刘世文1   

  1. 1吉林大学，吉林省长春市    130021；2长春市中心血站，吉林省长春市     130021
  • 出版日期:2010-06-04 发布日期:2010-06-04
  • 通讯作者: 刘世文，吉林大学，吉林省长春市 130021 liushiwen1947@sina.com
  • 作者简介:刘 然，男，1977年生，吉林省人，汉族，吉林大学在读博士，主治医师，主要从事干细胞调控机制研究。 lr770920@163.com

Effects of physical therapy factors on mechanism of stem cell regulation

Liu Ran1,2, Fan Hong-xue1, Liu Shi-wen1   

  1. 1Jilin University, Changchun  130021, Jilin Province, China; 2Changchun Municipal Central Blood Station, Changchun  130021, Jilin Province, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Liu Shi-wen, Jilin University, Changchun 130021, Jilin Province, China liushiwen1947@sina.com
  • About author:Liu Ran, Studying for doctorate, Attending physician, Jilin University, Changchun 130021, Jilin Province, China; Changchun Municipal Central Blood Station, Changchun 130021, Jilin Province, China lr770920@163.com

PDF

444

被引次数

9

摘要：

背景：化学性因子对干细胞调控机制的研究是当前国内外的热点。但许多研究证实物理因子刺激也可以干预干细胞的调控，使其向目的细胞定向分化及产生功能。
目的：探讨某些物理因子对干细胞定向分化的实际应用价值。
方法：就近10年国内外常用物理治疗因子对干细胞增殖分化影响的论文约102篇作一回顾，其中脉冲磁场刺激、经颅磁刺激、脉冲电（电针）刺激、超声波治疗、高压氧、力学刺激(pulsed electromagnetic fields , transcranial magnetic stimulation ，Low Frequency Impulse Electrotherapy, Ultrasonic Therapy, high pressure oxygen，various mechanical stress)的研究报告略多，认为这些物理因子可促进干细胞增殖分化，而运动训练及弱直流电刺激因子(treadmill  training，direct current stimulation)的研究报告甚少，可能受限于研究思路或手段，没有确切的共识或报告信息。
结果与结论：物理因子作用于干细胞的机制比较复杂，其可能参与了包括细胞因子和生长因子在内的生物化学环境共同组成的细胞生长微环境，可能对细胞因子等生物化学信息提供补充或协调作用。

关键词: 定向分化, 干细胞, 物理因子, 刺激, 调控, 综述文献

Abstract:

BACKGROUND: It is a hot focus on research for mechanism of stem cells modulated by chemical factors at present. But, many researches have shown that physical factors stimulation might also interfere in stem cell modulation to make target cell differentiation and generate function.  
OBJECTIVE: To explore the application value of some physical factors on stem cell oriented differentiation. 
METHODS: We reviewed about 102 research papers on common physical therapy factors on stem cell multiplication and differentiation in ten years. It was found that many researches much more concentrated on pulsed electromagnetic fields, transcranial magnetic stimulation, low frequency impulse electrotherapy, ultrasonic therapy, high pressure oxygen and various mechanical stress, which presumed that these physical factors might facilitate stem cell multiplication and differentiation, while few research on treadmill training and direct current stimulation showed that there might be no exact concern or report because of restriction on research thought or means.
RESULTS OR CONCLUSION: The mechanism of physical factors interfering stem cells is complex. Physical factors might participate in cell growth microenvironment composed by biochemical environments including cell factors and growth factors and might have a supplementary or coordinated role in providing biochemical information such as cell factors.

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