中国组织工程研究

中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (29): 5357-5363.doi: 10.3969/j.issn.2095-4344.2013.29.015

• 药物控释材料 drug delivery materials • 上一篇    下一篇

凝聚法制备明胶类磁性微囊

冼远芳，王文廷，于 玮，屠立辉，王圣海，邹 成，闵小峰   

  1. 长春工业大学化工学院，吉林省长春市 130012
  • 收稿日期:2012-11-15 修回日期:2012-12-17 出版日期:2013-07-22 发布日期:2013-07-22
  • 作者简介:冼远芳，女，1959年生，广西壮族自治区贵港市人，广西大学化工学院毕业，副教授，主要从事药物新剂型的研究。 xyfllg@126.com
  • 基金资助:

    吉林省教育厅“十二五”科学技术研究项目(吉教科合字[2012]第107号)

Preparation of gelatin-magnetic micro-capsules by condensation method

Xian Yuan-fang, Wang Wen-ting, Yu Wei, Tu Li-hui, Wang Sheng-hai, Zou Cheng, Min Xiao-feng   

  1. School of Chemical Engineering, Changchun University of Technology, Changchun 130012, Jilin Province, China
  • Received:2012-11-15 Revised:2012-12-17 Online:2013-07-22 Published:2013-07-22
  • About author:Xian Yuan-fang, Associate professor, School of Chemical Engineering, Changchun University of Technology, Changchun 130012, Jilin Province, China xyfllg@126.com
  • Supported by:

    Science and Technology Research Program of Jilin Provincial Education Ministry During the Twelfth Five-Year Plan, No. 2012107*

PDF

704

被引次数

5

摘要：

背景：与传统的给药方法相比，药物微囊系统可以控制药物的释放，具有良好的靶向性和生物相容性，可将药物浓聚在病灶组织，在临床上起到巨大作用。
目的：将不同囊材与明胶复凝聚制备达卡巴嗪磁性微囊(以下简称磁性微囊)，探讨最佳囊材及制备工艺。
方法：采用化学共沉淀法制备Fe3O4磁性材料。采用溶液复凝聚法分别制备明胶-阿拉伯胶磁性微囊、明胶-海藻酸钠磁性微囊、明胶-羧甲基纤维素钠磁性微囊、明胶-壳聚糖磁性微囊；再分别采用乳液复凝聚法制备明胶-阿拉伯胶磁性微囊、明胶-海藻酸钠磁性微囊、明胶-羧甲基纤维素钠磁性微囊、明胶-壳聚糖磁性微囊；采用单凝聚法分别制备明胶及壳聚糖磁性微囊。以微囊的包埋率、磁化率、微囊尺寸和释放性能为评价指标，确定磁性微囊的最佳制备工艺。
结果与结论：溶液复凝聚法好于乳液复凝聚法，采用溶液复凝聚法制备磁性微囊较好的囊材是明胶-海藻酸钠，药物包埋率37.90%，收率72.31%，平均磁化强度8.53 emu/g，其次是明胶-壳聚糖。单凝聚法囊材明胶好于壳聚糖，药物包埋率51.58%、收率64.50%、平均磁化强度6.93 emu/g。单凝聚法制备工艺优于复凝聚法。

关键词: 生物材料, 生物材料与药物控释, 复凝聚法, 明胶, 海藻酸钠, 壳聚糖, 缓释微囊, 磁性能, 制备方法, 累积释放度, 省级基金

Abstract:

BACKGROUND: Compared with conventional medications, drug micro-capsule system can control the release of drugs and have well target properties and biocompatibility. The drugs can be concentrated at the focus and play an important role in clinic.
OBJECTIVE: To prepare dacarbazine magnetic micro-capsules with different capsule materials and gelatin complex by coacervation, and to optimize capsule materials and preparation process.
METHODS: Fe3O4 magnetic materials were prepared with chemical coprecipitation method. With the solution complex coacervation, we prepared the gelatin-Arabic gum magnetic micro-capsule, gelatin-sodium alginate magnetic micro-capsules, gelatin-sodium carboxymethyl cellulose magnetic micro-capsules, and gelatin-chitosan magnetic micro-capsules. With the emulsion complex coacervation method, we further prepared the gelatin-Arabic gum magnetic micro-capsule, gelatin-sodium alginate magnetic micro-capsules, gelatin-sodium carboxymethyl cellulose magnetic micro-capsules, and gelatin-chitosan magnetic micro-capsules. The magnetic gelatin micro-capsules and magnetic chitosan micro-capsules were prepared with single coagulation method. The micro-capsules were determined for the embedding rate, the magnetic susceptibility, the micro-capsule size and the release performance, to define the optimal preparation technology of dacarbazine magnetic micro-capsules.
RESULTS AND CONCLUSION: The solution complex coacervation method was better than the emulsion coacervation method. As for the solution complex coacervation method, the optimal capsule material was gelatin-sodium alginate, with drug embedding rate 37.90%, the yield rate 72.31%, and the average magnetization intensity 8.53 emu/g. The second material was gelatin-chitosan. As a capsule material, the gelatin was better than chitosan with single coagulation method. Drug embedding rate was 51.58%, the yield rate was 64.50%, and the average magnetization was 6.93 emu/g. Single coagulation method was better than coacervation method.

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