中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (18): 2927-2932.doi: 10.3969/j.issn.2095-4344.0749

• 生物材料综述 biomaterial review • 上一篇    下一篇

透明质酸及其衍生物影响成骨细胞功能:分子机制与应用价值

狄嘉伟,李 想,谢瑞敏,王勇平   

  1. 兰州大学第一医院骨科,甘肃省兰州市 730000
  • 收稿日期:2018-02-06 出版日期:2018-06-28 发布日期:2018-06-28
  • 通讯作者: 王勇平,博士,博士后,研究生导师,兰州大学第一医院骨科,甘肃省兰州市 730000
  • 作者简介:狄嘉伟,男,1996年生,山东省嘉祥县人,汉族,兰州大学在读本科生,主要从事关节外科、创伤骨科及骨科生物材料方面的研究。
  • 基金资助:

    兰州市科技计划项目(2017-4-58)

Effect of hyaluronic acid and its derivatives on osteoblast function: molecular mechanisms and clinical values

Di Jia-wei, Li Xiang, Xie Rui-min, Wang Yong-ping   

  1. Department of Orthopedics, First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
  • Received:2018-02-06 Online:2018-06-28 Published:2018-06-28
  • Contact: Wang Yong-ping, M.D., Master’s supervisor, Department of Orthopedics, First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
  • About author:Di Jia-wei, Department of Orthopedics, First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
  • Supported by:

    the Scientific Research Plan Program of Lanzhou City, No. 2017-4-58

摘要:

文章快速阅读:

 

文题释义:
透明质酸:D-葡萄糖醛酸及N-乙酰葡糖胺组成的双糖单位玻尿酸,又称糖醛酸、透明质酸,广泛分布于人和动物各组织中,如关节滑液、滑膜、软骨等,是关节软骨基质的重要组成成分,是细胞外基质中一种高分子量的多糖聚合物。其出色的流变性能、润滑性、渗透性、保水作用和特殊的黏弹性,是调节细胞生长、增殖、分化和迁移的重要因素。
化学改性:是通过化学反应改变聚合物的物理、化学性质的方法。如聚苯乙烯的硬链段刚性太强,可引进聚乙烯软链段,增加韧性;尼龙、聚酯等聚合物的端基(氨基、羧基、羟基等),可用一元酸(苯甲酸或乙酸酐)、一元醇(环己醇、丁醇或苯甲醇等)进行端基封闭;由多元醇与多元酸缩聚而成的醇酸聚酯耐水性及韧性差,加入脂肪酸进行改性后可以显著提高它的耐湿性和耐水性,弹性也相应提高。
 
 
背景:透明质酸作为细胞外基质的重要组成部分,在多种生物过程中起着重要的作用。透明质酸具有良好的生物相容性、可降解性和非免疫原性,是构建各种形态、硬度和生物活性材料的理想原材料。
目的:分析透明质酸及其衍生物对成骨细胞生长分化的作用。
方法:检索CNKI,PubMed 数据库,以“透明质酸,成骨细胞”为中文检索词,“hyaluronic acid,osteoblasts”为英文检索词,检索有关透明质酸对成骨细胞影响作用的文章。共检索到81篇文献,通过阅读文题、摘要进行初筛,排除无关的或内容重复的文献,最后纳入符合标准的34篇文献作进一步分析。

结果与结论:①透明质酸广泛应用于对细胞黏附和迁移,血管生成和形态发生,伤口愈合,炎症反应以及癌症转移的研究中;②透明质酸及其相关生物材料对成骨细胞生长分化具有积极的影响作用。同时可以作为分子伴侣来保护被包裹的生长因子及药物,在特定部位缓释以实现对所需细胞功能的调控;作为潜在的新型临床生物材料,可用于开发组织工程支架材料、药物缓释媒介、生长因子靶向载体等;③随着现代医学的研究重点朝着“学科交叉”的集中,更加智能和个性化的透明质酸水凝胶材料将是未来医学材料研究领域的热点。

ORCID: 0000-0003-2299-6892(狄嘉伟)

关键词: 生物材料, 药物缓释, 组织修复, 透明质酸, 成骨细胞, 骨折修复, 生长因子, 支架, 化学改性, 组织工程, 靶向载体, 综述

Abstract:

BACKGROUND: Hyaluronic acid, as an important part of extracellular matrix, plays an important role in various biological processes. Hyaluronic acid has good biocompatibility, biodegradability and non-immunogenicity. It is an ideal raw material to prepare a variety of materials with different morphologies, hardness, and bioactivities.

OBJECTIVE: To analyze the effect of hyaluronic acid and its derivatives on osteoblast growth and differentiation.
METHODS: The CNKI and PubMed databases were searched with the key words of “hyaluronic acid, osteoblast” in Chinese and English, respectively. Initially 81 articles were retrieved, and only 34 eligible articles were included in result analysis after removal of unrelated or duplicate literature.

RESULTS AND CONCLUSION: Hyaluronic acid has been widely used in the studies on cell adhesion and migration, angiogenesis and morphogenesis, wound healing, inflammation and cancer metastasis. Hyaluronic acid and its related biomaterials have a positive effect on osteoblast growth and differentiation. Hyaluronic acid and its related biomaterials can serve as molecular chaperones to protect the encapsulated growth factors and drugs, and release them in specific sites to achieve the regulation of desired cellular functions. As a potential new clinical biomaterial, it can be used for the development of tissue engineering scaffolds, drug sustained-release media, and growth factor targeting vectors. As the modern medicine is focusing on the “interdisciplinary”, hyaluronic acid hydrogel materials that are more intelligent and personalized will be the research focus of future medical materials.

 

Key words: Hyaluronic Acid, Osteoblasts;, Biocompatible Materials, Tissue Engineering

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