中国组织工程研究

中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (16): 2989-2993.doi: 10.3969/j.issn.2095-4344.2013.16.020

• 材料力学及表面改性 material mechanics and surface modification • 上一篇    下一篇

纳米羟基磷灰石的制备及改性

庞桂花1，3，程志强2，3，李俊锋3   

  1. 1东岳集团研究院，山东省淄博市  256400
    2吉林农业大学资源与环境学院，吉林省长春市  130118
    3吉林大学化学学院，吉林省长春市  130012
  • 收稿日期:2012-07-09 修回日期:2012-08-12 出版日期:2013-04-16 发布日期:2013-04-16
  • 通讯作者: 程志强，吉林农业大学资源与环境学院，吉林省长春市 130118 czq5974@163.com
  • 作者简介:庞桂花★，女，1984年生，山东省菏泽市人，汉族，2010年吉林大学化学学院毕业，硕士，主要从事生物医用材料研究。 pangguihua1984@163.com

Preparation and modification of nano-hydroxyapatite

Pang Gui-hua 1,3, Cheng Zhi-qiang 2,3, Li Jun-feng3   

  1. 1 Dongyue Group Institute, Zibo  256400, Shandong Province, China
    2 College of Resources and Environment, Jilin Agricultural University, Changchun  130118, Jilin Province, China
    3 Chemistry College, Jilin University, Changchun  130012, Jilin Province, China
  • Received:2012-07-09 Revised:2012-08-12 Online:2013-04-16 Published:2013-04-16
  • Contact: Cheng Zhi-qiang, College of Resources and Environment, Jilin Agricultural University, Changchun 130118, Jilin Province, China; Chemistry College, Jilin University, Changchun 130012, Jilin Province, China czq5974@163.com
  • About author:Pang Gui-hua★, Master, Dongyue Group Institute, Zibo 256400, Shandong Province, China; Chemistry College, Jilin University, Changchun 130012, Jilin Province, China pangguihua1984@163.com

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1510

被引次数

11

摘要：

背景：人工制得的羟基磷灰石具有较强的比表面，极易发生团聚。
目的：解决羟基磷灰石团聚问题，使其分散性更好。
方法：以硝酸钙和磷酸二氢氨为原料，采用溶液共沉淀法制备纳米羟基磷灰石，分别应用聚乙二醇(2%，4%，5%，6%，8%)、聚乙烯醇(2%，4%，5%，6%，8%)、硬脂酸(2%，4%，5%，6%，8%)对其进行改性。
结果与结论：X射线衍射分析显示获得了纯度较高的纳米羟基磷灰石。在表面包覆改性纳米羟基磷灰石时，表面改性剂种类、活性剂浓度等都对其粒径大小产生影响。综合考察羟基磷灰石合成及改性过程中的影响因素主要得出以下结论：通过对羟基磷灰石改性，羟基磷灰石对聚乙二醇、聚乙烯醇、硬脂酸具有一定的选择性，聚乙二醇对羟基磷灰石改性最好，且浓度为5%时羟基磷灰石分散性最好。

关键词: 生物材料, 材料力学及表面改性, 纳米羟基磷灰石, 纳米改性, 分散剂, 溶液共沉淀方法, 纳米团聚, 表面改性剂, 聚乙二醇, 聚乙烯醇, 硬脂酸

Abstract:

BACKGROUND: The prepared hydroxyapatite is likely agglomerated due to its specific surface area.
OBJECTIVE: To investigate the agglomeration problem of hydroxyapatite and to improve the dispersity of hydroxyapatite.
METHODS: The nano-hydroxyapatite was prepared using solution coprecipitation method from calcium nitrate and ammonium di-hydrogen phosphate and further modified by combination of polyethylene glycol (2%, 4%, 5%, 6%, 8%), polyvinyl alcohol (2%, 4%, 5%, 6%, 8%), and stearic acid (2%, 4%, 5%, 6%, 8%).
RESULTS AND CONCLUSION: Nano-hydroxyapatite was successfully obtained through X-ray diffraction analysis. The type of surface modifying agent and active agent concentration could affect the particle size of the hydroxyapatite when cladded by them. After considering the influential factors in processes of synthesis and modification, the following conclusions can be determined: Polyethylene glycol is the best modifying agent for hydroxyapatite in all three modifying agents which involve polyethylene glycol, polyvinyl alcohol and stearic acid. Furthermore, the dispersity of the hydroxyapatite is excellent after modification by 5% polyethylene glycol.

Key words: biomaterials, material mechanics and surface modification, nano-hydroxyapatite, nano-modification, dispersing agent, solution coprecipitation method, nano-agglomeration, surface modifying agent, polyethylene glycol, polyvinyl alcohol, stearic acid

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