中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (10): 1585-1591.doi: 10.3969/j.issn.2095-4344.3033
• 生物材料综述 biomaterial review • 上一篇 下一篇
柏 雪,王 彬,何斯荣
收稿日期:
2020-04-09
修回日期:
2020-04-15
接受日期:
2020-06-12
出版日期:
2021-04-08
发布日期:
2020-12-18
通讯作者:
何斯荣,重庆医科大学基础医学院免疫学教研室,重庆市 40001
作者简介:
柏雪,女,1994年生,重庆市人,汉族,重庆医科大学医学在读硕士,主要从事自身免疫性疾病研究。
基金资助:
Bai Xue, Wang Bin, He Sirong
Received:
2020-04-09
Revised:
2020-04-15
Accepted:
2020-06-12
Online:
2021-04-08
Published:
2020-12-18
Contact:
He Sirong, Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China
About author:
Bai Xue, Master candidate, Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China
Supported by:
摘要:
文题释义:
胰岛移植:是指将从供者胰腺中分离出来的胰岛移植到受者体内,从而重建受者的胰岛素分泌功能,使其脱离使用胰岛素的一种治疗方法。
胰岛移植封装材料:指可用于胰岛封装的天然高分子或合成高分子等生物材料,具有在胰岛表面营造免疫隔离的微环境、促进移植后局部血管的生成和增加移植后的黏附性等功能。
背景:近年研究表明,用天然或合成材料将胰岛移植物封装起来在移植物表面形成一个具有免疫隔离功能的屏障,不仅能在一定程度上减少免疫抑制剂的全身使用,而且能让异种来源的胰岛成为临床移植供源。
目的:介绍胰岛移植封装材料的研究进展,描述几种胰岛封装模型,并讨论当前的研究重点和未来的发展趋势。
方法:由第一作者以“islet encapsulation,islet transplantation biomaterials,islet transplantation hydrogel”为关键词,检索PubMed、Web of Science数据库中相关文献。初检测文章447篇,筛选后纳入89篇。
结果与结论:用水凝胶包裹胰岛进行胰岛移植主要有2方面不足:一是受体免疫排斥反应的攻击,二是内部氧供和营养运输的不足。单独使用合成或天然生物材料封装胰岛并不能很好地解决这2个问题,所以必须对生物材料进行修饰。目前的胰岛水凝胶模型都倾向于将合成生物材料和天然生物材料联合起来,充分发挥它们的优势。除此之外,一些免疫调节药物、促血管生成因子或促胰岛生长相关因子等也可以加入到生物材料中,并且可以联合其他细胞共移植。如何巧妙地运用多种策略来解决上述问题是未来研究的关键。
中图分类号:
柏 雪, 王 彬, 何斯荣. 胰岛移植物封装水凝胶材料研究的重点和应用优势[J]. 中国组织工程研究, 2021, 25(10): 1585-1591.
Bai Xue, Wang Bin, He Sirong. Research focus and application advantages in encapsulating biomaterial for islet transplantation[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(10): 1585-1591.
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文题释义:#br# 胰岛移植:是指将从供者胰腺中分离出来的胰岛移植到受者体内,从而重建受者的胰岛素分泌功能,使其脱离使用胰岛素的一种治疗方法。#br# 胰岛移植封装材料:指可用于胰岛封装的天然高分子或合成高分子等生物材料,具有在胰岛表面营造免疫隔离的微环境、促进移植后局部血管的生成和增加移植后的黏附性等功能。
文章概述了近年来有关封装胰岛移植物的材料和封装策略的相关研究进展,列举了常用的几种胰岛移植物封装模型,对其封装的优缺点进行了总结,并对胰岛移植物的封装水凝胶的发展进行了展望,这些内容还未见其他文献有报道。还提出了有利于解决胰岛封装目前存在的问题的解决新策略,帮助读者在设计胰岛移植物封装水凝胶时,能够运用这些策略进行更好的构思。#br#
中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程#br#
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