中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (19): 3031-3038.doi: 10.3969/j.issn.2095-4344.3535

• 干细胞相关大数据分析 Stem cell-related big data analysis • 上一篇    下一篇

间充质干细胞治疗椎间盘退行性疾病：基于Web of Science数据库的文献计量及可视化分析

张  凯1，2，张晓勃1，2，施锦涛1，2，王克平3，周海宇1，2，3   

  1. 1兰州大学第二医院骨科，甘肃省兰州市  730030；2甘肃省骨与关节疾病研究重点实验室，甘肃省兰州市  730030；3兰州市西固区人民医院骨科，甘肃省兰州市  730060
  • 收稿日期:2020-07-16 修回日期:2020-07-21 接受日期:2020-08-29 出版日期:2021-07-09 发布日期:2021-01-13
  • 通讯作者: 周海宇，博士，主任医师，硕士生导师，兰州大学第二医院骨科，甘肃省兰州市 730030
  • 作者简介:张凯，男，陕西省西安市人，汉族，兰州大学在读硕士，主要从事脊柱退行性疾病方面的研究。
  • 基金资助:
    兰州市和西固区科技支撑计划项目(2018-3-79)，项目负责人：周海宇

Mesenchymal stem cells for treatment of intervertebral disc degeneration: a bibliometric and visualization analysis based on Web of Science database

Zhang Kai1, 2, Zhang Xiaobo1, 2, Shi Jintao1, 2, Wang Keping3, Zhou Haiyu1, 2, 3   

  1. 1Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China; 2Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou 730030, Gansu Province, China; 3Department of Orthopedics, Xigu Hospital of Lanzhou University Second Hospital, Lanzhou 730060, Gansu Province, China
  • Received:2020-07-16 Revised:2020-07-21 Accepted:2020-08-29 Online:2021-07-09 Published:2021-01-13
  • Contact: Zhou Haiyu, MD, Chief physician, Master’s supervisor, Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou 730030, Gansu Province, China; Department of Orthopedics, Xigu Hospital of Lanzhou University Second Hospital, Lanzhou 730060, Gansu Province, China
  • About author:Zhang Kai, Master candidate, Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China; Key Laboratory of Bone and Joint Disease Research of Gansu Province, Lanzhou 730030, Gansu Province, China
  • Supported by:
     Lanzhou and Xigu District Science and Technology Support Plan Project, No. 2018-3-79 (to ZHY)

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摘要：

文题释义：
Citespace软件：是基于Java开发的一款文献计量和可视化分析软件，通过对领域内研究文献的作者、摘要、关键词等进行共引分析和寻径网络算法，形成可视化的网络知识图谱和动态变化，用以探索文献正文中的关键路径，并确定特定主题知识的演变过程、分析研究热点和发展趋势。
椎间盘退行性疾病：是脊柱外科常见病，主要病因包括创伤、退变、突出等，其特征是一个或多个椎间盘破裂(退化)，从而导致腰背部疼痛，并常放射至腿和手臂。该病多见于中青年人群且有年轻化趋势，严重影响人们的身体健康和生活质量。

背景：间充质干细胞具有自我更新和多向分化的特性，在治疗椎间盘疾病中具有巨大的潜力和应用前景。
目的：针对间充质干细胞治疗椎间盘退行性疾病相关文献进行文献计量学分析，了解该领域的研究热点、发展趋势，为其后续发展提供依据和建议。
方法：以间充质干细胞治疗椎间盘退行性疾病为主题，检索2000至2019年Web of Science核心合集收录的相关文献，统计文献的年发文量、科研基金资助情况，并采用Citespace 5.5.R2软件分析作者、国家和机构的合作关系、期刊或文献的共被引情况，最后对关键词进行聚类分析、突现分析及时区图分析，并绘制出可视化的知识图谱。
结果与结论：①共纳入648篇文献，文献类型以期刊论文为主要形式；②科研基金以中国和美国资助项目最多(占基金总数的50%以上)；③共纳入作者206位，发文量≥3篇的有70位，主要研究者有Daisuke Sakai(日本)关注间充质干细胞移植治疗椎间盘退变、Judith A Hoyland(英国)关注间充质干细胞对髓核细胞表型的调节、Makarand V Risbud(美国)关注诱导间充质干细胞向髓核细胞分化；④共纳入国家和机构125个，主要国家为中国和美国；⑤共纳入期刊154个，《SPINE》杂志是收录文章最多的期刊；⑥关键词分析显示，该领域研究可分为3个阶段：第1阶段为2005至2012年，主要研究基因表达差异、间充质干细胞软骨分化、椎间盘细胞外基质改变；第2阶段为2012至2017年，主要研究间充质干细胞注射治疗及椎间盘微环境变化；第3阶段为2017至2019年，主要研究细胞疗法及间充质干细胞促进椎间盘再生；⑥结合热点关键词变化，文章预测未来的研究方向为提取培养间充质干细胞并诱导向髓核细胞分化、间充质干细胞旁分泌对椎间盘细胞作用及间充质干细胞结合组织工程技术促进椎间盘再生。


关键词: 干细胞, 间充质干细胞, 椎间盘, 椎间盘退行性疾病, 髓核细胞, Citespace, 文献计量学, 可视化分析

Abstract: BACKGROUND: Mesenchymal stem cells have the characteristics of self-renewal and multi-directional differentiation, and have great potential and application prospects in the treatment of intervertebral disc diseases. 
OBJECTIVE: To analyze the literature of mesenchymal stem cells in the treatment of intervertebral disc degenerative diseases using bibliometric analysis, and to understand the research trends and hotspots  in this field, and to provide basis and suggestions for its follow-up development.
METHODS:  With the theme of mesenchymal stem cell therapy for intervertebral disc degeneration, we searched the relevant literature included in the Web of Science database from 2000 to 2019, analyzed the annual number of paper published, and scientific research funding. Citespace5.5.R2 software was used to analyze the cooperation relationship of authors, countries and research institutions, the co-citation of journals or literatures. Finally, cluster analysis, burst analysis and time zone graph analysis were performed on keywords.  
RESULTS AND CONCLUSION: (1) A total of 648 papers were included, with journal articles as the main type of literature. (2) Most of the funding were sponsored by China and USA (more than 50%). (3) A total of 206 authors were included, out of whom 70 authors published more than 3 papers, and the principal researchers were Daisuke Sakai (Japan) focusing on mesenchymal stem cells transplantation for intervertebral disc degeneration, Judith A Hoyland (Great Britain) focusing on regulation of myeloid cell phenotype by mesenchymal stem cells, and Makarand V Risbud (US) focusing on induction of mesenchymal stem cell differentiation. (4) 125 countries and institutions were included: China and USA were the two main countries. (5) 154 journals were included, as SPINE was the journal with the most published articles. (6) The keyword analysis showed that the research in this field can be divided into three phases: phase 1 from 2005 to 2012, mainly investigating gene expression differences, chondrogenic differentiation of mesenchymal stem cells, and extracellular matrix changes in the intervertebral disc; phase 2 from 2012 to 2017, mainly investigating mesenchymal stem cell injection therapy and changes in the microenvironment of the intervertebral disc; phase 3 from 2017 to 2019, the main study is cell therapy and disc regeneration promoted by mesenchymal stem cells. (7) The probably research direction was to extract mesenchymal stem cells and induce their differentiation to nucleus pulposus, paracrine secretion of mesenchymal stem cells on the function of disc cells and mesenchymal stem cells combined with tissue engineering technology to promote intervertebral disc regeneration. 

Key words: stem cells, mesenchymal stem cells, intervertebral disc, intervertebral disc degeneration, nucleus pulposus cells, Citespace, bibliometrics, visualization analysis

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