中国组织工程研究 ›› 2020, Vol. 24 ›› Issue (27): 4376-4382.doi: 10.3969/j.issn.2095-4344.2776

• 骨与关节综述 bone and joint review • 上一篇    下一篇

晚期糖基化终末产物对骨组织细胞代谢的影响

刘  畅,王  娜,李玉坤,薛  鹏   

  1. 河北医科大学第三医院内分泌二科,河北省石家庄市   050001
  • 收稿日期:2020-01-14 修回日期:2020-01-17 接受日期:2020-02-26 出版日期:2020-09-28 发布日期:2020-09-10
  • 通讯作者: 薛鹏,博士,副教授,河北医科大学第三医院内分泌二科,河北省石家庄市 050001
  • 作者简介:刘畅,女,1994年生,河北省石家庄市人,汉族,河北医科大学第三医院在读硕士,主要从事糖尿病与骨代谢研究。
  • 基金资助:
    河北省高层次人才资助项目(A2017003079);京津冀基础研究合作专项(19JCZDJC65500Z);河北省医学适用技术跟踪项目(G2019008);骨质疏松和骨矿盐疾病中青年医生优才培养计划(GX20191107)

Effect of advanced glycation end products on metabolism of bone tissue cells

Liu Chang, Wang Na, Li Yukun, Xue Peng   

  1. Second Department of Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050001, Hebei Province, China
  • Received:2020-01-14 Revised:2020-01-17 Accepted:2020-02-26 Online:2020-09-28 Published:2020-09-10
  • Contact: Xue Peng, MD, Associate professor, Second Department of Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050001, Hebei Province, China
  • About author:Liu Chang, Master candidate, Second Department of Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050001, Hebei Province, China
  • Supported by:
    the High-Level Talent Support Project of Hebei Province, No. A2017003079; the Basic Research Cooperation Project of Beijing, Tianjin and Hebei Province, No. 19JCZDJC65500Z; the Medical Applicable Technology Following Project of Hebei Province, No. G2019008; the Developing Program for Young and Middle-aged Doctors with Osteoporosis and Bone Mineral Diseases, No. GX20191107

摘要:

文题释义:

晚期糖基化终末产物是还原糖(如葡萄糖)和某些代谢产物(如甲基已二醛)与蛋白质氨基经过非酶促反应生成的多种化合物,可以积聚在骨组织中,影响骨组织的结构和力学性能,导致骨强度显著下降。

骨胶原交联骨胶原分子交联包括有利的酶催化交联(即未成熟的二价交联、成熟的三价交联)和不利的非酶催化交联。在骨组织发育过程中,胶原分子在酶催化的情况下,形成不成熟的二价交联,其中一部分二价交联进一步成熟形成三价交联;而在无酶催化情况下交联反应可形成晚期糖基化终末产物。

背景:随着骨组织工程学的研究和发展,发现晚期糖基化终末产物可以在骨组织中积累,影响骨骼的结构及生物力学性能。目前许多研究发现晚期糖基化终末产物/晚期糖基化终末产物受体通过特殊的作用机制后能够引起以成骨细胞、破骨细胞及骨细胞为主的骨组织细胞发生病理改变,导致骨重建失衡,骨骼强度下降,骨折发生率增加。

目的综述晚期糖基化终末产物对骨骼生物力学的影响以及晚期糖基化终末产物/晚期糖基化终末产物受体对骨组织细胞的作用机制。

方法由第一作者检索20051月至 20197 月在PubMedWeb of Science Medline数据库发表的有关晚期糖基化终末产物/晚期糖基化终末产物受体对骨组织细胞代谢的影响的文章,检索结果限于英文文献。

结果与结论:最终选取具有代表性的54篇文献进行归纳总结。晚期糖基化终末产物对骨胶原交联的影响,使得骨强度显著下降;晚期糖基化终末产物/晚期糖基化终末产物受体通过使骨组织细胞发生病理机制改变影响骨代谢,使得骨组织细胞发生本质改变。最终导致骨代谢平衡紊乱,骨骼脆性增加。骨质疏松症的发生与骨代谢相关的细胞活力改变有着直接关系,但具体相关作用机制需进一步研究,而这种特殊机制的改变在今后有可能为骨质疏松症提供独特的病理机制、诊断思维和相关治疗及预防策略。

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程

关键词: 晚期糖基化终末产物, 晚期糖基化终末产物受体, 骨胶原分子, 交联, 骨组织细胞, 骨强度, 骨质量, 骨质疏松

Abstract:

BACKGROUND: With the research and development of bone tissue engineering, it has been found that advanced glycation end products can accumulate in bone tissue and affect the structure and biomechanical properties of bone. At present, many researchers have discovered that advanced glycation end products/receptor for advanced glycation end products can induce pathological changes of osteoblasts, osteoclasts and osteocytes through special mechanisms, thereby leading to imbalance of bone reconstruction, decrease of bone strength and increase of fracture incidence.

OBJECTIVE: To review the effects of advanced glycation end products on bone biomechanics and the mechanism of advanced glycation end products/receptor for advanced glycation end products on bone tissue cells.

METHODS: The first author searched the relevant articles regarding the effect of advanced glycation end products/receptor for advanced glycation end products on metabolism of bone tissue cells published in PubMed, Web of Science and Medline database from January 2005 to July 2019. The results were limited to English literatures.

RESULTS AND CONCLUSION: Finally, 54 representative literatures were selected for summary. The effects of advanced glycation end products on collagen cross-linking can significantly reduce bone strength. Advanced glycation end products/receptor for advanced glycation end products affects bone metabolism through pathological mechanism changes of bone tissue cells, which results in essential changes of bone tissue cells. Finally, it will lead to imbalance of bone metabolism and increase of bone fragility. The osteoporosis is directly related to the activity change of bone tissue cells, but the specific mechanism needs further study. The change of this special mechanism may provide a unique pathological mechanism, diagnosis methods, treatment and prevention strategies for osteoporosis in the future.

Key words: advanced glycation end products; receptor for advanced glycation end products; bone collagen molecule; cross-linking; bone tissue cells; bone strength; bone quality; osteoporosis

Key words: advanced glycation end products, receptor for advanced glycation end products, bone collagen molecule, cross-linking, bone tissue cells, bone strength, bone quality, osteoporosis

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