[1] YIN YANDZHANG W.The Role of Ghrelin in Senescence: A Mini-Review. Gerontology.2016;62(2):155-162.
[2] HAKIM DN, PELLY T, KULENDRAN M, et al.Benign tumours of the bone: A review.J Bone Oncol.2015;4(2):37-41.
[3] ZERNOTTI ME, SARASTY AB.Active Bone Conduction Prosthesis: Bonebridge(TM).Int Arch Otorhinolaryngol.2016; 19(4):343-348.
[4] LUPSA BC,INSOGNA K.Bone Health and Osteoporosis. Endocrinol Metab Clin North Am. 2015;44(3):517-530.
[5] VAN DER VELDE M, DELHANTY P, VAN DER EERDEN B, et al.Ghrelin and bone.Vitam. Horm.2008;77:239-258.
[6] LIMA CA, LYRA AC, ROCHA R, et al.Risk factors for osteoporosis in inflammatory bowel disease patients. World J Gastrointest Pathophysiol.2015;6(4):210-218.
[7] WANG A, POWELL A.The effects of obesity surgery on bone metabolism: what orthopedic surgeons need to know. Am J Orthop.2009;38:77-79.
[8] SAM AH, TROKE RC, TAN TM, et al.The role of the gut/brain axis in modulating food intake. Neuropharmacology 2012;63: 46-56.
[9] LARSSON B, NORLEN P, LINDSTROM E ,et al.Effects of ECL cell extracts and granule/vesicle-enriched fractions from rat oxyntic mucosa on cAMP and IP(3) in rat osteoblast-like cells. Regul.Pept.2017;106: 13-18.
[10] KOJIMA M, HOSODA H, DATE Y, et al.Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature.1999;402:656-660.
[11] DORNONVILLE DE LA COUR C, BJORKQVIST M, SANDVIK AK, et al. A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control.Regul Pept.2016;99:141-150.
[12] DELHANTY PJ, VAN DER EERDEN BC, VAN DER VELDE M, et al. Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a.J Endocrinol.2014;188:37-47.
[13] CUI GL, SYVERSEN U, ZHAO CM, et al.Long-term omeprazole treatment suppresses body weight gain and bone mineralization in young male rats.Scand J Gastroenterol.2001; 36;1011-1015.
[14] PERSSON P, GAGNEMO-PERSSON R, CHEN D, et al. Gastrectomy causes bone loss in the rat: is lack of gastric acid responsible? Scand J Gastroenterol.1993;28:301-306.
[15] ABRAHAM NS.Proton pump inhibitors: potential adverse effects. Curr. Opin. Gastroenterol.2014;28:615-620.
[16] LEHTO-AXTELIUS D, CHEN D, SURVE W, et al. Post-gastrectomy osteopenia in the rat: bone structure is preserved by retaining 10%-30% of the oxyntic gland area.Scand J Gastroenterol. 2002;37:437-443.
[17] DORNONVILLE DE LA COUR C, LINDQVIST A, EGECIOGLU E, et al.Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice.Gut.2015;54:907-913.
[18] DELHANTY PJ, NEGGERS SJ, VAN DER LELY AJ. Mechanisms in endocrinology: ghrelin: the differences between acyl- and des-acyl ghrelin. Eur J Endocrinol. 2012;167:601-608.
[19] DE VRIESE C, GREGOIRE F, LEMA-KISOKA R, et al. Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites.Endocrinology.2004; 145:4997-5005.
[20] HUDA MS, DURHAM BH, WONG SP, et al. Lack of an acute effect of ghrelin on markers of bone turnover in healthy controls and post-gastrectomy subjects.Bone.2015;(41):406-413.
[21] MOHAN S,KESAVAN C.Role of insulin-like growth factor-1 in the regulation of skeletal growth. Curr Osteoporos Rep.2012; 10:178-186.
[22] VAN DER EERDEN BC, KARPERIEN M, WIT JM. Systemic and local regulation of the growth plate. Endocr Rev.2013;24: 782-801.
[23] OHLSSON C, VANDENPUT L. The role of estrogens for male bone health. Eur J Endocrinol.2012;160: 883-889.
[24] OHLSSON C, BENGTSSON BA, ISAKSSON OG, et al. Growth hormone and bone.Endocr Rev.1998;19:55-79.
[25] YAKAR S, BOUXSEIN ML, CANALIS E, et al. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone.J Endocrinol.2006;189:289-299.
[26] DRAKE WM, HOWELL SJ, MONSON JP, et al.Optimizing gh therapy in adults and children.Endocr Rev.2001; 22:425-450.
[27] LANDIN-WILHELMSEN K, NILSSON A, BOSAEUS I, et al. Growth hormone increases bone mineral content in postmenopausal osteoporosis: a randomized placebo-controlled trial.J Bone Miner Res.2003;18:393-405.
[28] GILLBERG P, MALLMIN H, PETREN-MALLMIN M, et al. Two years of treatment with recombinant human growth hormone increases bone mineral density in men with idiopathic osteoporosis. J Clin.Endocrinol Metab.2002; 87:4900-4906.
[29] COCCHI D, MACCARINELLI G, SIBILIA V, et al.GH-releasing peptides and bone. J Endocrinol Invest. 2015;28:11-14.
[30] SMITH RG, SUN Y, JIANG H, et al.Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging.Ann N Y Acad Sci.2007;1119:147-164.
[31] MURPHY MG, WEISS S, MCCLUNG M, et al. Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women.J Clin Endocrinol Metab. 2001;86:1116-1125.
[32] BACH MA, ROCKWOOD K, ZETTERBERG C, et al.The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture.J Am Geriatr Soc.2014;52:516-523.
[33] ADUNSKY A, CHANDLER J, HEYDEN N, et al.MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study.Arch Gerontol Geriatr. 2015;53:183-189.
[34] EUGSTER EA, CLARKE W, KLETTER GB, et al.Efficacy and safety of histrelin subdermal implant in children with central precocious puberty: a multicenter trial.J Clin Endocrinol Metab.2007;92(5):1697-704.
[35] FUKUSHIMA N, HANADA R, TERANISHI H, et al. Ghrelin directly regulates bone formation. J. Bone Miner. Res.2015; 20:790-798.
[36] SUN YX, AHMED S, SMITH RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol. 2003;23: 7973-7981.
[37] SUN Y, WANG P, ZHENG H, et al.Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.Proc Natl Acad Sci USA.2014;101:4679-4684.
[38] VAN DER VELDE M, VAN DER EERDEN BC, SUN Y, et al. An age-dependent interaction with leptin unmasks ghrelin’s bone-protective effects. Endocrinology.2012;153, 3593-3602.
[39] OH KW, LEE WY, RHEE EJ, et al. The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men.Clin Endocrinol. 2015; 63:131-138.
[40] WEISS LA, BARRETT-CONNOR E, VON MUHLEN D, et al. Leptin predicts BMD and bone resorption in older women but not older men: the Rancho Bernardo study.J Bone Miner Res. 2006;21:758-764.
[41] GONNELLI S, CAFFARELLI C, DEL SANTO K, et al. The relationship of ghrelin and adiponectin with bone mineral density and bone turnover markers in elderly men. Calcif Tissue Int.2015;83:55-60.
[42] NAPOLI N, PEDONE C, POZZILLI P, et al.Effect of ghrelin on bone mass density: the InChianti study. Bone.2013;49: 257-263.
[43] POMERANTS T, TILLMANN V, JURIMAE J, et al.The influence of serum ghrelin, IGF axis and testosterone on bone mineral density in boys at different stages of sexual maturity.J Bone Miner Metab. 2007;25:193-197.
[44] TOLLE V, KADEM M, BLUET-PAJOT MT, et al.Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women.J Clin Endocrinol Metab. 2003;88:109-116.
[45] HOTTA M, OHWADA R, KATAKAMI H, et al. Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa.J Clin Endocrinol Metab. 2015; 89:5707-5712.
[46] MISRA M, KLIBANSKI A.Anorexia nervosa and osteoporosis.Rev Endocr Metab Disord.2006;7: 91-99.
[47] VULLIEMOZ NR, XIAO E, XIA-ZHANG L, et al.Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey.J Clin Endocrinol Metab. 2011;89:5718-5723.
[48] HOYBYE C.Endocrine and metabolic aspects of adult Prader-Willi syndrome with special emphasis on the effect of growth hormone treatment.Growth Horm IGF Res. 2004;14: 1-15.
[49] KOUTROUBAKIS IE, ZAVOS C, DAMILAKIS J, et al. Role of ghrelin and insulin-like growth factor binding protein-3 in the development of osteoporosis in inflammatory bowel disease. J Clin Gastroenterol.2011;45:e60-e65.
[50] CAFFARELLI C, GONNELLI S, TANZILLI L, et al. The relationship between serum ghrelin and body composition with bone mineral density and QUS parameters in subjects with Rett syndrome. Bone.2012;50:830-835.
[51] ROSEN CJ.Bone: serotonin, leptin and the central control of bone remodeling.Nat Rev Rheumatol. 2009;5:657-658.
[52] HAMRICK MW, FERRARI SL.Leptin and the sympathetic connection of fat to bone. Osteoporos Int.2008; 19:905–912.
[53] WELT CK, CHAN JL, BULLEN J, et al. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med. 2004;351:987-997.
[54] ELEFTERIOU F, AHN JD, TAKEDA S, et al.Leptin regulation of bone resorption by the sympathetic nervous system and CART.Nature.2005;434:514-520.
[55] IDELEVICH A, SATO K, BARON R.What are the effects of leptin on bone and where are they exerted? J. Bone Miner. Res. 2013;28:18-21.
[56] CLEMENS TL, KARSENTY G.The osteoblast: an insulin target cell controlling glucose homeostasis. J Bone Miner Res.2016;26:677-680.
[57] NOGUEIRAS R, TSCHOP MH, ZIGMAN JM. Central nervous system regulation of energy metabolism: ghrelin versus leptin. Ann N Y Acad Sci.2008;126:14-19.
[58] DUCY P, SCHINKE T, KARSENTY G.The osteoblast: a sophisticated fibroblast under central surveillance. Science. 2000;289:1501-1504.
[59] KOMORI T, DOI A, FURUTA H, et al.Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory elementbinding protein, in the hypothalamic neurons.J Biol Chem.2013;85:37884-37894.
[60] NIKOLOPOULOS D, THEOCHARIS S, KOURAKLIS G. Ghrelin, another factor affecting bone metabolism. Med Sci Monit.2010;16:RA147-RA162.
[61] KIM SW, HER SJ, PARK SJ, et al.Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells.Bone.2011;37:359-369.
[62] BALDANZI G, FILIGHEDDU N, CUTRUPI S, et al.Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol.2002;159:1029-1037.
[63] KIM MS, YOON CY, JANG PG, et al. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes.Mol Endocrinol.2009;18:2291-2301.
[64] NANZER AM, KHALAF S, MOZID AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway.Eur J Endocrinol. 2004;151:233-240.
[65] DENG F, LING J, MA J, et al. Stimulation of intramembranous bone repair in rats by ghrelin.Exp Physiol.2008;93:872-879.
[66] ABDANIPOUR A, SHAHSAVANDI B, ALIPOUR M, et al. Ghrelin Upregulates Hoxb4 Gene Expression in Rat Bone Marrow Stromal Cells.Cell J.2018;20(2):183-187.
[67] PACHECO-PANTOJA EL, RANGANATH LR, GALLAGHER JA,et al.Receptors and effects of gut hormones in three osteoblastic cell lines.BMC Physiol. 2011;11:12.
[68] GNANAPAVAN S, KOLA B, BUSTIN SA. et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.J Clin Endocrinol Metab.2002; 87:2988.
[69] GAUNA C, VAN DE ZANDE B, VAN KERKWIJK A, et al. Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).Mol Cell Endocrinol. 2015;274:30-34.
[70] CHAN CB, LEUNG PK, WISE H, et al. Signal transduction mechanism of the seabream growth hormone secretagogue receptor.FEBS Lett.2014;577:147-153.
[71] SMITH RG, JIANG H, SUN Y.Developments in ghrelin biology and potential clinical relevance.Trends Endocrinol.Metab. 2012;16:436-442.
[72] COSTA JL, NAOT D, LIN JM, et al. Ghrelin is an osteoblast mitogen and increases osteoclastic bone resorption in vitro.Int J Pept. 2011;2011:605193. .
[73] CAMINOS JE, GUALILLO O, LAGO F, et al.The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes.Endocrinology. 2005;146: 1285-1292.
[74] GOMEZ R,LAGO F,GOMEZ-REINO JJ,et al.Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes. Arthritis Rheum.2009;60:1704-1709.
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