中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (50): 7594-7600.doi: 10.3969/j.issn.2095-4344.2016.50.021

• 干细胞综述 stem cell review • 上一篇    

淫羊藿苷促进间充质干细胞成骨分化：为治疗骨缺损提供一个良好的方向

陈震东1，高  辉2，徐房添2   

  1. 1赣南医学院，江西省赣州市  341000
    2赣南医学院第一临床医学院，江西省赣州市  341000
  • 修回日期:2016-09-07 出版日期:2016-12-02 发布日期:2016-12-02
  • 通讯作者: 徐房添，博士，副主任医师，副教授，赣南医学院第一临床医学院，江西省赣州市 341000
  • 作者简介:陈震东，男，1989年生，江西省赣州市人，汉族，赣南医学院2014级临床医学在读硕士，医师，主要从事脂肪间充质干细胞和组织工程方面的研究。
  • 基金资助:

    国家自然科学基金(8156090191)

Icariin promotes the osteogenic differentiation of mesenchymal stem cells: a good candidate for bone defect repair

Chen Zhen-dong1, Gao Hui2, Xu Fang-tian2   

  1. 1Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
    2First Clinical College of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
  • Revised:2016-09-07 Online:2016-12-02 Published:2016-12-02
  • Contact: Xu Fang-tian, M.D., Associate chief physician, Associate professor, First Clinical College of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
  • About author:Chen Zhen-dong, Studying for master’s degree, Physician, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 8156090191

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摘要：

文章快速阅读：

文题释义：
淫羊藿：是中国传统中草药，为小檗科淫羊藿属植物。淫羊藿苷是淫羊藿的主要成分，其主要由黄酮类化合物、木脂素及生物碱组成。传统中医认为淫羊藿苷具有强筋健骨，补肾助阳的作用。近年来研究表明淫羊藿苷可作为骨性营养因子，在体内和体外实验证实能够促进间质干细胞成骨分化，是一种良好的骨性诱导因子，对骨缺损的治疗提供了新的希望。
骨形态发生蛋白：与胚胎骨骼形成有关的蛋白质，在骨形成的数个阶段均起作用，由形态发生的早期阶段开始，并延续至出生后。在中枢神经的发生中也起着关键作用。

 

摘要
背景：近年来研究表明，淫羊藿苷能够促进间充质干细胞成骨分化，是一种良好的骨性诱导因子，给骨缺损的治疗提供了新的希望。
目的：综述近年来淫羊藿苷对骨组织代谢的药理作用及对间充质干细胞成骨分化影响的研究成果。
方法：由第一作者用中国知网数据库和PubMed数据库，检索词分别为“淫羊藿苷；干细胞；成骨”和“icariin，stem cell，osteogenesis”，语言分别设定为中文和英文。纳入与“淫羊藿苷、干细胞、成骨”相关的研究。共检索到754篇文章，按纳入和排除标准文献进行筛选，共纳入41篇文章进行综述分析。
结果与结论：淫羊藿苷是中国传统中药淫羊藿的主要成分，能够促进骨髓间充质干细胞成骨分化，是一种良好的骨性营养因子。近年来研究表明，淫羊藿苷亦可促进脂肪、脐带以及牙周膜等组织来源的间充质干细胞成骨分化，但是这类研究尚少。目前各间充质干细胞成骨实验效果欠佳，良好的骨性营养因子促进间充质干细胞体内成骨是一种较好的解决方法。因此，淫羊藿苷促进间充质干细胞成骨将可能为治疗骨缺损提供一个良好的方向。

 

 

关键词: 干细胞, 分化, 淫羊藿苷, 药理作用, 骨缺损, 骨髓间充质干细胞, 脂肪间充质干细胞, 脐带间充质干细胞, 牙周膜干细胞, 成骨分化, 分子机制, 国家自然科学基金

Abstract:

BACKGROUND: Recent studies have shown that icariin is a good bone-inducing factor that can promote the osteogenic differentiation of mesenchymal stem cells, providing a new hope for the treatment of bone defects.
OBJECTIVE: To review research achievements in pharmacological effects of icariin effects on bone tissue metabolism as well as its effect to promote osteogenic differentiation of mesenchymal stem cells.
METHODS: The first author retrieved CNKI and PubMed databases for relevant Chinese and English literatures using keywords of “icariin, stem cell, osteogenesis”, respectively. Articles regarding icariin, stem cells, osteogenesis were included, and repetitive studies were excluded. Totally 754 articles were retrieved initially. In accordance with inclusion and exclusion criteria, 41 articles were included in result analysis.
RESULTS AND CONCLUSION: As the main ingredient of Herba epimedii, icariin functions as a good osteogenetic growth factor to promote the osteogenic differentiation of bone marrow mesenchymal stem cells. In recent years, icariin has been shown to promote adipose-, umbilical cord-, and periodontal ligament tissue-derived mesenchymal stem cells to differentiate into osteoblasts. But such studies are less reported. Until now, mesenchymal stem cells still exhibit unsatisfactory osteogenic ability in in vivo experiments. Given this, osteogenetic growth factors contribute to the osteogenic differentiation of mesenchymal stem cells. Therefore, the use of icariin is expected to provide a good strategy for bone defect repair.

 

 

Key words: Stem Cells, Tissue Engineering, Bone Marrow

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