中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (12): 1938-1942.doi: 10.3969/j.issn.2095-4344.2015.12.025

• 生物材料综述 biomaterial review • 上一篇    下一篇

组织工程骨修复骨缺损的稳定性：材料降解与新骨形成

周  骁，钱玉芬   

  1. 上海交通大学医学院附属第九人民医院口腔正畸科，上海市口腔医学重点实验室，上海市  200011
  • 修回日期:2015-01-29 出版日期:2015-03-19 发布日期:2015-03-19
  • 通讯作者: 钱玉芬，主任医师/教授，上海交通大学医学院附属第九人民医院口腔正畸科，上海市口腔医学重点实验室，上海市 200011
  • 作者简介:周骁，男，1991年生，上海市人，汉族，上海交通大学医学院在读硕士，主要从事口腔正畸学研究。
  • 基金资助:

    国家自然科学基金资助项目(81170989)：正畸扩弓促进牙槽突裂组织工程骨修复稳定性及邻牙移入的可行性研究

Stability of tissue engineering bone in the repair of bone defects: material degradation and bone formation

Zhou Xiao, Qian Yu-fen   

  1. Shanghai Key Laboratory of Stomatology, Department of Orthodontics, the Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
  • Revised:2015-01-29 Online:2015-03-19 Published:2015-03-19
  • Contact: Qian Yu-fen, Chief physician, Professor, Shanghai Key Laboratory of Stomatology, Department of Orthodontics, the Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
  • About author:Zhou Xiao, Studying for master’s degree, Shanghai Key Laboratory of Stomatology, Department of Orthodontics, the Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81170989

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摘要：

背景：支架材料是组织工程骨重要的组成部分，理想材料的生物降解速度应与新骨替代生成速度一致，最终材料完全降解被新骨取代，以达到长期稳定的目的。
目的：综述现有不同类型支架材料的降解及其与新骨形成的关系。
方法：由第一作者从PubMed数据库及CNKI数据库中，以“tissue engineering bone，composite scaffold，scaffold degradation；组织工程骨，支架材料，生物降解”为主题词检索1996年1月至2013年12月间发表的文献，选择与支架材料降解及其与新骨形成关系的相关文献。
结果与结论：目前已有多种有机、无机及有机-无机复合材料作为支架材料，近年来重点是对无机材料及有机-无机材料复合物开展研究。体内外实验结果表明，各类材料具备不同的特性且各有优劣。有机材料降解速率相对较慢，无机材料虽能完全降解，但机械性能不够，对于复合材料仍需要开展进一步的动物实验和临床研究。


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

关键词: 生物材料, 骨生物材料, 组织工程骨, 支架材料, 生物降解, 植骨稳定性, 国家自然科学基金

Abstract:

BACKGROUND: Scaffold materials are the important part of tissue engineering bone, and the ideal biodegradation speed of the scaffold materials can be in accordance with the regeneration speed of bone formation in order to achieve a long-term stability.
OBJECTIVE: To summarize the biodegradability of different types of currently available scaffold materials and its relationship with bone formation.
METHODS: The PubMed and CNKI database were searched by the first author using the key words of “tissue engineering bone, composite scaffold, scaffold degradation” in English and Chinese for articles addressing biodegradability of scaffold materials and its relationship with bone formation published during January 1996 and December 2013.
RESULTS AND CONCLUSION: Many scaffold materials under organic, inorganic and organic-inorganic categories have been available and the current studies focus on inorganic materials and organic-inorganic composite materials. In vivo and in vitro studies indicate the different characteristics and relative merits of these scaffold materials. Organic materials have a relatively slow degradation rate while inorganic materials can completely degrade but have an insufficient mechanical property. For organic-inorganic composite materials, further studies are needed.


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

Key words: Tissue Engineering, Stents, Bone Transplantation

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